Opioid analgesics and narcotic antagonists

Tabernaemontana catharinensis ethyl acetate fraction presents antinociceptive activity without causing toxicological effects in mice

“…Similarly, Gomes et al (2009) demonstrated antinociceptive effects for Eta from the T. catharinensis stem bark in a thermal model of nociception. As expected, morphine was able to produce antinociception in the tailimmersion test, proving its action as a central analgesic (Aronson, 2014). Eta exerted a significant protective effect on chemical (acetic acid injection) but not thermal (tailimmersion) painful stimuli.…”