Opioid Education and Nasal Naloxone Rescue Kits in the Emergency Department

Dwyer, Kristin H.; Walley, Alex; Langlois, Breanne K.; Mitchell, Patricia; Nelson, Kerrie P.; Cromwell, John W.; Bernstein, Edward

doi:10.5811/westjem.2015.2.24909

Cited by 128 publications

(110 citation statements)

References 8 publications

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“…Since the early 2000s, nasal naloxone has been used off-label by ambulance personnel (Barton et al, 2005(Barton et al, , 2002Belz et al, 2006;Kelly et al, 2005;Kerr et al, 2009;Merlin et al, 2010;Robertson et al, 2009;Weber et al, 2012) and in the emergency department (Sabzghabaee et al, 2014). More recently, improvised nasal kits (consisting of a prefilled naloxone syringe and an atomizer which fits onto the syringe to generate a nasal spray) have been provided to opioid users, peers, and families in take-home naloxone trials (Doe-Simkins et al, 2009;Dwyer et al, 2015;Walley et al, 2013aWalley et al, , 2013b, and succesful overdose reversals using improvised nasal kits have also been reported for police first responders (Rando et al, 2015). However, the only published pharmacokinetics study in humans found intranasal naloxone (2mg/5ml) had a relative bioavailability of only 4% (Dowling et al, 2008).…”

Section: Sublingualmentioning

confidence: 99%

Naloxone without the needle − systematic review of candidate routes for non-injectable naloxone for opioid overdose reversal

Strang

McDonald

Alqurshi

et al. 2016

Drug and Alcohol Dependence

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. (2016). Naloxone without the needle systematic review of candidate routes for non-injectable naloxone for opioid overdose reversal. Drug and Alcohol Dependence. DOI: 10.1016DOI: 10. /j.drugalcdep.2016 Citing this paper Please note that where the full-text provided on King's Research Portal is the Author Accepted Manuscript or Post-Print version this may differ from the final Published version. If citing, it is advised that you check and use the publisher's definitive version for pagination, volume/issue, and date of publication details. And where the final published version is provided on the Research Portal, if citing you are again advised to check the publisher's website for any subsequent corrections. General rightsCopyright and moral rights for the publications made accessible in the Research Portal are retained by the authors and/or other copyright owners and it is a condition of accessing publications that users recognize and abide by the legal requirements associated with these rights.•Users may download and print one copy of any publication from the Research Portal for the purpose of private study or research.•You may not further distribute the material or use it for any profit-making activity or commercial gain •You may freely distribute the URL identifying the publication in the Research Portal Take down policy If you believe that this document breaches copyright please contact librarypure@kcl.ac.uk providing details, and we will remove access to the work immediately and investigate your claim. This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. After 40 years of injection-based naloxone treatment, non-injectable routes are finally being developed. Nasal naloxone has recently been approved and will soon be fieldtested, buccal naloxone holds promise, and it is unclear what sublingual naloxone will contribute. Development and approval of reliable non-injectable formulations will facilitate wider naloxone provision across the community internationally.

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Section: Sublingualmentioning

confidence: 99%

Naloxone without the needle − systematic review of candidate routes for non-injectable naloxone for opioid overdose reversal

Strang

McDonald

Alqurshi

et al. 2016

Drug and Alcohol Dependence

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“…57 Ten strategies had a negligible or no impact on overdoses and deaths. 35,41,49,52,68,70,75,76,81,93 Five strategies had a small positive effect, 48,50,53,62,94 two had a moderate positive effect, 55,56 and four had a large positive effect, 60,63,69,82 which included (1) overdose prevention training and naloxone distribution, plus a change in the legal status of naloxone to permit its administration by any member of the public Most promising strategies by content and target audience Figure 5a and 5b show the impact of the strategies by content and target population. It suggests that the most promising strategies to improve appropriate use of opioids are (1) educational strategies aimed at health care professionals; (2) clinical strategies aimed at patients, opioid users, and health care professionals; and (3) collaborations.…”

Section: Impact On Overdose and Deathsmentioning

confidence: 99%

A systematic review of strategies to improve appropriate use of opioids and to reduce opioid use disorder and deaths from prescription opioids

Furlan

Carnide

Irvin

et al. 2018

Canadian Journal of Pain

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Background: Abuse of prescription opioids is a serious problem in North America. Aims: The aim of this study was to conduct a systematic review of peer-reviewed and grey literature to examine existing strategies aimed at improving the appropriate use of prescription opioids and/or reducing the misuse, abuse, and diversion of these drugs. Methods: The following electronic databases were searched to September 2015 without language restrictions: MEDLINE, EMBASE, PsycINFO, and CINAHL; the grey literature was searched to May 2014. Reference lists of retrieved papers were also searched. Studies were eligible if a strategy was implemented and its impact on at least one of the primary outcomes of interest (appropriate prescription opioid use; misuse, abuse, opioid use disorder, diversion; overdose) was measured. Standardized, prepiloted forms were used for relevance screening, quality appraisal, and data extraction. Results: A total of 65 studies that assessed 66 distinct strategies were identified. Due to the heterogeneity of the strategies, a qualitative synthesis was conducted. Many studies combined more than one type of strategy and measured various types of outcomes. The strategies with most promising results involved education, clinical practices, collaborations, prescription monitoring programs, public campaigns, opioid substitution programs, and naloxone distribution. We also found strategies that had some unintended consequences after implementation. Conclusions: Our review identified successful strategies that have been implemented and evaluated in various jurisdictions. There is a need to replicate and disseminate these strategies where the problem of prescription opioid misuse and abuse has taken a toll on society.

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“…Public emergency occur and therefore, how to safely admit to hurt the wounded, orderly, efficient has always been an important task to all levels of hospital. Nursing is an important part of hospital emergency treatment work, must establish perfect and scientific system of emergency treatment that can improve the ability of nurses of the emergency rescue which is important [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

Research on the Interactive Training Pattern and the Applications on the Modern Emergency Rescue Training Activities

Hua¹,

He²,

Zhang³

et al. 2016

Proceedings of the 2016 2nd International Conference on Social Science and Technology Education (ICSSTE 2016)

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Abstract-In this paper, we conduct research on the interactive training pattern and the applications on the modern emergency rescue training activities. In emergency rescue training linkage the ecological communities, important is not gathered themselves together, and not the size of the momentum and the strength that is not the amount of emergency rescue training linkage performance, important is the ecological communities each organic elements in the function of the cohesion, lies in the relationship between the organic elements in ecological communities, the construction and the development is the specific ecological communities in action elements of emergency rescue training, joint quality lies in the emergency rescue training. These contents are involved in the emergency rescue training linkage management model of concrete. Under this basis, we integrate the condition of the Hainan Medical School to propose the corresponding suggestions that will enhance the performance.

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Opioid Education and Nasal Naloxone Rescue Kits in the Emergency Department

Cited by 128 publications

References 8 publications

Naloxone without the needle − systematic review of candidate routes for non-injectable naloxone for opioid overdose reversal

Naloxone without the needle − systematic review of candidate routes for non-injectable naloxone for opioid overdose reversal

A systematic review of strategies to improve appropriate use of opioids and to reduce opioid use disorder and deaths from prescription opioids

Research on the Interactive Training Pattern and the Applications on the Modern Emergency Rescue Training Activities

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