IntroductionNational guidelines recommend against initiating concurrent opioids and benzodiazepines due to opioid overdose risk; however, limited evidence exists evaluating implementation strategies. The San Francisco Veterans Affairs Health Care System implemented an electronic clinical pharmacy specialist consult to evaluate new combination opioid and benzodiazepine requests. Reviewing pharmacists often recommend alternative therapies and safety strategies.ObjectivesThe primary objective of this study evaluated the outcome of consults placed (approved, short‐term approved, not approved, discontinued). Secondarily, types of recommendations made and implementation results after 1 month (implemented by prescriber, offered but patient declined, or not implemented) were evaluated.MethodsA retrospective electronic medical record review was completed for all consults requesting new combination opioids and benzodiazepines from February 19, 2016 to June 25, 2019. Descriptive statistics evaluated the consult request, treatment indication, and consult outcome. Linear regression evaluated the relationship between recommendations and number implemented.ResultsA total of 121 consults were placed and not approved (41%), discontinued (31%), short‐term approved (23%), or approved (5%). A total of 95 consults (79%) had ≥1 recommendation, and the most common were non‐benzodiazepine medication alternatives (42%), patient education (37%), and behavioral therapy (34%). Among those, 51% had ≥1 recommendation implemented, and the most common were patient education (36%), non‐benzodiazepine medication alternatives (29%), and specialty team referral (32%). Number of recommendations significantly predicted the number implemented by providers (P < .001).ConclusionImplementation of an electronic opioid and benzodiazepine new start consult evaluated by clinical pharmacy specialists resulted in a low rate of approval, reducing use of this risky combination. Among consults with ≥1 recommendation made, the implementation rate was high at >50%. Providing a variety of ≥5 recommendations increased the likelihood of implementation. Future research should examine the impact on reducing opioid‐related adverse events and engaging in recommended treatment alternatives.