Opioid use during pregnancy can impair maternal behavior and the Maternal Brain Network: A literature review

Wallin, Chela M.; Bowen, Scott E.; Brummelte, Susanne

doi:10.1016/j.ntt.2021.106976

Cited by 15 publications

(15 citation statements)

References 209 publications

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“…The third subsystem generates appetitive states and desire to care for a newborn. This includes the mPOA, NAc, and VTA [ 44 ], but some areas, such as the medial amygdala, seem to participate in all three functions [ 45 ]. Thus, cross fostering can successfully occur when the first subsystem is not highly selective to the own offspring.…”

Section: The Seven Basic Neurobiological Systems Of Behaviormentioning

confidence: 99%

The Neurobiology of Behavior and Its Applicability for Animal Welfare: A Review

Coria-Ávila

Pfaus

Orihuela

et al. 2022

Animals

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Understanding the foundations of the neurobiology of behavior and well-being can help us better achieve animal welfare. Behavior is the expression of several physiological, endocrine, motor and emotional responses that are coordinated by the central nervous system from the processing of internal and external stimuli. In mammals, seven basic emotional systems have been described that when activated by the right stimuli evoke positive or negative innate responses that evolved to facilitate biological fitness. This review describes the process of how those neurobiological systems can directly influence animal welfare. We also describe examples of the interaction between primary (innate) and secondary (learned) processes that influence behavior.

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Section: The Seven Basic Neurobiological Systems Of Behaviormentioning

confidence: 99%

The Neurobiology of Behavior and Its Applicability for Animal Welfare: A Review

Coria-Ávila

Pfaus

Orihuela

et al. 2022

Animals

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“…As addiction dysregulates the neural circuitry implicated in reward processing, it decreases the salience or perceived value of nondrug rewards (Garavan et al, 2000;Volkow et al, 2010). During the perinatal period, these neurobiological changes may interfere with the neurocircuitry responsible for maternal bonding behaviors (Wallin et al, 2021). Prolonged drug use also affects stress circuitry, activating the HPA axis to release molecular mediators of antireward (Koob and Le Moal, 2008), including cortisol, corticotropin-releasing factor, and adrenocorticotropin hormone, producing aversive states during withdrawal or extended abstinence.…”

Section: Problem-focused and Emotion-focused Copingmentioning

confidence: 99%

An Integrated Mechanistic Model of Mindfulness-Oriented Recovery Enhancement for Opioid-Exposed Mother–Infant Dyads

et al. 2021

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A growing body of neurobiological and psychological research sheds light on the mechanisms underlying the development and maintenance of opioid use disorder and its relation to parenting behavior. Perinatal opioid use is associated with risks for women and children, including increased risk of child maltreatment. Drawing from extant data, here we provide an integrated mechanistic model of perinatal opioid use, parenting behavior, infant attachment, and child well-being to inform the development and adaptation of behavioral interventions for opioid-exposed mother–infant dyads. The model posits that recurrent perinatal opioid use may lead to increased stress sensitivity and reward dysregulation for some mothers, resulting in decreased perceived salience of infant cues, disengaged parenting behavior, disrupted infant attachment, and decreased child well-being. We conclude with a discussion of Mindfulness-Oriented Recovery Enhancement as a means of addressing mechanisms undergirding perinatal opioid use, parenting, and attachment, presenting evidence on the efficacy and therapeutic mechanisms of mindfulness. As perinatal opioid use increases in the United States, empirically informed models can be used to guide treatment development research and address this growing concern.

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“…Our model builds on preclinical research that has shown reciprocal balancing of maternal care versus defensive/aggressive behaviors critical to healthy and safe child outcomes 17 . In the regulation of maternal behavior, many areas in the MBN (Figure 1) are sensitive to modulation by exogenous opioids, including the hypothalamus (HYP) and periaqueductal gray (PAG), 18,44,45 extended amygdala, the bed nucleus of the stria terminalis, 46 insula, orbitofrontal cortex, and anterior cingulate cortex (ACC)/medial prefrontal cortex 47–49 . In humans, the putamen is important to both maternal mentalizing 50–52 and generalized motivated behavior in addiction 53 .…”

Section: Introductionmentioning

confidence: 99%

Brain circuits for maternal sensitivity and pain involving anterior cingulate cortex among mothers receiving buprenorphine treatment for opioid use disorder

Swain

2023

J Neuroendocrinology

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Opioid‐induced deficits in maternal behaviors are well‐characterized in rodent models. Amid the current epidemic of opioid use disorder (OUD), prevalence among pregnant women has risen sharply. Yet, the roles of buprenorphine replacement treatment for OUD (BT/OUD) in the brain functions of postpartum mothers are unclear. Using functional magnetic resonance imaging (fMRI), we have developed an evolutionarily conserved maternal behavior neurocircuit (MBN) model to study human maternal care versus defensive/aggressive behaviors critical to mother–child bonding. The anterior cingulate gyrus (ACC) is not only involved in the MBN for mother–child bonding and attachment, but also part of an opioid sensitive “pain‐matrix”. The literature suggests that prescription opioids produce physical and emotional “analgesic” effects by disrupting specific resting‐state functional connectivity (rs‐FC) of ACC to regions related to MBN. Thus, in this longitudinal study, we report findings of overlapping MBN and pain matrix circuits, for mothers with chronic exposure of BT/OUD. A total of 32 mothers were studied with 6 min rs‐FC at 1 month (T1) and 4 months postpartum (T2), including seven on BT/OUD and 25 non‐BT/OUD mothers as a comparison group. We analyzed rs‐FC between the insula, putamen, and the dorsal anterior cingulate cortex (DACC) and rostral ACC (RACC), as the regions of interest that mediate opioid analgesia. BT/OUD mothers, as compared to non‐BT/OUD mothers, showed less left insula‐RACC rs‐FC but greater right putamen‐DACC rs‐FC at T1, with these between‐group differences diminished at T2. Some of these rs‐FC results were correlated with the scores of postpartum parental bonding questionnaire. We found time‐by‐treatment interaction effects on DACC and RACC‐dependent rs‐FC, potentially identifying brain mechanisms for beneficial effects of BT, normalizing dysfunction of maternal brain and behavior over the first four months postpartum. This study complements recent studies to ascertain how BT/OUD affects maternal behaviors, mother–child bonding, and intersubjectivity and reveals potential MBN/pain‐matrix targets for novel interventions.

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Opioid use during pregnancy can impair maternal behavior and the Maternal Brain Network: A literature review

Cited by 15 publications

References 209 publications

The Neurobiology of Behavior and Its Applicability for Animal Welfare: A Review

The Neurobiology of Behavior and Its Applicability for Animal Welfare: A Review

An Integrated Mechanistic Model of Mindfulness-Oriented Recovery Enhancement for Opioid-Exposed Mother–Infant Dyads

Brain circuits for maternal sensitivity and pain involving anterior cingulate cortex among mothers receiving buprenorphine treatment for opioid use disorder

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