Opioids

Koob, George F.

doi:10.1016/b978-0-12-386937-1.00005-2

Cited by 3 publications

(1 citation statement)

References 6 publications

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“…The fact that many brain regions receiving VTA Sst neuron projections belong to the extended amygdala suggests the involvement of these neurons in the action of addictive substances, such as opioids and alcohol (Koob et al, 2014a, 2014b). We did not see any differences in locomotor responses to acute morphine administration (Fig.…”

Section: Discussionmentioning

confidence: 99%

Somatostatin-expressing neurons in the ventral tegmental area innervate specific forebrain regions and are involved in the stress response

Nagaeva

Schäfer

Lindén

et al. 2023

Preprint

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Expanding knowledge about the cellular composition of subcortical brain regions demonstrates large heterogeneity and differences from the cortical architecture. Recently, we described three subtypes of somatostatin-expressing (Sst) neurons in the mouse ventral tegmental area (VTA) and showed their local inhibitory action on the neighbouring dopaminergic neurons (Nagaeva et al., 2020). Here, we report that VTA Sst neurons also project far outside the VTA and innervate several forebrain regions that are mainly involved in the regulation of emotional behaviour. When we deleted these VTA Sst neurons several behaviours and drug effects were affected, such as home cage activity, sensitization of locomotor activity to morphine, fear conditioning responses, and reactions to inescapable stress of forced swimming, often in a sex-dependent manner. Interestingly, the majority of these Sst projecting neurons was found to express Vglut2 and Th, but not Dat. Together, these data demonstrate that VTA Sst neurons have their selective projection targets, which are distinct from the main targets of VTA dopamine neurons and involved in the regulation of a variety of behaviours mostly associated with the stress response. This, in turn, makes these VTA neurons a meaningful addition to the somatostatinergic system of the brain.

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Section: Discussionmentioning

confidence: 99%

Somatostatin-expressing neurons in the ventral tegmental area innervate specific forebrain regions and are involved in the stress response

Nagaeva

Schäfer

Lindén

et al. 2023

Preprint

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Scope of the Pain Problem

Chinn

Gritsenko

Manchikanti

2016

Controlled Substance Management in Chronic Pain

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Intact responses to non-drug rewards in long-term opioid maintenance treatment

Eikemo

Lobmaier

Pedersen

et al. 2019

Neuropsychopharmacol.

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Disruption of non-drug reward processing in addiction could stem from long-term drug use, addiction-related psychosocial stress, or a combination of these. It remains unclear whether long-term opioid maintenance treatment (OMT) disrupts reward processing. Here, we measured subjective and objective reward responsiveness in 26 previously heroin-addicted mothers in >7 years stable OMT with minimal psychosocial stress and illicit drug use. The comparison group was 30 healthy age-matched mothers (COMP). Objective reward responsiveness was assessed in a two-alternative forced-choice task with skewed rewards. Results were also compared to performance from an additional 968 healthy volunteers (meta-analytic approach). We further compared subprocesses of reward-based decisions across groups using computational modelling with a Bayesian drift diffusion model of decision making. Self-reported responsiveness to non-drug rewards was high for both groups (means: OMT = 6.59, COMP = 6.67, p = 0.84, BF 10 = 0.29), yielding moderate evidence against subjective anhedonia in this OMT group. Importantly, the mothers in OMT also displayed robust reward responsiveness in the behavioral task (t 19 = 2.72, p = 0.013, BF 10 = 3.98; d = 0.61). Monetary reward changed their task behavior to the same extent as the local comparison group (reward bias OMT = 0.12, COMP = 0.12, p = 0.96, BF 10 = 0.18) and in line with data from 968 healthy controls previously tested. Computational modelling revealed that long-term OMT did not even change decision subprocesses underpinning reward behavior. We conclude that reduced sensitivity to rewards and anhedonia are not necessary consequences of prolonged opioid use.

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Opioids

Cited by 3 publications

References 6 publications

Somatostatin-expressing neurons in the ventral tegmental area innervate specific forebrain regions and are involved in the stress response

Somatostatin-expressing neurons in the ventral tegmental area innervate specific forebrain regions and are involved in the stress response

Scope of the Pain Problem

Intact responses to non-drug rewards in long-term opioid maintenance treatment

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