Opioids and matrix metalloproteinases: the influence of morphine on MMP-9 production and cancer progression

Khabbazi, Samira; Hassanshahi, Mohammadhossein; Hassanshahi, Alireza; Peymanfar, Yaser; Su, Yu Wen; Chen, Xian

doi:10.1007/s00210-019-01613-6

Cited by 17 publications

(7 citation statements)

References 113 publications

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“…Similarly, morphine precondition was found to prevent the deleterious effects of LPS on microglia cells (Gwak et al, 2010). Previous data could be explained by a mu Y. L. Chen et al, 2006;Eisenstein, 2019;Franchi et al, 2012;Khabbazi et al, 2019;P. Zhang et al, 2020).…”

Section: Discussionmentioning

confidence: 77%

IκB kinase inhibition remodeled connexins, pannexin‐1, and excitatory amino‐acid transporters expressions to promote neuroprotection of galantamine and morphine

Magdy

Gamal

Samir

et al. 2021

Journal Cellular Physiology

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Inflammatory pathway and disruption in glutamate homeostasis join at the level of the glia, resulting in various neurological disorders. In vitro studies have provided evidence that membrane proteins connexions (Cxs) are involved in glutamate release, meanwhile, excitatory amino-acid transporters (EAATs) are crucial for glutamate reuptake (clearance). Moreover, pannexin-1 (Panx-1) activation is more detrimental to neurons. Their expression patterns during inflammation and the impacts of IκB kinase (IKK) inhibition, morphine, and galantamine on the inflammatory-associated glutamate imbalance remain elusive.To investigate this, rats were injected with saline or lipopolysaccharide.Thereafter, vehicles, morphine, galantamine, and BAY-117082 were administered in different groups of animals. Subsequently, electroencephalography, enzyme-linked immunosorbent assay, western blot, and histopathological examinations were carried out and various indicators of inflammation and glutamate level were determined. Parallel analysis of Cxs, Panx-1, and EAAts in the brain was performed. Our findings strengthen the concept that unregulated expressions of Cxs, Panx-1, and EAATs contribute to glutamate accumulation and neuronal cell loss. Nuclear factor-kB (NF-κB) pathway can significantly contribute to glutamate homeostasis via modulating Cxs, Panx-1, and EAATs expressions. BAY-117082, via inhibition of IkK, promoted the antiinflammatory effects of morphine as well as galantamine. We concluded that NF-κB is an important component of reshaping the expressions of Cxs, panx-1, and EAATs and the development of glutamate-induced neuronal degeneration.

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Section: Discussionmentioning

confidence: 77%

IκB kinase inhibition remodeled connexins, pannexin‐1, and excitatory amino‐acid transporters expressions to promote neuroprotection of galantamine and morphine

Magdy

Gamal

Samir

et al. 2021

Journal Cellular Physiology

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“…Opioids have been ascribed with pro-tumorigenic effects, such as stimulating tumor cell migration by the activation of MMPs, activation of the oncogene c-MYC and inhibition of anti-angiogenic TSP-1. 177–179 Alternative techniques such as “opioid-free-anesthesia”, a specific protocol mixing local anesthetics, ketamine, magnesium and dexmedetomidine, are emerging for the management of acute pain during the per-operative period. In this setting, due to their anti-tumor effect and immunostimulatory properties, β-blockers appear as an appealing option for opioid replacement.…”

Section: Discussionmentioning

confidence: 99%

Trial watch: beta-blockers in cancer therapy

Carnet Le Provost,

Kepp,

Kroemer

et al. 2023

OncoImmunology

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Compelling evidence supports the hypothesis that stress negatively impacts cancer development and prognosis. Irrespective of its physical, biological or psychological source, stress triggers a physiological response that is mediated by the hypothalamic-pituitary-adrenal axis and the sympathetic adrenal medullary axis. The resulting release of glucocorticoids and catecholamines into the systemic circulation leads to neuroendocrine and metabolic adaptations that can affect immune homeostasis and immunosurveillance, thus impairing the detection and eradication of malignant cells. Moreover, catecholamines directly act on β-adrenoreceptors present on tumor cells, thereby stimulating survival, proliferation, and migration of nascent neoplasms. Numerous preclinical studies have shown that blocking adrenergic receptors slows tumor growth, suggesting potential clinical benefits of using β-blockers in cancer therapy. Much of these positive effects of β-blockade are mediated by improved immunosurveillance. The present trial watch summarizes current knowledge from preclinical and clinical studies investigating the anticancer effects of β-blockers either as standalone agents or in combination with conventional antineoplastic treatments or immunotherapy.

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“…Optimal pain relief is also critical for patients to reduce surgical stress and participate in early mobilization after any surgery ( 61 ). Although opioids are still widely used in surgery ( 10 ), the influence of opioids, such as morphine, on cancer progression is controversial ( 62 ). In the context of the opioid crisis and the highly restrictive use of opioids in the ERAS strategy, the risk of undertreatment of acute pain and the development of persistent chronic pain after surgery is rising.…”

Section: Discussionmentioning

confidence: 99%

Effect of acupuncture inclusion in the enhanced recovery after surgery protocol on tumor patient gastrointestinal function: a systematic review and meta-analysis of randomized controlled studies

Chen,

Fu,

Liu

et al. 2023

Front. Oncol.

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IntroductionAcupuncture has been shown to be effective in restoring gastrointestinal function in tumor patients receiving the enhanced recovery after surgery (ERAS) protocol. The present systematic review and meta-analysis aimed to evaluate the rationality and efficacy of integrating acupuncture in the ERAS strategy to recuperate gastrointestinal function.MethodsWe searched eleven databases for relevant randomized clinical trials (RCTs) of acupuncture for the treatment of gastrointestinal dysfunction in tumor patients treated with the ERAS protocol. The quality of each article was assessed using the Cochrane Collaboration risk of bias criteria and the modified Jadad Scale. As individual symptoms, the primary outcomes were time to postoperative oral food intake, time to first flatus, time to first distension and peristaltic sound recovery time (PSRT). Pain control, adverse events, and acupoint names reported in the included studies were also investigated.ResultsOf the 211 reviewed abstracts, 9 studies (702 patients) met eligibility criteria and were included in the present systematic review and meta‑analysis. Compared to control groups, acupuncture groups showed a significant reduction in time to postoperative oral food intake [standardized mean difference (SMD) = -0.77, 95% confidence interval (CI) -1.18 to -0.35], time to first flatus (SMD=-0.81, 95% CI -1.13 to -0.48), time to first defecation (SMD=-0.91, 95% CI -1.41 to -0.41, PSRT (SMD=-0.92, 95% CI -1.93 to 0.08), and pain intensity (SMD=-0.60, 95% CI -0.83 to -0.37).The Zusanli (ST36) and Shangjuxu (ST37) acupoints were used in eight of the nine included studies. Adverse events related to acupuncture were observed in two studies, and only one case of bruising was reported. DiscussionThe present systematic review and meta‑analysis suggested that acupuncture significantly improves recovery of gastrointestinal function and pain control in tumor patients receiving the ERAS protocol compared to the control group. Moreover, ST36 and ST37 were the most frequently used acupoints. Although the safety of acupuncture was poorly described in the included studies, the available data suggested that acupuncture is a safe treatment with only mild side effects. These findings provide evidence-based recommendations for the inclusion of acupuncture in the ERAS protocol for tumor patients.Systematic review registrationhttps://www.crd.york.ac.uk/prospero/ PROSPERO, identifier CRD42023430211.

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Opioids and matrix metalloproteinases: the influence of morphine on MMP-9 production and cancer progression

Cited by 17 publications

References 113 publications

IκB kinase inhibition remodeled connexins, pannexin‐1, and excitatory amino‐acid transporters expressions to promote neuroprotection of galantamine and morphine

IκB kinase inhibition remodeled connexins, pannexin‐1, and excitatory amino‐acid transporters expressions to promote neuroprotection of galantamine and morphine

Trial watch: beta-blockers in cancer therapy

Effect of acupuncture inclusion in the enhanced recovery after surgery protocol on tumor patient gastrointestinal function: a systematic review and meta-analysis of randomized controlled studies

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