Opioids and reproduction

Seeber, Beata; Böttcher, Bettina; D'Costa, Elisabeth; Wildt, L.

doi:10.1016/bs.vh.2019.07.001

Cited by 13 publications

(6 citation statements)

References 123 publications

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“…The presence of the opioid system in peripheral reproductive tissues in both women and men is a recent revelation [ 109 ]. Specifically, researchers have reported the expression of opioid receptors in the granulosa cells of the ovarian follicle, in the oocyte, and in the human endometrium [ 56 , 110 , 111 ].…”

Section: Opioids and Female Reproductionmentioning

confidence: 99%

“…Opioid receptors are concurrently found in the somatic and germ cells of the testis. The clinical correlations of these findings include effects on follicular maturation, embryo implantation, spermatogenesis, and sexual function [ 109 ].…”

Section: Opioids and Female Reproductionmentioning

confidence: 99%

“…The endogenous opioid system also has an important role during pregnancy and parturition. In addition to its direct roles, opioids also affect the prolactin and oxytocin systems, exerting additional indirect effects [ 109 ].…”

Section: Opioids and Female Reproductionmentioning

confidence: 99%

“…In turn, the rise in opioids promotes slower GnRH pulses leading to an increase in LH pulse amplitude. The frequency of GnRH and LH pulses is reduced in the luteal phase, caused by a high opioid tone induced through high progesterone levels [ 109 ]. A study with 131 healthy volunteers corroborated the postulated interaction, in which it was shown that β-endorphin levels, one of the endogenous opioid peptides which mainly act on µ-opioid receptors, increase during the follicular phase, reaching a maximum approximately 4 days before ovulation.…”

Section: Opioids and Female Reproductionmentioning

confidence: 99%

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Endometriosis and Opioid Receptors: Are Opioids a Possible/Promising Treatment for Endometriosis?

Guan

Velho²,

Sehouli³

et al. 2023

IJMS

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Endometriosis (EM), defined as the presence of endometrial-like tissue with surrounding smooth muscle cells outside the uterus, is a disregarded gynecological disease reported to affect 6–10% of women of reproductive age, with 30–50% of them suffering from chronic pelvic pain and infertility. Since the exact pathogenic mechanisms of EM are still unclear, no curative therapy is available. As pain is an important factor in EM, optimal analgesia should be sought, which to date has been treated primarily with non-steroidal anti-inflammatory drugs (NSAIDs), metamizole or, in extreme cases, opioids. Here, we review the pain therapy options, the mechanisms of pain development in EM, the endogenous opioid system and pain, as well as the opioid receptors and EM-associated pain. We also explore the drug abuse and addiction to opioids and the possible use of NOP receptors in terms of analgesia and improved tolerability as a target for EM-associated pain treatment. Emerging evidence has shown a promising functional profile of bifunctional NOP/MOP partial agonists as safe and nonaddictive analgesics. However, until now, the role of NOP receptors in EM has not been investigated. This review offers a thought which still needs further investigation but may provide potential options for relieving EM-associated pain.

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Section: Opioids and Female Reproductionmentioning

confidence: 99%

Section: Opioids and Female Reproductionmentioning

confidence: 99%

Section: Opioids and Female Reproductionmentioning

confidence: 99%

Section: Opioids and Female Reproductionmentioning

confidence: 99%

See 2 more Smart Citations

Endometriosis and Opioid Receptors: Are Opioids a Possible/Promising Treatment for Endometriosis?

Guan

Velho²,

Sehouli³

et al. 2023

IJMS

View full text Add to dashboard Cite

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“…Women are a separate cohort of patients who require the close attention of doctors due to the unique effects of drugs on their bodies [3,4]. Due to the peculiarities of their structure, namely, a higher ratio of fat to water and lower enzyme activity, drugs have a devastating effect on the female body, affecting almost all organs and systems [5]. Of particular interest among specialists of various profiles, and primarily among obstetricians and gynaecologists, is the impact of excessive drug use or long-term use of narcotic analgesics on the reproductive system, given the rapid increase in the proportion of diseases of this system and their complications [6,7].…”

Section: морфологія / Morphology Connection Of the Publication With P...mentioning

confidence: 99%

Morphometric Analysis of Changes of the Mucosa of Uterine Tube of Female Rat Under the Influence of Opioid in Experiment

Podoliuk,

Hresko,

Bekesevych

et al. 2023

VPBM

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Вісник проблем біології і медицини -2023 -Вип. 4 (171) / Bulletin of problems in biology and medicine -2023 -Issue 4 (171) 360 МОРФОЛОГІЯ / MORPHOLOGYincreased to 231.85±18.3 μm, which we also considered a negative effect of cadmium on vascular liver parenchyma system. Compared to the control, the difference in the diameter of the central lobular vein was significant (р≤0.001).Conclusions. Chronic exposure to cadmium chloride at a dose of 2.0 mg/kg led to changes in the morphological structure of the liver of experimental animals, which was manifested by a significant increase in the thickness of the liver capsule, an increase in the diameter of blood vessels with local hemorrhages in the parenchyma of the organ (on the 30th day of the experiment), an increase in the number connective tissue elements and parenchyma compaction in an experiment on rats. Chronic administration of cadmium chloride to rats leads to an increase in the activity of aspartate aminotransferase and alanine aminotransferase in the blood of male rats compared to the control group at both time points of the study, which was confirmed by the calculation of the de Ritis coefficient and indicates the negative effect of cadmium on the histogenesis of the liver of experimental animals.

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