Opioids in obstetrics: which route of administration with which opioid do we choose to establish effective analgesia?

Marcus, Marco A. E.; Gogarten, W.; Aken, Hugo Van

doi:10.1111/j.0265-0215.1998.00259.x

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Clinical Use Of Opioids In Obstetrics1

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2010

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“…Intrathecal and epidural administration of opioids by anesthesiologists is a common analgesic method used in active labor. Sufentanil and fentanyl are widely used for this purpose 36 , 37 . However, labor epidurals are given only in active labor (greater than or equal to 4 cm dilation).…”

Section: Clinical Use Of Opioids In Obstetricsmentioning

confidence: 99%

Opioid Modulation of Oxytocin Release

Morris

Domino

2010

The Journal of Clinical Pharma

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Analgesia or anesthesia is frequently used for women in labor. A wide range of opioid analgesics with vastly different pharmacokinetics, potencies, and potential side effects can be considered by physicians and midwives for laboring patients requesting pain relief other than a labor epidural. The past 50 years have seen the use of the classic mu opioid agonist morphine and other opioids diminish markedly for several reasons, including availability of epidural anesthetics, side effects, formulary restrictions, and concern for neonatal respiratory depression. Morphine is now primarily used in obstetrics to provide rest and sedation as appropriate for the stressed prodromal stages of a labor without sufficient cervical dilatation. This review discusses the scientific basis for opioid modulation of oxytocin release from the posterior pituitary and the practical implications of this relationship to explain well-known clinical observations of the effect of morphine on prodromal labor.

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Section: Clinical Use Of Opioids In Obstetricsmentioning

confidence: 99%