Opiorphin in burning mouth syndrome patients: a case-control study

Salarić, Ivan; Sabalić, Maja; Alajbeg, Ivan

doi:10.1007/s00784-016-2031-9

Cited by 31 publications

(52 citation statements)

References 34 publications

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“…Although declarative in nature, to our knowledge, no study to date has compared opiorphin to healthy children with and without self-declared past 10 Mediators of Inflammation distressing events. OPI has been described as a potent endogenous antinociceptive [67] and stress-related peptide [28,30,67] in adults. Similarly, in female adolescents affected by eating disorders, salivary changes in OPI and sIgA were observed, suggesting a possible use of OPI as a neurobiological salivary biomarker of malnutrition [27].…”

Section: Discussionmentioning

confidence: 99%

“…Opiorphin (OPI) is a polypeptide recently discovered in human saliva, increasing the bioavailability of enkephalins acting on μand δ-opioid receptors in the central nervous system (CNS), therefore displaying analgesic and antidepressant properties [16][17][18][19][20][21][22][23][24][25]. Salivary OPI secretion depends on ovarian cycles and hormonal status [18], which are known to affect the trophism of oral tissues [26][27][28][29]. OPI also plays a role in oral pain [26,28,30] and mental stress [27].…”

Section: Introductionmentioning

confidence: 99%

“…Salivary OPI secretion depends on ovarian cycles and hormonal status [18], which are known to affect the trophism of oral tissues [26][27][28][29]. OPI also plays a role in oral pain [26,28,30] and mental stress [27].…”

Section: Introductionmentioning

confidence: 99%

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Salivary Biomarkers (Opiorphin, Cortisol, Amylase, and IgA) Related to Age, Sex, and Stress Perception in a Prospective Cohort of Healthy Schoolchildren

Krahel

Paszyńska

Otulakowska-Skrzynska

et al. 2021

Mediators of Inflammation

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Background. The use of easily accessible biomarkers for assessing young patients’ health is weighty. This cohort study is aimed at measuring stress/immune biomarkers in the saliva of healthy school-age children and comparing subgroups according to age, sex, and stress perception. Material and Methods. 503 children under 12 years old ( 8.7 ± 1.3 ) were included with anthropometric evaluation (height, waist, hip circumference, body weight, and body mass index (BMI)). Levels of opiorphin (OPI), free cortisol, alpha-amylase (sAA), and secreted immunoglobulin (sIgA) were determined by quantitative assays (ELISA) in unstimulated saliva. Unpaired t -test, Welch test, and Mann–Whitney U test were applied for appropriate group comparisons, and the correlation between variables was analyzed with Spearman’s rank coefficient. Results were considered significant at p < 0.05 . Results. sIgA and sAA exhibited significant differences depending on age and sex: IgA (ng/mL): 86 ± 68.6 vs. 104.9 ± 72.1 for (6-7 y.o.) and (8-11 y.o.), respectively, and 108.1 ± 80.1 vs. 94.6 ± 62.2 for male and females, respectively; sAA (U/mL): 78.9 ± 54.4 vs. 100.5 ± 81.2 for (6-7 y.o.) and (8-11 y.o.). No difference related to age or sex between groups was observed for cortisol and OPI. However, OPI levels were higher and correlated to prior stress exposure in children ( 0.31 ± 0.4 vs. 0.26 ± 0.5 ng / mL , p = 0.031 ). sAA was negatively correlated to low mood self-declaration in children in the last two weeks ( r = − 0.10 , p = 0.045 ). Conclusions. sIgA and sAA can be used as sex- and age-related biomarkers in children 6-12 y.o., which is not the case for free cortisol and opiorphin. However, OPI reflected previous exposure to stress, suggesting its use for evaluating stress-related changes in children

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Salivary Biomarkers (Opiorphin, Cortisol, Amylase, and IgA) Related to Age, Sex, and Stress Perception in a Prospective Cohort of Healthy Schoolchildren

Krahel

Paszyńska

Otulakowska-Skrzynska

et al. 2021

Mediators of Inflammation

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“…Saliva and serum were sampled before any surgical procedure between 7 and 9 a.m. in a dark room (< 3 lux). All samples were obtained in the same conditions and by using the specially designed saliva collecting apparatus [26]. Unstimulated and stimulated saliva samples were obtained from every subject.…”

Section: Saliva and Serum Samplingmentioning

confidence: 99%

Salivary Melatonin in Oral Squamous Cell Carcinoma Patients: A Cross-sectional Study

Salarić

Karmelić

Lovrić

et al. 2020

Preprint

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BACKGROUND: Around 55% of oral squamous cell carcinoma (OSCC) patients are diagnosed in the advanced stage. Poor sleep quality has been associated as a potential risk factor for several malignancies, including head and neck cancers. Melatonin’s role in circadian rhythm is well documented, as are its’ anti-oxidant, oncostatic and anti-inflammatory properties. The purpose of this study is to determine salivary melatonin (MLT) levels in OSCC patients, compare the salivary MLT levels with those in healthy individuals and compare the salivary and serum levels in OSCC patients. Furthermore, the aim is to evaluate sleep quality and to investigate the potential relationship between sleep quality and salivary MLT levels in OSCC patients. METHODS: Unstimulated and stimulated saliva were sampled from patients with T1N0M0 and T2N0M0 OSCC (N=34) and 33 sex and age matched healthy subjects. Serum samples were taken from 11 OSCC patients. Detailed medical history was taken before sampling and sleep quality measured using Pittsburgh Sleep Quality Index (PSQI) questionnaire. RESULTS: Melatonin levels in UWS and SWS were significantly higher in the OSCC group. Sleep quality was significantly lower in patients with OSCC (U=249.50; P = 0.0001). ROC analysis was found to be significant (P <0.001) in evaluating the MLT concentration limit in diagnosing OSCC. CONCLUSIONS: The expected relationship between sleep quality and salivary MLT levels in OSCC patients was not observed. Salivary melatonin could present a potential OSCC biomarker. However, larger prospective studies should validate the clinical utility of MLT as an OSCC biomarker.

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“…However, the direct role of opiorphin in BMS is not supported although its blood levels may indicate a systemic deregulation in these patients. [18][19][20]…”

Section: And Therapeutic Implicationmentioning

confidence: 99%

An analgesic to bridge the gap between Narcotics and NSAIDs: opiorphin

Sujatha¹,

Priyadharshini²,

Nejad³

et al. 2018

Int J Basic Clin Pharmacol

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Pain management is an all-time challenge in dentistry. Discontent to pain management is a concern among patients and professionals. Unrelieved pain affects physical and mental well-being contributing to delayed recovery, psychological distress and anxiety. Studies have revealed that chronic pain interferes with normal daily chores of the individual like exercise, sleep, social life and lifestyle. At one end of pain management spectrum are Non-steroidal anti-inflammatory drugs (NSAIDs) while at the other end are the opioids. These drugs are not without constituent side effects. The quest is for new analgesics with potent and long term analgesia with minimal or no side effects. An analgesic that is intermediate in this spectrum is the need of the hour. Opiorphin is an endogenous peptide isolated from human saliva. Opiorphin produces analgesia, by inhibiting enkephalin (ENK) metabolizing enzymes, thus increasing the half-life of circulating ENKs. Apart from being a potent analgesic it can also be a potential biomarker for various systemic and psychosocial disorders. This review focuses on the pharmacological effects of opiorphin and its potential role as a biomarker in various disease conditions.

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Opiorphin in burning mouth syndrome patients: a case-control study

Cited by 31 publications

References 34 publications

Salivary Biomarkers (Opiorphin, Cortisol, Amylase, and IgA) Related to Age, Sex, and Stress Perception in a Prospective Cohort of Healthy Schoolchildren

Salivary Biomarkers (Opiorphin, Cortisol, Amylase, and IgA) Related to Age, Sex, and Stress Perception in a Prospective Cohort of Healthy Schoolchildren

Salivary Melatonin in Oral Squamous Cell Carcinoma Patients: A Cross-sectional Study

An analgesic to bridge the gap between Narcotics and NSAIDs: opiorphin

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