Opisthorchis felineus infection and cholangiocarcinoma in the Russian Federation: A review of medical statistics

Федорова, О. С.; Kovshirina, Yulia V.; Kovshirina, Anna E.; Федотова, М М; Deev, I.A.; Petrovskiy, Fedor; Филимонов, А. В.; Дмитриева, А. И.; Kudyakov, L A; Saltykova, Irina V.; Odermatt, Peter; Огородова, Л. М.

doi:10.1016/j.parint.2016.07.010

Cited by 50 publications

(46 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Opisthorchis felineus is found in the former USSR including Belarus and Ukraine and has been found in animals in Germany, Italy, Poland, Portugal, and Spain over the last 50 years (5,16) . Locally transmitted human infection has been reported in Germany and Italy, with a recent outbreak reported from the region around Lake Bolsena (17) .…”

Section: Affected Populationsmentioning

confidence: 99%

See 1 more Smart Citation

Human liver flukes

Harrington

Lamberton

McGregor

2017

The Lancet Gastroenterology & Hepatology

View full text Add to dashboard Cite

show abstract

Section: Affected Populationsmentioning

confidence: 99%

“…felineus (16) and a high prevalence of O. felineus infection in autopsy studies of patients with primary liver malignancies (fluke infection seen in 42 of 44 liver malignancy patients in one study) (32) . Additionally there are some animal data suggesting cholangiocarcinoma as a sequalae of O. felineus infection (33) .…”

Section: Cholangiocarcinomamentioning

confidence: 99%

Human liver flukes

Harrington

Lamberton

McGregor

2017

The Lancet Gastroenterology & Hepatology

View full text Add to dashboard Cite

show abstract

“…Nevertheless, although some studies also clearly indicate an epidemiological association (Pakharukova & Mordvinov, 2016), a study investigating associations between O. felineus infection and CCA in the Russian Federation does not provide an unequivocal answer (Fedorova et al, 2017); although the incidence of liver and intrahepatic bile duct cancers (code C22 in ICD-10) was significantly higher in regions with high O. felineus infection, compared with low incidence regions, in another region with high C22 cancer incidence, new cases of the infection had not been reported. As the authors point out, however, CCA usually develops a decade or more after Opisthorchis infection, and the study is also limited by the lack of distinction between liver and bile duct cancers (Fedorova et al, 2017).…”

Section: Opisthorchis Spp: Tourism Travel and More Raw Fishmentioning

confidence: 97%

Parasites in Food: From a Neglected Position to an Emerging Issue

Robertson

2018

Advances in Food and Nutrition Research

View full text Add to dashboard Cite

Foodborne parasites have long been a neglected group of pathogens, as they often have insidious, chronic effects, rather than being acute diseases, and they are often associated with impoverished or marginalized populations. In addition, due to the long incubation period for most foodborne parasites, source attribution is often difficult, if not impossible. However, global trends have enabled foodborne parasites to emerge in different populations in new locations, transmitted through different food types, and sometimes with unexpected symptoms. This emergence of foodborne parasites has brought them into focus. In this chapter, six foodborne parasites are used as examples on emergence: Echinococcus multilocularis is spreading to new locations; Cryptosporidium spp. are beginning to be associated not only with water, but also with salads; Trypanosoma cruzi is being manifest with acute disease due to foodborne transmission, particularly transmitted with juices; Trichinella spp. have become less of a burden regarding transmission via pork in many countries, but now game animals are becoming a concern; anisakiasis is becoming a global problem as the world develops a taste for sushi, and similarly for opisthorchiasis, which is increasingly being associated with cholangiocarcinoma. However, the emergence of these foodborne parasites provides an incentive for increased efforts being made toward control. In this chapter, having described how the parasites are emerging from their neglected position, the focus turns toward control. In addition to considering control measures that may be applied to the specific parasites, an overview is provided of some of the organized collaborations, projects, and consortia, as well as some of their outputs, that have in focus the control of these emerging and important pathogens.

show abstract

“…Many CCA are adenocarcinomas (1,2). Although the causative agent for many cancers remains obscure including non-liver fluke infection-associated CCA, the principal risk factor in liver flukeendemic regions is well established: infection with Opisthorchis viverrini and related parasites (3)(4)(5)(6). Infection with O. viverrini is the principal risk factor for CCA in the Lower Mekong River Basin countries including Thailand, Lao PDR, Vietnam and Cambodia (5,6).…”

Section: Introductionmentioning

confidence: 99%

Liver fluke granulin promotes exosome-mediated crosstalk and cellular microenvironment conducive to cholangiocarcinoma

Arunsan

Chaidee

et al. 2019

Preprint

View full text Add to dashboard Cite

Crosstalk between malignant and neighboring cells contributes to tumor growth. In East Asia, infection with fish-borne liver flukes is a major risk factor for cholangiocarcinoma (CCA). The parasite secretes a growth factor termed liver fluke granulin (Ov-GRN-1), a homologue of the human progranulin (huPGRN), which contributes significantly to biliary tract fibrosis and morbidity during infection. Here, exosome-mediated transfer of mRNAs from the human cholangiocyte cell line (H69) was investigated following exposure to Ov-GRN-1, to naïve recipient H69 cells. To minimize the influence of endogenous huPGRN, the gene encoding huPGRN was inactivated using CRISPR/Cas9-based gene knock-out. Several huPGRN-depleted cell lines, termed DhuPGRN-H69, were established. These lines exhibited >80% reductions in levels of huPGRN transcripts and protein, both in gene-edited cells and within exosomes released by these cells. Profiles of exosomal RNAs (exRNA) from DhuPGRN-H69 for CCAassociated characteristics revealed a paucity of transcripts for estrogen-and Wnt-signaling pathways, peptidase inhibitors and tyrosine phosphatase related to cellular processes including oncogenic transformation. Several CCA-specific mRNAs including MAPK/AKT pathway members were induced by exposure to Ov-GRN-1. By comparison, estrogen, Wnt/PI3K and TGF signaling and other CCA pathway mRNAs were upregulated in wild type H69 exposed to Ov-GRN-1. Of these, CCA-associated exRNAs modified the CCA microenvironment in naïve recipient cells co-cultured with exosomes from DhuPGRN-H69 exposed to Ov-GRN-1, and induced translation of MAPK phosphorylation related-protein in naïve recipient cells comparing with control recipient cells. Exosome-mediated crosstalk in response to liver fluke granulin promoted a CCA-specific program through MAPK pathway which, in turn, established a CCAconducive disposition.

show abstract

Opisthorchis felineus infection and cholangiocarcinoma in the Russian Federation: A review of medical statistics

Cited by 50 publications

References 7 publications

Human liver flukes

Human liver flukes

Parasites in Food: From a Neglected Position to an Emerging Issue

Liver fluke granulin promotes exosome-mediated crosstalk and cellular microenvironment conducive to cholangiocarcinoma

Contact Info

Product

Resources

About