Opisthorchis felineus infection, risks, and morbidity in rural Western Siberia, Russian Federation

Helicobacter pylori causes a wide range of human diseases including cancer. Carcinogenic foodborne trematodes Opisthorchis viverrini, Clonorchis sinensis, and O. felineus might promote transmission and spread of H. pylori infection in the definitive mammalian host, which in turn might contribute to the liver fluke-associated malignancy. Our objectives were to find out whether liver flukes O. felineus, O. viverrini, and C. sinensis are carriers of Helicobacter pylori and to determine whether H. pylori is present in feces, bile, and stomach samples from the experimentally infected hamsters. We found that liver flukes are not reservoirs of H. pylori. Nevertheless, the prevalence of H. pylori and the H. pylori ureA gene copy number were significantly elevated after the infection. Overall, although the liver flukes O. felineus, C. sinensis, and O. viverrini are not reservoirs of H. pylori, the infection with the liver flukes significantly modifies the biliary and gut microbiota by increasing H. pylori abundance. This may be a feature of any liver fluke pathogenesis that have not previously been taken into account. Our findings appear to be novel in terms of comparative assessment of the host microbiota and Helicobacter abundance during epidemiologically important liver fluke infections.

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“…viverrini and C . sinensis 2 , 5 , and this species is recognized as a potentially dangerous agent (Group 2B) 4 .…”

Section: Introductionmentioning

confidence: 99%

A comparative study of Helicobacter pylori infection in hamsters experimentally infected with liver flukes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis

Pakharukova

Zaparina

Hong

et al. 2021

Sci Rep

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“…The prevalence still high and require the prevention and control program as a recommendation. (Fedorova et al, 2020). The prevalence of Opisthorchiasis among inhabitant in Cambodia (2006-2011) already revealed with minute intestinal fluke showed 5.7 % (1838 from 32,201), the most prevalence showed in central and southern regions showed 14.7 % (1,575 from 10,721) the outcome showed national program still require are prevention and control.…”

Section: Summary and Discussionmentioning

confidence: 94%

National Program of Opisthorchiasis in Thailand; Situation and Policy Strategy

Kitphati

Watanawong

Wongsaroj

et al. 2021

IJG

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Opisthorchiasisis, a chronic parasitic inflammatory disease of the bile ducts, caused by liver fluke or Opisthorchis viverrini infections is a crucial significant public health problem in Thailand. Most evidence of Opisthorchiasis is reported from national programs. Thus the magnitude of liver fluke infection at the national level required to assess the effectiveness of the national opisthorchiasis control program. In Thailand, infections with Opisthorchis viverrini are associated with a high mortality secondary to Cholangiocarcinoma (CCA). A systematic countrywide national survey in Thailand already reported from the past more than half-century (59 years) in 1957 to date in 2019, revealed the declining trend of the overall helminthiasis infection from 62.9% (in 1957) to 8.13% (in 2009). The National Opisthorchiasis control program managers have initiated and established a national plan to prevent and control these eradicate diseases through the interaction and responses of the provincial public health sectors. However, the national control program managers need to have information determined by evidence-based needs. These intensive data are representative of all ages of the population of Thailand and are derived from the national household survey. The national prevalence of Opisthorchis viverrini in this study was carried out in 77 provinces. A total of 9,904 samples of stool specimens were obtained from the population by using a cluster random sampling under WHO guidelines. The results of this large scale survey showed that the overall prevalence of Opisthorchaisis among Thai people was 4.0%. The highest prevalence of O. viverrini was 11.9 %, in the health region 5 in the Northeast region. During this national survey of Opisthorchiasis, geographic information is also conducted to investigate the prevalence of O. viverrini. The spatial analysis would be the trends and analyze the risk factors that correlate with infections among rural Thai people. The recommendation that already showed the impact of National program useful for every country especially in Mae King basin for elimination and control for opisthorchiasis.

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“…A close relative of O. viverrini , Opisthorchis felineus , has also been regarded as a potential human carcinogen. Epidemiological data associate infection with this fluke with severe hepatobiliary disease [ 74 ] and regard it as a risk factor for CCA [ 75 ]. However, the mechanisms by which this parasite leads to these pathologies remain unknown.…”

Section: Proteins Involved In Carcinogenesis In Other Helminthiasementioning

confidence: 99%

Spirocerca lupi Proteomics and Its Role in Cancer Development: An Overview of Spirocercosis-Induced Sarcomas and Revision of Helminth-Induced Carcinomas

et al. 2021

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Spirocerca lupi is a parasitic nematode of canids that induces a myriad of clinical manifestations in its host and, in 25% of infections, leads to the formation of sarcomas. The description of the protein composition of the excretory and secretory products (Sl-ESP) of S. lupi has shed light on its possible interactions with the host environment, including migration within the host and mechanisms of immunomodulation. Despite this, the process by which S. lupi induces cancer in the dog remains poorly understood, and some hypotheses have arisen regarding these possible mechanisms. In this review, we discuss the role of specific ESP from the carcinogenic helminths Clonorchis sinensis, Opisthorchis viverrini and Schistosoma haematobium in inducing chronic inflammation and cancer in their host’s tissues. The parasitic worms Taenia solium, Echinococcus granulosus, Heterakis gallinarum, Trichuris muris and Strongyloides stercoralis, which have less-characterized mechanisms of cancer induction, are also analyzed. Based on the pathological findings in spirocercosis and the mechanisms by which other parasitic helminths induce cancer, we propose that the sustained inflammatory response in the dog´s tissues produced in response to the release of Sl-ESP homologous to those of other carcinogenic worms may lead to the malignant process in infected dogs.

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Opisthorchis felineus infection, risks, and morbidity in rural Western Siberia, Russian Federation

Cited by 47 publications

References 36 publications

A comparative study of Helicobacter pylori infection in hamsters experimentally infected with liver flukes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis

A comparative study of Helicobacter pylori infection in hamsters experimentally infected with liver flukes Opisthorchis felineus, Opisthorchis viverrini, or Clonorchis sinensis

National Program of Opisthorchiasis in Thailand; Situation and Policy Strategy

Spirocerca lupi Proteomics and Its Role in Cancer Development: An Overview of Spirocercosis-Induced Sarcomas and Revision of Helminth-Induced Carcinomas

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