Opisthorchis viverrini antigens up-regulates the expression of CD80 and MHC class II in JAWSII mouse dendritic cells and promotes IL-10 and TGF-β secretions

Jittimanee, Suphattra; Wongratanacheewin, Surasakdi; Kaewraemruaen, Chamraj; Jittimanee, Jutharat

doi:10.1016/j.parint.2021.102401

Cited by 5 publications

(5 citation statements)

References 32 publications

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“…In addition, dendritic cells enhance the expression of co‐stimulatory molecules such as CD80 and CD86, and they secrete pro‐inflammatory cytokines, establishing an immunogenic milieu. [ 34 ] We co‐cultured primary DCs from the mouse bone marrow and MB49 cells pretreated for 24 h to verify the effectiveness of MIL‐53@CM‐272 + US in stimulating APC maturation Figure a. Subsequently, the developmental status of the accumulated DCs was evaluated using flow cytometry, and the discharge of cytokines was examined using an enzyme‐linked immunosorbent assay.…”

Section: Resultsmentioning

confidence: 99%

A “One Arrow Three Eagle” Strategy to Improve CM‐272 Primed Bladder Cancer Immunotherapy

Liu,

Yang,

et al. 2023

Advanced Materials

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Immunotherapy using an immune‐checkpoint blockade has significantly improved its therapeutic effects. CM‐272, which is a novel epigenetic inhibitor of G9a, induces immunogenic cell death (ICD) for recovering the sensitivity to anti‐PD‐1 antibodies; however, the efficacy of CM‐272 is greatly limited by promoting the transcription activity of HIF‐1α to form a hypoxic environment. Here, a Fe3+‐based nanoscale metal–organic framework (MIL‐53) is used to load CM‐272 (ultra‐high loading rate of 56.4%) for realizing an MIL‐53@CM‐272 nanoplatform. After entering bladder cancer cells, Fe3+ not only promotes the decomposition of H2O2 into O2 for O2‐compensated sonodynamic therapy but reduces the high level of glutathione in the tumor microenvironment (TME) for enhancing reactive oxygen species, including ferroptosis and apoptosis. MIL‐53 carriers can be degraded in response to the TME, accelerating the release of CM‐272, which helps achieve the maximum effectiveness in an O2‐sufficient TME by attenuating drug resistance. Furthermore, MIL‐53@CM‐272 enhances dendritic cell maturation and synergistically combines it with an anti‐programmed cell death protein 1 antibody during the study of immune‐related pathways in the transcriptomes of bladder cancer cells using RNA‐seq. This study presents the first instance of amalgamating nanomedicine with CM‐272, inducing apoptosis, ferroptosis, and ICD to achieve the “one arrow three eagle” effect.

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Section: Resultsmentioning

confidence: 99%

A “One Arrow Three Eagle” Strategy to Improve CM‐272 Primed Bladder Cancer Immunotherapy

Liu,

Yang,

et al. 2023

Advanced Materials

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“…For example, a study by Jittimanee et al showed that CS and ES antigens induce mRNA expressions and an increase in protein levels of CD80 and MHC class II, both of which play an important role in dendritic cell maturation and T cell activation, leading to a pro-inflammatory state. However, the same antigens are also found to be able to stimulate the production of large amounts of interleukin-10 (IL-10) and transforming growth factor beta (TGF-β) concurrently, which are immunosuppressive in nature [ 43 ].…”

Section: Hepatobiliary Opisthorchiasismentioning

confidence: 99%

“…interleukin-10 (IL-10) and transforming growth factor beta (TGF-β) concurrently, which are immunosuppressive in nature [43].…”

Section: Hepatobiliary Opisthorchiasismentioning

confidence: 99%

Opisthorchis viverrini—Current Understanding of the Neglected Hepatobiliary Parasite

Liau,

Toh,

Shelat

2023

Pathogens

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Opisthorchiasis due to Opisthorchis viverrini infection continues to be a significant public healthcare concern in various subregions of Southeast Asia, particularly in Thailand, Laos, Cambodia, Myanmar, and Vietnam. The main mode of transmission is via consumption of raw or undercooked fish, which is deeply embedded in the culture and tradition of the people living near the Mekong River. After ingestion, the flukes migrate to the bile ducts, potentially causing many hepatobiliary complications, including cholangitis, cholecystitis, cholelithiasis, advanced periductal fibrosis and cholangiocarcinoma. Several mechanisms of opisthorchiasis-associated cholangiocarcinogenesis have been proposed and elucidated in the past decade, providing insight and potential drug targets to prevent the development of the sinister complication. The gold standard for diagnosing opisthorchiasis is still via stool microscopy, but the advent of novel serological, antigen, and molecular tests shows promise as more convenient, alternative diagnostic methods. The mainstay of treatment of opisthorchiasis is praziquantel, while treatment of opisthorchiasis-associated cholangiocarcinoma depends on its anatomic subtype and resectability. Thus far, the most successful fluke control programme is the Lawa model based in Thailand, which raised awareness, incorporated education, and frequent surveillance of intermediate hosts to reduce transmission of opisthorchiasis. Development of vaccines using tetraspanins shows promise and is currently ongoing.

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“…Tregs are a kind of T cells that can control the autoimmune response, which is abundant in iTME and also called immunosuppressive cells. Tregs can inhibit T cell activation and proliferation via various mechanisms, such as inhibition of MHC molecules and costimulatory molecules (CD80 and CD86) on the surface of APCs, to inhibit APCs maturation, such that they can weaken the interaction between APCs and T cells. , Additionally, APCs can also sacrifice T cells and APCs by secreting perforins and granzymes, as well as inhibit T cell activation and proliferation by secreting inhibitory cytokines (e.g., TGF-β, IL-10, IL-35) and consuming γc cytokines . Recently, B cells subset with immune regulation functions have been named regulatory B cells (Bregs).…”

Section: Target Cells Recommended For Tumor Immunotherapymentioning

confidence: 99%

Advanced Generation Therapeutics: Biomimetic Nanodelivery System for Tumor Immunotherapy

Li,

Zeng,

et al. 2023

ACS Nano

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Opisthorchis viverrini antigens up-regulates the expression of CD80 and MHC class II in JAWSII mouse dendritic cells and promotes IL-10 and TGF-β secretions

Cited by 5 publications

References 32 publications

A “One Arrow Three Eagle” Strategy to Improve CM‐272 Primed Bladder Cancer Immunotherapy

A “One Arrow Three Eagle” Strategy to Improve CM‐272 Primed Bladder Cancer Immunotherapy

Opisthorchis viverrini—Current Understanding of the Neglected Hepatobiliary Parasite

Advanced Generation Therapeutics: Biomimetic Nanodelivery System for Tumor Immunotherapy

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