Opportunistic Diseases in HIV-Infected Patients in Gabon following the Administration of Highly Active Antiretroviral Therapy: A Retrospective Study

Okome-Nkoumou, M; Guiyedi, Vincent; Ondounda, M.; Efire, Nora; Clevenbergh, Philippe; Dibo, Mireille; Dzeing-Ella, Arnaud

doi:10.4269/ajtmh.12-0780

Cited by 16 publications

(19 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The strategy for treatment of HIV/TB is initiated using empiric treatment (Kaplan et al 2009) before MTB diagnostic work-up completed which usually takes 7-8 weeks, and genetic methods for detecting MTB may be beneficial to early initiation of accurate treatment in HIV/TB patients. The existing data have shown that CD4+T cell counts are associated negatively with viral load (Papasavvas et al 2015), and CD4+T cell counts are responsible for the development of most OIs among HIV-infected individuals (Okome-Nkoumou et al 2014). In this study, CD4+T cell counts in the HIV group were lower than those in the TB group, but the difference between the TB/HIV and HIV groups was not significant.…”

Section: Discussioncontrasting

confidence: 62%

“…Global evidence has shown that the common OIs are tuberculosis (TB), Pneumocystis jiroveci pneumonia (PCP), candida infection, cytomegalovirus infection (CMV) (Saha et al 2011;Fenner et al 2013;Kim et al 2013;Katano at al. 2014;Okome-Nkoumou et al 2014). OIs cause substantial morbidity in HIV-infected patients, leading to increased economic and social burden.…”

Section: Introductionmentioning

confidence: 99%

“…The prevalence of OIs differs among various countries due to different climates and socio-economic conditions (Saha et al 2011;Fenner et al 2013;Kim et al 2013;Katano at al. 2014;Okome-Nkoumou et al 2014). The analysis of OIs could provide useful information related to pathogens and causes of death in HIV-infected patients.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Prevalence of Opportunistic Infections and Causes of Death among Hospitalized HIV-Infected Patients in Sichuan, China

Pang

Shang

et al. 2018

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

Opportunistic infections (OIs) are the most significant complication of human immunodeficiency virus (HIV) infection. The prevalence of OIs differs among various countries in part due to different climates and socio-economic conditions. We, therefore, carried out the retrospective study at the Public Health Clinical Center of Chengdu, Sichuan to comprehensively investigate the prevalence of OIs, predictors of OIs, and risk factors for in-hospital death among HIV-infected patients. Sichuan in West China is characterized by the largest population living with HIV/Acquired immunodeficiency syndrome (AIDS) across China. In total, we reviewed 954 cases of HIV infection, admitted to the hospital during January 2014 to December 2015, and found that bacterial pneumonia (25.8%) was the most common OIs, followed by candida infection (18.3%), Pneumocystis jiroveci pneumonia (11.9%), tuberculosis (11.5%), infectious diarrhoea (9.3%), cryptococcus infection (7.3%), cytomegalovirus infection (4.9%), toxoplasmosis (4.6%), hepatitis C (4.0%), nontuberculous mycobacteria desease (2.2%) and Penicillium marneffei infection (0.3%). We also found two strongest risk factors for in-hospital mortality: CD4+T cell counts of less than 100 cells/μL and not receiving antiretroviral therapy. Moreover, the study revealed the specific pathogens causing bacterial pneumonia and/or candida infection, the effect of tuberculosis on CD4+T cell counts, and the drug resistance of Mycobacterium tuberculosis among HIV-infected and non-HIV-infected patients. The present findings may aid in the clinical diagnosis and treatment of HIV-infected patients, and could help developing efficient public health strategies in China.

show abstract

Section: Discussioncontrasting

confidence: 62%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Prevalence of Opportunistic Infections and Causes of Death among Hospitalized HIV-Infected Patients in Sichuan, China

Pang

Shang

et al. 2018

Tohoku J. Exp. Med.

View full text Add to dashboard Cite

show abstract

“…However, certain individuals are at high risk for severe or life-threatening toxoplasmosis. Individuals at risk for toxoplasmosis include fetuses, newborns, and immunocompromised patients (Tenter et al 2000;Okome-Nkoumou et al 2014).…”

Section: Introductionmentioning

confidence: 99%

Effects of Toxoplasma gondii infection on anxiety, depression and ghrelin level in male rats

et al. 2014

View full text Add to dashboard Cite

The aim of the present study was to determine the effects of Toxoplasma gondii (T. gondii) infection on anxiety, depression and ghrelin level in male rats. Twenty four male rats were assessed in two equal groups. T. gondii tachyzoite (ip) were injected in infected group and control group received (2 ml) physiological serum (ip). Elevated plus Maze and swimming tests were used to assess anxiety and depression in rats respectively. The ghrelin and T. gondii IgG serum levels were measured by enzyme immunoassay kits. The Student's t test and Pearson correlation coefficient were used. The ghrelin serum level was significantly lower in the infected rats than control (P = 0.03). There were no significant differences in the depression and anxiety behavior between two groups. However, here were no significant correlations between ghrelin level and anxiety or depression in rats. It seems that latent T. gondii infection decreases the ghrelin serum level but does not change anxiety and depression like behaviors.

show abstract

“…In our documentation, we recorded about 10% of lost to follow-up over 12, or a retention rate of 90%. Such figure is similar to that found in a study conducted in the Fann's Infectious Diseases Department, a reference Department as part of caregiving for PLHIV where it was 11.1% [9]. It is significantly lower than that found in Côte d'Ivoire where a total of 33% of patients were lost to follow-up during the first 12 months of antiretroviral treatment.…”

Section: Those Lost To Follow In the First 12 Months Of Antiretroviramentioning

confidence: 31%

Evaluation of Early Warning Indicators of ARV Resistance to HIV in the Hospital of Tivaouane from 2008 to 2016

Lawson¹,

Lakhe²,

Dione³

et al. 2018

AID

View full text Add to dashboard Cite

Introduction: HIV resistance to antiretroviral is currently a global concern, and requires increased surveillance in a context of widespread ARV treatment. Objective: To evaluate early warning indicators of HIV resistance to ARVs in the Hospital of Tivaouane (Senegal) where viral load was not routinely available. Methods: This is a cross-sectional retrospective study from 2008-2016. The extraction tool (May 2010 version) was used to analyze the EWI. Results: We collected 360 HIV positive patients followed on average for 3.57 years ± 3.02. 2009, 2010 and 2012 recorded 100% ARV prescribing rates. Throughout the study period, the percentage of patients lost to follow-up during the first 12 months of treatment was less than 20%. Virtually, all patients were still under primary ARVT over 12-month treatment. All patients (100%) withdrew their ARV drugs on time. No stock storage regarding various classes of ARVs was noted during the study period. Conclusion: At the end of this study we recommend to maintain regular follow-up of EWI, and combine it with the achievement of viral load.

show abstract

Opportunistic Diseases in HIV-Infected Patients in Gabon following the Administration of Highly Active Antiretroviral Therapy: A Retrospective Study

Cited by 16 publications

References 9 publications

Prevalence of Opportunistic Infections and Causes of Death among Hospitalized HIV-Infected Patients in Sichuan, China

Prevalence of Opportunistic Infections and Causes of Death among Hospitalized HIV-Infected Patients in Sichuan, China

Effects of Toxoplasma gondii infection on anxiety, depression and ghrelin level in male rats

Evaluation of Early Warning Indicators of ARV Resistance to HIV in the Hospital of Tivaouane from 2008 to 2016

Contact Info

Product

Resources

About