Opportunistic infections in patients with pulmonary alveolar proteinosis

Punatar, Ankit D.; Kusne, Shimon; Blair, Janis E.; Seville, Maria Teresa; Vikram, Holenarasipur R.

doi:10.1016/j.jinf.2012.03.020

Cited by 96 publications

(99 citation statements)

References 40 publications

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“…Similarly, neutralizing IFN-γ and GM-CSF autoantibodies can underlie adult-onset acquired immunodeficiency characterized by endemic dimorphic fungal (143) and CNS cryptococcal disease (144). Patients with alveolar proteinosis due to impaired GM-CSF signaling develop aspergillosis (145), consistent with murine studies (146).…”

Section: Antifungal Immunity: Lessons From Fungal Disease-associated mentioning

confidence: 58%

Immunity against fungi

Lionakis¹,

Iliev²,

Hohl³

2017

JCI Insight

117

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Section: Antifungal Immunity: Lessons From Fungal Disease-associated mentioning

confidence: 58%

Immunity against fungi

Lionakis¹,

Iliev²,

Hohl³

2017

JCI Insight

117

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“…Indeed, reduced cell adhesion, phagocytosis, pathogen killing, mannose-and Toll-like receptor expression, and LPS-or peptidoglycan-stimulated TNFα release were observed in alveolar macrophages and neutrophils from GM-CSF deficient mice and PAP patients [31,35]. Accordingly, PAP patients developed respiratory and extrapulmonary infections with opportunistic pathogens such as nontuberculous mycobacteria, Histoplasma, Cryptococcus, Nocardia or fungi [35][36][37][38][39][40]. Notably, this spectrum of infections appears very similar to the phenotype associated with the presence of neutralizing anti-IFNγ AAbs [6].…”

Section: Anti-gm-csf Autoantibodiesmentioning

confidence: 99%

Emerging clinical phenotypes associated with anti-cytokine autoantibodies

Vincent

Plawecki

Goulabchand

et al. 2015

Autoimmunity Reviews

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“…Il faut les rechercher systématiquement, notamment lors des grands lavages pulmonaires thérapeutiques [10,37]. Les principaux Tableau 2 Principaux germes opportunistes compliquant les protéinoses alvéolaires pulmonaires [37]. Ces infections peuvent précéder ou suivre le diagnostic de PAP.…”

Section: éVolution Et Complicationsunclassified

La protéinose alvéolaire pulmonaire

Jouneau

Kerjouan

Briens

et al. 2014

Revue des Maladies Respiratoires

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Alveolar proteinosis (AP) is a rare disease characterized by alveolar accumulation of surfactant components, which impairs gas exchange. AP is classified into three groups: auto-immune AP defined by the presence of plasma autoantibodies anti-GM-CSF, the most frequent form (90% of all AP); secondary AP, mainly occurring as a consequence of haematological diseases, or following on from toxic inhalation or infections, and genetic AP, which affects almost exclusively children. AP diagnosis is suspected where chest CT-scan demonstrates interstitial lung disease with a crazy paving aspect; and confirmed by bronchoalveolar lavage, which has a milky appearance and contains periodic acid Schiff positive proteinaceous alveolar deposits. The use of surgical lung biopsy to confirm AP is less frequent nowadays. In this context, positive antibodies against GM-CSF indicates an auto-immune etiology of the AP. Concerning management, whole lung lavage is the gold standard therapy. In refractory AP, new treatments are available such as subcutaneous or inhaled GM-CSF supplementation, or rituximab infusions. The clinical course is unpredictable. Spontaneous improvement or even cure can occur, and the 5-year actuarial survival is 95%. The most frequent complications are infectious etiology.

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Opportunistic infections in patients with pulmonary alveolar proteinosis

Cited by 96 publications

References 40 publications

Immunity against fungi

Immunity against fungi

Emerging clinical phenotypes associated with anti-cytokine autoantibodies

La protéinose alvéolaire pulmonaire

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