OPPORTUNISTIC INFECTIONS IN PEDIATRIC HIV INFECTION: A study of 74 Autopsy Cases from Latin America

Drut, Ricardo; Greco, M. Alba; Gutiérrez, Carmen; León-Bojorge, Beatríz de; Menezes, Dora; Peruga, Armando; Quijano, Graciela; Ridaura, Cecilia; Siminovich, Mónica; Valencia, Pedro José Lozano; Weissenbacher, Mercedes

doi:10.1080/107710497174534

Cited by 22 publications

(7 citation statements)

References 4 publications

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“…This ® nding was reported in a previously published series of children with AIDS [ 8,9 ] . Other factors such as a more virulent CMV strain or younger age, with perhaps a more impaired immune function, may play a role.…”

Section: Discussionsupporting

confidence: 83%

Liver Pathology in Children With Aids: A Comparison Between the South American and North American Population

Morotti¹

2001

Pediatric Pathology & Molecular Medicine

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& Liver tissue from autopsies of twenty-nine cases of children with AIDS were collected from three major South America (SA) pediatric hospitals. The hepatopathologic ® ndings were classi® ed in the same fashion as in a series of sixty-one children with AIDS from North America (NA): in¯ammation, non-speci® c, lymphoproliferative disorders, and giant cell transformation. By comparing both groups, we noted that the SA children were younger at time of death consistent with a more rapid progression of the disease. Opportunistic infections varied with a higher prevalence of Cytomegalovirus (CMV) infection in SA children. The histopathologic features of CMV in the liver of SA children were associated with a conspicuous in¯ammation absent in the NA group. Finally, diÚ erent non-speci® c hepatic changes were found in SA children, including one case of peliosis hepatis.Many histologic alterations are associated with symptomatic human immuno-de® ciency virus (HIV) infection. Some are related directly to the virus, others are secondary to the immunode® ciency status such as neoplasms and opportunistic infections, or toxic eÚ ects due to therapy. 542 R. A. Morotti et al.FIGURE 4. Peliosis hepatis characterized by a nodular mass with ectatic sinusoids. Hematoxylin-eosin X250.Liver Pathology in Children with AIDS 545

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Section: Discussionsupporting

confidence: 83%

Liver Pathology in Children With Aids: A Comparison Between the South American and North American Population

Morotti¹

2001

Pediatric Pathology & Molecular Medicine

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“…Liver involvement by CMV in SA and NA children was associated with disseminated infection. This ¢nding was reported in a previously published series of children with AIDS [8,9]. Hepatocellular giant cell transformation in CMV infection has also been noted by others [2,10].…”

Section: Discussionsupporting

confidence: 81%

Liver Pathology in Children With Aids: A Comparison Between the South American and North American Population

Morotti¹,

Tata²,

Drut³

et al. 2002

Pediatric Pathology & Molecular Medicine

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Liver tissue from autopsies of 29 cases of children with acquired immunode¢ciency syndrome (AIDS) were collected from three major South America (SA) pediatric hospitals.The hepatopathologic ¢ndings were classi¢ed in the samefashion as in a series of 61children with AIDSfrom North America (NA): in£ammation, nonspeci¢c, lymphoproliferative disorders, and giant cell transformation. By comparing both groups, we noted that the SA children were younger at time of death which was consistent with a more rapid progression of the disease. Opportunistic infections varied with a higher prevalence of cytomegalovirus (CMV) infection in SA children.The histopathologic features of CMV in the livers of SA children were associated with a conspicuous in£ammation absent in the NA group. F|nally, di¡erent nonspeci¢c hepatic changes were found in SA children, including one case of peliosis hepatis.

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“…To the best of our knowledge, the available literature reports do not describe more than three or four different opportunistic infections in vertically-infected children, even when considering the pre-HAART era 3± 8 , developing countries with limited pharmacological resources 3,9 , and endstage disease with diffuse visceralization 1,2,10 , and also necropsy ® ndings 10 . In particular, paediatric neurotoxoplasmosis is proportionally more rare 4,6,10 , and its cured relapses seem to be an exceptional event.…”

Section: Discussionmentioning

confidence: 97%

Multiple opportunistic AIDS-associated disorders strictly related to immunodeficiency levels, in a girl with congenital HIV infection

2003

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A 16-year-old girl with vertical HIV disease treated since birth suffered from six different AIDS-de® ning disorders until now. Even during the highly active antiretroviral therapy, multiple AIDS-related opportunistic infections may complicate the course of long-term congenital HIV disease, showing a strict relationship with immunological deterioration, which occurs shortly after virologic failure, due to an extensive genotypic resistance to all available antiretroviral compounds.

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OPPORTUNISTIC INFECTIONS IN PEDIATRIC HIV INFECTION: A study of 74 Autopsy Cases from Latin America

Cited by 22 publications

References 4 publications

Liver Pathology in Children With Aids: A Comparison Between the South American and North American Population

Liver Pathology in Children With Aids: A Comparison Between the South American and North American Population

Liver Pathology in Children With Aids: A Comparison Between the South American and North American Population

Multiple opportunistic AIDS-associated disorders strictly related to immunodeficiency levels, in a girl with congenital HIV infection

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