Opportunistic salpingectomy for prevention of sporadic ovarian cancer — a jump from basic science to clinical practice?

Zietek, Alicja; Bogusiewicz, Michał; Szumiło, Justyna; Rechberger, Tomasz

doi:10.5603/gp.2016.0027

Cited by 7 publications

(6 citation statements)

References 33 publications

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“…The presumed precursor tubal lesion, localized at the fimbrial end of the fallopian tubes, is termed the serous tubal intraepithelial carcinoma. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

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Prophylactic salpingectomy and ovarian cancer: An evidence-based analysis

Anggraeni

Fattah

Surya

2018

South Asian J Cancer

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Introduction:One of the ovarian carcinogenesis theories was the presence of premalignant cells in the epithelium of the fallopian tube. Therefore, the prophylactic salpingectomy during benign gynecological surgery is now expected as the attempt to reduce the ovarian cancer incidence. We studied the effect of prophylactic bilateral salpingectomy (PBS) in reducing the ovarian cancer incidence.Methods:This evidence-based report resulted from critical appraisal of 5 articles. It is aimed to answer our clinical question, can bilateral prophylactic salpingectomy reduce the incidence of ovarian cancer among women underwent hysterectomy for benign condition or permanent contraception surgery? The search was conducted on the Cochrane Library®, PubMed®, and Embase® using keywords of “prophylactic salpingectomy,” and “ovarian cancer incidence.” Reference lists of relevant articles were searched for other possibly relevant articles.Results:Five studies were included in our appraisal. The incidence of ovarian cancer among women underwent prophylactic salpingectomy is lower compared to women who were not underwent any intervention (2.2% to 13% and 4.75% to 24.4%). The salpingectomy may reduce 29.2% to 64% of ovarian cancer incidence. No significant effect of PBS to ovarian function, quality of life, sexuality, surgery duration, and its cost-effective profile were also found throughout our literature study.Conclusion:PBS is suggested to be performed for women during benign gynecological surgery as a primary preventive strategy of ovarian cancer. PBS is a cost-effective procedure, risk-reducing for ovarian cancer and has no significant effect to the ovarian function.

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“…The presumed precursor tubal lesion, localized at the fimbrial end of the fallopian tubes, is termed the serous tubal intraepithelial carcinoma. [ 8 ]…”

Section: Discussionmentioning

confidence: 99%

“…[ 7 ] Other gynecological boards already declared the beneficial impact of PBS, however, no clear statement that PBS should be performed. [ 8 ] This critical review aims to study the risk-reducing potencies of PBS for ovarian cancer.…”

Section: Introductionmentioning

confidence: 99%

Prophylactic salpingectomy and ovarian cancer: An evidence-based analysis

Anggraeni

Fattah

Surya

2018

South Asian J Cancer

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“…More than 70% cases of patients with ovarian cancer are diagnosed in an advanced stage (FIGO stage III or IV) owing to nonspecific symptoms in the early stage and because of the lack of effective screening methods 2 . The mortality rate among EOC patients remains high and the 5-year overall survival (OS) is only 20%–40% for advanced disease, although some progress has been achieved in EOC treatment 3 . …”

Section: Introductionmentioning

confidence: 99%

LncRNA PVT1 promotes ovarian cancer progression by silencing miR-214

Chen

Bao

et al. 2018

Cancer Biology & Medicine

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Objective:Emerging evidence indicates that long non-coding RNAs (lncRNAs) are critical in carcinogenesis and progression of ovarian cancer. This study aimed to explore the functions and molecular mechanisms of plasmacytoma variant translocation I (PVT1) in ovarian cancerMethods:PVT1 and miR-214 were detected by qRT-PCR assays in ovarian cancer tissues and cells. The cell proliferation, migration, and invasion abilities were detected by cell functional experiments, respectively. Western blot assay was performed to detect epithelial-mesenchymal transition (EMT) markers. MiR-214 expression regulated by PVT1 was studied by RNA immunoprecipitation (RIP) and chromatin immunoprecipitation (ChIP) assays.Results:The expression of PVT1 was up-regulated in ovarian cancer tissues and cell lines. Elevated PVT1 expression was associated with advanced stage and indicated poor prognosis for ovarian cancer patients. The knockdown of PVT1 impaired SKOV3 cell proliferation, migration, and invasion in vitro. The promotion of ovarian cancer progression by PVT1 involved in regulation of the epithelial-mesenchymal transition process and PVT1 interaction with EZH2 represses miR-214 expression in ovarian cancer cells. Conclusions:PVT1 plays an important role in ovarian cancer tumorigenesis, which might be as a novel diagnostic marker and therapeutic target for ovarian cancer.

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“…Nonspecific symptoms in early stage of disease and a lack of effective screening methods are the main reasons why more than 70% of cases are diagnosed in FIGO stage Ⅲ or Ⅳ 2 . Despite the progress in therapy the mortality rate remains high with a five-year overall of only 20-40% for advanced disease 3 . Studies reported that approximately 95% of ovarian cancers are of epithelial origin and the high-grade serous caner (HGSC) represents 75% of EOC and accounts for the majority of deaths 4 , 5 .…”

Section: Introductionmentioning

confidence: 99%

“…Thus, removal of the fallopian tubes at the time of pelvic or abdominal surgery for a benign condition (i.e. opportunistic salpingectomy) appeared as an attractive option for primary prevention of HGSC 3 , 11 .…”

Section: Introductionmentioning

confidence: 99%

Opportunistic salpingectomy at benign gynecological surgery for reducing ovarian cancer risk: a 10-year single centre experience from China and a literature review

Chen¹,

Bao

et al. 2018

J. Cancer

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Current evidences indicate that the fallopian tube plays a major role in the pathogenesis of epithelial ovarian cancer (EOC). Salpingectomy represents a novel and potentially effective risk-reducing option. In this study, there were 1822 patients diagnosed and treated for EOC or primary peritoneal cancer (PPC) at Department of Gynecologic Oncology, Tianjin Medical University Cancer Institute and Hospital from January 1, 2007 to April 30, 2017. Among them, 198 patients with a history of gynecological surgery because of benign diseases were enrolled to analyze further. Using 1:2 case-control study, we found that the incidence of EOC was significantly decreased in the population with salpingectomy, compared to women with fallopian tube reserved (P<0.05). At the same period, there were 4339 patients receiving opportunistic salpingectomy in our centre because of benign gynecological diseases. The results showed the rate of bilateral salpingectomy was annually increased from 2007 to 2017 (22.02% to 60.22%), which showed approximately threefold increase in a decade. In general, factors affecting the rate of salpingectomy included age, child number, menopause or not, marital status, educational status, income status, and with or without family history of tumor. Therefore, based on ten years experiences from our centre, it is recommended that physician should discuss with appropriate patients to perform opportunistic bilateral salpingectomy at the time of receiving benign gynecological surgery for preventing ovarian cancer. Moreover, the prospective, large scale and multi-centre studies to evaluate the safety and efficacy of salpingectomy as a preventive strategy for ovarian cancer warrant to conduct in the future.

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Opportunistic salpingectomy for prevention of sporadic ovarian cancer — a jump from basic science to clinical practice?

Cited by 7 publications

References 33 publications

Prophylactic salpingectomy and ovarian cancer: An evidence-based analysis

Prophylactic salpingectomy and ovarian cancer: An evidence-based analysis

LncRNA PVT1 promotes ovarian cancer progression by silencing miR-214

Opportunistic salpingectomy at benign gynecological surgery for reducing ovarian cancer risk: a 10-year single centre experience from China and a literature review

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