Opportunistic screening for colorectal neoplasia in Singapore using faecal immunochemical occult blood test

Alternatives to colonoscopy for population-wide colorectal cancer screening

“…Installation of sophisticated hardware is not required. Given a positivity rate of 5.5% to 11.0%, 12,13,17,19,28,29 however, it would have a significant impact on health care services. A major increase in the number of referrals for colonoscopy would be anticipated and thus require a corresponding increase in the availability of endoscopy centres and endoscopists.…”

“…18,28,30,31 The PPV ranges from 5.2% to 12.8% at a cut-off value of 75 ng/mL. 12,13,[17][18][19][28][29][30][31][32] The NNScreen and NNScope ranges from 213 to 936 and 12,13,17,19,[28][29][30]32 These results are summarised in Table 2. For advanced adenoma, the sensitivity and specificity ranges from 33.9% to 41.3% and 91.4% to 97.3%, respectively.…”

“…It requires no dietary restrictions 16 and has a participation rate of 38.9% to 71.9%. [17][18][19] The results can be qualitative or quantitative. 20 Sampling technique, distribution of blood in faeces, and sample instability make true quantification difficult, however.…”

“…27 The positivity rate of iFOBT ranges from 5.5% to 11.0%. 12,13,17,19,28,29 The sensitivity and specificity for CRC ranges from 53.3% to 94.1% and 87.5% to 96.9%, respectively. 18,28,30,31 The PPV ranges from 5.2% to 12.8% at a cut-off value of 75 ng/mL.…”

Opportunistic Colorectal Cancer Screening using Colonoscopy. Comparative Results between two Historical Cohorts in Bucharest, Romania

“…However, it may be an alternative when organized screening programs are not available. Colorectal cancer screening in Taiwan using the FIT test [18] and in Germany or Iran using colonoscopy [19,20] has been reported. Recently, it has been advocated in Romania, considering the lack of such an organized program [21].…”