Opportunities and Challenges in Biomedical Applications of Metal–Organic Frameworks

Salehipour, Masoud; Rezaei, Shahla; Rezaei, Mahsa; Yazdani, Mahsa; Mogharabi‐Manzari, Mehdi

doi:10.1007/s10904-021-02118-7

Cited by 47 publications

(20 citation statements)

References 171 publications

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“…Despite promising results suggesting minimal cytotoxicity and toxicity of MOFs, there are still limited in vivo toxicity studies on different MOF materials [ 191 , 194 ]. Even so, preliminary studies identified that parameters such as size, shape, functionalization, and solvent systems may influence MOFs biodistribution and toxicity, as well as the use of toxic metals in the composition, such as lead, arsenic, cadmium, and chromium, which may promote severe health issues [ 196 ]. Nevertheless, further comprehensive and in-depth research of the long-term impacts of MOFs and their combined therapies may be necessary to better determine their biosafety.…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

“…As a result, there is a need for novel or optimized functionalization methods that allow for the incorporation of a range of therapeutics to produce more suited and sophisticated MOFs for therapeutic applications. Moreover, the pharmacokinetics, degradation mechanisms, and toxicity of MOFs are still poorly understood, and further research is needed to develop and design novel MOF nanocomposites with higher stability, biocompatibility, and therapeutic performance [ 196 , 200 ]. Validation and standardization of testing procedures are also critical for the field's development [ 191 ].…”

Section: Challenges and Opportunitiesmentioning

confidence: 99%

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Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy

et al. 2023

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Conventional cancer therapies, such as radiotherapy and chemotherapy, can have long-term side effects. Phototherapy has significant potential as a non-invasive alternative treatment with excellent selectivity. Nevertheless, its applicability is restricted by the availability of effective photosensitizers and photothermal agents, and its low efficacy when it comes to avoiding metastasis and tumor recurrence. Immunotherapy can promote systemic antitumoral immune responses, acting against metastasis and recurrence; however, it lacks the selectivity displayed by phototherapy, sometimes leading to adverse immune events. The use of metal-organic frameworks (MOFs) in the biomedical field has grown significantly in recent years. Due to their distinct properties, including their porous structure, large surface area, and inherent photo-responsive properties, MOFs can be particularly useful in the fields of cancer phototherapy and immunotherapy. MOF nanoplatforms have successfully demonstrated their ability to address several drawbacks associated with cancer phototherapy and immunotherapy, enabling an effective and low-side-effect combinatorial synergistical treatment for cancer. In the coming years, new advancements in MOFs, particularly regarding the development of highly stable multi-function MOF nanocomposites, may revolutionize the field of oncology.

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Section: Challenges and Opportunitiesmentioning

confidence: 99%

Section: Challenges and Opportunitiesmentioning

confidence: 99%

Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy

et al. 2023

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“…Numerous techniques have been employed for illicit drug detection in forensic toxicology, such as nuclear magnetic resonance [ 4 , 5 ], mass spectrometry [ 6 , 7 ], combined gas chromatography/mass spectrometry (GC-MS) [ 8 , 9 ], high-performance liquid chromatography (HPLC) [ 10 ], and X-ray powder diffraction [ 11 ]. In spite of their high molecular specificity, the aforementioned methods are typically centralized and require extensive sample preparation, expensive reagents, trained personnel, and time-consuming analysis.…”

Section: Introductionmentioning

confidence: 99%

Recent Advances in the Use of Surface-Enhanced Raman Scattering for Illicit Drug Detection

Azimi¹,

Docoslis²

2022

Sensors

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The rapid increase in illicit drug use and its adverse health effects and socio-economic consequences have reached alarming proportions in recent years. Surface-enhanced Raman scattering (SERS) has emerged as a highly sensitive analytical tool for the detection of low dosages of drugs in liquid and solid samples. In the present article, we review the state-of-the-art use of SERS for chemical analysis of illicit drugs in aqueous and complex biological samples, including saliva, urine, and blood. We also include a review of the types of SERS substrates used for this purpose, pointing out recent advancements in substrate fabrication towards quantitative and qualitative detection of illicit drugs. Finally, we conclude by providing our perspective on the field of SERS-based drug detection, including presently faced challenges. Overall, our review provides evidence of the strong potential of SERS to establish itself as both a laboratory and in situ analytical method for fast and sensitive drug detection and identification.

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“…Nanotechnology has allowed advances in monitoring, diagnosis, prognosis, and proposing effective treatments [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 ]. In this sense, biosensors based on nanomaterials have accurate detection, efficient monitoring, and fast but reliable imaging [ 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

Two-Dimensional Graphitic Carbon Nitride (g-C3N4) Nanosheets and Their Derivatives for Diagnosis and Detection Applications

Pourmadadi

Rajabzadeh‐Khosroshahi

Tabar

et al. 2022

JFB

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The early diagnosis of certain fatal diseases is vital for preventing severe consequences and contributes to a more effective treatment. Despite numerous conventional methods to realize this goal, employing nanobiosensors is a novel approach that provides a fast and precise detection. Recently, nanomaterials have been widely applied as biosensors with distinctive features. Graphite phase carbon nitride (g-C3N4) is a two-dimensional (2D) carbon-based nanostructure that has received attention in biosensing. Biocompatibility, biodegradability, semiconductivity, high photoluminescence yield, low-cost synthesis, easy production process, antimicrobial activity, and high stability are prominent properties that have rendered g-C3N4 a promising candidate to be used in electrochemical, optical, and other kinds of biosensors. This review presents the g-C3N4 unique features, synthesis methods, and g-C3N4-based nanomaterials. In addition, recent relevant studies on using g-C3N4 in biosensors in regard to improving treatment pathways are reviewed.

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Opportunities and Challenges in Biomedical Applications of Metal–Organic Frameworks

Cited by 47 publications

References 171 publications

Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy

Metal-Organic Frameworks Applications in Synergistic Cancer Photo-Immunotherapy

Recent Advances in the Use of Surface-Enhanced Raman Scattering for Illicit Drug Detection

Two-Dimensional Graphitic Carbon Nitride (g-C3N4) Nanosheets and Their Derivatives for Diagnosis and Detection Applications

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