Opportunities and challenges of microneedle electrochemical sensors for interstitial fluid detection

Dong, Yanming; Mao, Siying; Chen, Shiwei; Ma, Junhua; Jaffrezic-Renault, Nicole; Guo, Zhenzhong

doi:10.1016/j.trac.2024.117891

TrAC Trends in Analytical Chemistry

2024

DOI: 10.1016/j.trac.2024.117891

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Opportunities and challenges of microneedle electrochemical sensors for interstitial fluid detection

Yanming Dong,

Siying Mao,

Shiwei Chen

et al.

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Cited by 3 publications

References 106 publications

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Recent progress in the 3D printing of microneedle patches for biomedical applications

Liu,

Nail,

Meng

et al. 2025

International Journal of Pharmaceutics

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Recent progress in the 3D printing of microneedle patches for biomedical applications

Liu,

Nail,

Meng

et al. 2025

International Journal of Pharmaceutics

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Microneedle Electrode Patch Modified with Graphene Oxide and Carbon Nanotubes for Continuous Uric Acid Monitoring and Diet Management in Hyperuricemia

Zhao,

Zhu,

et al. 2024

ACS Appl. Bio Mater.

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Hyperuricemia is a common disorder induced by purine metabolic abnormality, which will further cause chronic kidney disease, cardiovascular disease, and gout. Its main pathological characteristic is the high uric acid (UA) level in the blood, so that the detection of UA is highly important for hyperuricemia diagnosis and therapy. Herein, we report a biocompatible and minimally invasive microneedle electrode patch (MEP) for continuous UA monitoring and diet management in hyperuricemia. The composite of graphene oxide and carboxylated multiwalled carbon nanotubes was modified on the microneedle electrode surface to enhance its sensitivity, selectivity, and stability, thus realizing the continuous detection of UA in the interstitial fluid to accurately predict the UA level in the blood. This further allowed us to study the hypouricemic effect of anthocyanins on the hyperuricemia model mouse. It was found that anthocyanins extracted from blueberry can effectively inhibit the activity of xanthine oxidase to reduce the production of UA. The UA level of hyperuricemia model mice fed with anthocyanins is ∼1.7 fold lower than that of the control group. We believe that this MEP offers enormous promise for continuous UA monitoring and diet management in hyperuricemia.

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3D-Printed Electrochemical Sensors: A Comprehensive Review of Clinical Analysis Applications

Cândido,

Silva,

Borges

et al. 2024

Analytica

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Three-dimensional printing technology has emerged as a versatile and cost-effective alternative for the fabrication of electrochemical sensors. To enhance sensor sensitivity and biocompatibility, a diverse range of biocompatible and conductive materials can be employed in these devices. This allows these sensors to be modified to detect a wide range of analytes in various fields. 3D-printed electrochemical sensors have the potential to play a pivotal role in personalized medicine by enabling the real-time monitoring of metabolite and biomarker levels. These data can be used to personalize treatment strategies and optimize patient outcomes. The portability and low-cost nature of 3D-printed electrochemical sensors make them suitable for point-of-care (POC) diagnostics. These tests enable rapid and decentralized analyses, aiding in diagnosis and treatment decisions in resource-limited settings. Among the techniques widely reported in the literature for 3D printing, the fused deposition modeling (FDM) technique is the most commonly used for the development of electrochemical devices due to the easy accessibility of equipment and materials. Focusing on the FDM technique, this review explores the critical factors influencing the fabrication of electrochemical sensors and discusses potential applications in clinical analysis, while acknowledging the challenges that need to be overcome for its effective adoption.

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Opportunities and challenges of microneedle electrochemical sensors for interstitial fluid detection

Cited by 3 publications

References 106 publications

Recent progress in the 3D printing of microneedle patches for biomedical applications

Recent progress in the 3D printing of microneedle patches for biomedical applications

Microneedle Electrode Patch Modified with Graphene Oxide and Carbon Nanotubes for Continuous Uric Acid Monitoring and Diet Management in Hyperuricemia

3D-Printed Electrochemical Sensors: A Comprehensive Review of Clinical Analysis Applications

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