Opportunities and limits of commercial farm data to study the genetic determinism of feed efficiency throughout lactation in dairy sheep

Machefert, C.; Robert-Granié, C.; Lagriffoul, G.; Parisot, S.; Allain, C.; Portes, D.; Astruc, J.M; Hassoun, P.; Larroque, H.

doi:10.1016/j.animal.2023.100951

animal

2023

DOI: 10.1016/j.animal.2023.100951

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Opportunities and limits of commercial farm data to study the genetic determinism of feed efficiency throughout lactation in dairy sheep

C. Machefert,

C. Robert-Granié,

G. Lagriffoul

et al.

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Cited by 2 publications

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“…The genetic study of sheep resilience has so far involved diverse traits regarding resistance to disease, resilience to weather conditions, longevity and resource use efficiency (Sánchez-Molano et al, 2020;Tsartsianidou et al, 2021;Hine et al, 2022;Mucha et al, 2022;Machefert et al, 2023). In dairy sheep, resilience is mainly associated with good udder health combined with longevity, extended lactations and adequately high milk performance.…”

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“…Under similar nutritional management, energy balance and body fat reserves are expected to be relatively uniform among individuals of the same breed and production level; hence, deviation from an optimum BCS is an indicator of inefficient use of resources and poor resilience to environmental stressors. Although BCS is a trait of moderate heritability with improvement potential, relevant research data on dairy sheep are very limited (Machefert et al, 2023).…”

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A genome-wide association study reveals novel SNP markers associated with resilience traits in two Mediterranean dairy sheep breeds

Argyriadou,

Michailidou,

Vouraki

et al. 2023

Front. Genet.

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Genetic selection for higher productivity increased dairy sheep susceptibility to diseases and environmental stressors, challenging their health and welfare status and production efficiency. Improving resilience to such stressors can enhance their ability to face these challenges without compromising productivity. Our objective was to estimate genomic heritability and perform genome-wide association studies (GWAS) to detect SNPs and candidate genes associated with three proxy traits for resilience (milk somatic cell count—SCC, lactation persistency—LP, body condition score—BCS) of Chios and Frizarta dairy ewes. We used genome-wide genotypes of 317 Chios and 346 Frizarta ewes. Individual records of milk yield and BCS, and milk samples were collected monthly for two consecutive milking periods; samples were analyzed to determine SCC. The LP was calculated as the regression coefficient of daily milk yield on days from lambing. Within breed, variance components analyses and GWAS were performed using genomic relatedness matrices in single-trait animal linear mixed models. Genomic-based heritability estimates were relatively high (BCS: h2 = 0.54 and 0.55, SCC: h2 = 0.25 and 0.38, LP: h2 = 0.43 and 0.45, for Chios and Frizarta ewes, respectively), compared to previous pedigree-based studies. The GWAS revealed 7 novel SNPs associated with the studied traits; one genome-wide and two suggestive significant SNPs for SCC (Frizarta: rs403061409, rs424064526 and rs428540973, on chromosomes 9, 1 and 12, respectively), one suggestive significant SNP for BCS (Chios: rs424834097 on chromosome 4) and three suggestive significant SNPs for LP (Frizarta: rs193632931 and rs412648955 on chromosomes 1 and 6, Chios: rs428128299 on chromosome 3). Nineteen candidate genes were detected: two for BCS (Chios: POT1, TMEM229A), thirteen for SCC (Frizarta: NTAQ1, ZHX1, ZHX2, LOC101109545, HAS2, DERL1, FAM83A, ATAD2, RBP7, FSTL1, CD80, HCLS1, GSK3B) and four for LP (Frizarta: GRID2, FAIM, CEP70—Chios: GRIP1). Present results show that resilience in the studied dairy sheep breeds is heritable and advance existing knowledge on the genomic background of SCC, LP, and BCS. Future research will quantify effects of different alleles of significant SNPs on the studied traits and search for possible correlations among traits to facilitate their effective incorporation in breeding programs aiming to improve resilience.

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confidence: 99%

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confidence: 99%

A genome-wide association study reveals novel SNP markers associated with resilience traits in two Mediterranean dairy sheep breeds

Argyriadou,

Michailidou,

Vouraki

et al. 2023

Front. Genet.

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Genetic parameters of milk mid-infrared spectra and their genetic relationships with milk production and feed efficiency traits in French Lacaune dairy sheep

Machefert,

Robert-Granié,

Astruc

et al. 2024

Journal of Dairy Science

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Opportunities and limits of commercial farm data to study the genetic determinism of feed efficiency throughout lactation in dairy sheep

Cited by 2 publications

References 29 publications

A genome-wide association study reveals novel SNP markers associated with resilience traits in two Mediterranean dairy sheep breeds

A genome-wide association study reveals novel SNP markers associated with resilience traits in two Mediterranean dairy sheep breeds

Genetic parameters of milk mid-infrared spectra and their genetic relationships with milk production and feed efficiency traits in French Lacaune dairy sheep

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