Opportunities and short-comings of the axolotl salamander heart as a model system of human single ventricle and excessive trabeculation

Lauridsen, Henrik; Pedersen, Kathrine; Andersson, Sofie Amalie; Ooij, Pim van; Willems, Tineke P.; Berger, Rolf M. F.; Ebels, Tjark; Jensen, Bjarke

doi:10.1038/s41598-022-24442-9

Cited by 5 publications

(3 citation statements)

References 46 publications

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“…Previous studies exhibit an average weight of 131.12 gr, 39.2 ± 25.2 gr and body length 24.6 cm, 17.2 ± 4.5 cm respectively. 32,33 Our population was closed to these data for measurement however weights were slightly higher.…”

Section: Discussionmentioning

confidence: 99%

“…In comparison, resting conscious heart rate shows 21.7 ± 4.1 BPM using eulerian video magni cation, which is lower than our data. 33 However, eulerian video magni cation allows to obtain data without manipulation. Another study describes a mean heart rate at of 22.23 ± 5.18 BPM at rest and a mean heart rate of 39.44 ± 2.38 BPM during exercise, the latter correlate with our data.…”

Section: Discussionmentioning

confidence: 99%

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Ultrasound description of the coelomic cavity of the axolotl (Ambystoma mexicanum) in a healthy population: a pilot study

Vieu,

Poul,

Tur

et al. 2023

Preprint

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Axolotls (Ambystoma mexicanum) are widely studied for human medical research. While critically endangered in wildlife, they have also become popular as household pets. Although they have been kept in captivity for over a century, coelomic organs description of their anatomy remains limited, and this species presents significant variations compared to other amphibians. Ultrasound is a non-invasive, painless medical imaging technique, well-suited for investigating internal organs or other structures. This study describes ultrasound appearance of the axolotl coelomic cavity. Identification, localization and parenchyma description of major organs are reported on 28 neotenic axolotls by using frequencies between 7 to 15 MHz. Results were confirmed by comparing ultrasound and necropsy on one male and one female. The heart, lung surface, liver and reproductive tracts were observed. Measurements with confidence intervals were calculated for spleen, kidneys, testicles, gastric wall, gallbladder, and pylorus. Hyperechoic millimetric particles in gallbladder or ascites were occasionally detected. Pancreas and bladder could not be observed. The outcomes of this research include the production of images combined in an atlas. The experiment showed a repeatable and easily accessible protocol for anatomy-morphological assessment in axolotl medicine and is the necessary step before identification of lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Ultrasound description of the coelomic cavity of the axolotl (Ambystoma mexicanum) in a healthy population: a pilot study

Vieu,

Poul,

Tur

et al. 2023

Preprint

View full text Add to dashboard Cite

show abstract

“…The trabeculae, forming deep sacs, gather and retain blood during diastolic filling. This mechanism appears to enable a partial separation of the blood not only during this final phase but also while the blood is being expelled during systole [26][27][28]. There are also exceptions, such as tadpoles and some adult salamanders, which have pulmonocutaneous circulation.…”

mentioning

confidence: 99%

Cardiovascular Response to Exercise in Vertebrates: Update

López-Román,

Gómez-Lucas,

Jiménez-Herranz

et al. 2024

Preprint

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Physical exercise is the greatest stress on the cardiovascular system, not only in humans but also in all vertebrates. Consequently, the cardiovascular response cannot be thought of as having only one "anthropocentric" interpretation. The modulation of cardiac output (Q) in response to exercise in the five major groups of vertebrates exhibits considerable variability. Moreover, the response of the heart rate (HR) and the stroke volume (SV), the fundamental factors that cause the rise in Q, is also highly variable. The difference in the range of HR is difficult to determine in many vertebrates, both at rest and at maximal effort. Additionally, the increase in SV varies among vertebrates. For example, while rainbow trout and leopards increase their SV by increasing end diastolic volume (EDV), humans do so at the expense of both increasing EDV and reducing end systolic volume (ESV). The variation in arterial pressure that arises during exercise varies notably among vertebrates, such as amphibians, whose blood pressure values do not increase as significantly as in mammals. Such differences in cardiovascular response among vertebrates may be linked to their habitat or living environment. This review aims to analyze the cardiovascular response of vertebrates to physical exercise as the most common stressor.

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Ultrasound description of the coelomic cavity of the axolotl (Ambystoma mexicanum) in a clinically healthy population: a pilot study

Vieu,

Le Poul,

Tur

et al. 2024

Sci Rep

View full text Add to dashboard Cite

Axolotls (Ambystoma mexicanum) are extensively studied for their relevance in human medical research. Despite being critically endangered in the wild, they have gained popularity as household pets. Although they have been kept in captivity for over a century, detailed descriptions of their coelomic organ anatomy remain limited. Also, this species exhibits significant variations compared to other amphibians. Ultrasound is a non-invasive and painless medical imaging technique, ideally suited for investigating internal organs or structures. This study focused on describing the ultrasound appearance of the axolotl coelomic cavity. It details the identification, localization and parenchymal description of major organs in 28 neotenic axolotls using ultrasound frequencies ranging from 7 to 15 MHz. The accuracy of the results was validated by comparing ultrasound findings with necropsy results from one male and one female axolotl. The heart, lung surface, liver and reproductive tracts were visualized. Measurements, along with confidence intervals, were calculated for the spleen, kidneys, testicles, gastric wall, gallbladder, and pylorus. Occasional detection of hyperechoic millimetric particles in the gallbladder or ascites was noted. However, visualization of the pancreas and bladder was not possible. This research outcomes involve the development of a comprehensive atlas comprising images obtained throughout the study. Additionally, the experiment established a reproducible and readily accessible protocol for conducting anatomy-morphological assessments in axolotl medicine. This protocol stands as a crucial preliminary stage before advancing to lesion identification.

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Opportunities and short-comings of the axolotl salamander heart as a model system of human single ventricle and excessive trabeculation

Cited by 5 publications

References 46 publications

Ultrasound description of the coelomic cavity of the axolotl (Ambystoma mexicanum) in a healthy population: a pilot study

Ultrasound description of the coelomic cavity of the axolotl (Ambystoma mexicanum) in a healthy population: a pilot study

Cardiovascular Response to Exercise in Vertebrates: Update

Ultrasound description of the coelomic cavity of the axolotl (Ambystoma mexicanum) in a clinically healthy population: a pilot study

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