2018
DOI: 10.1016/j.mib.2018.08.004
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Opportunities for plant natural products in infection control

Abstract: The continued spread of antimicrobial resistance represents one of the most serious infectious disease threats to global health. There is consensus that a key component of addressing this threat is to replenish the waning pipeline of antimicrobials, with attention being paid to novel mechanisms of action. This includes the development of new classes of classic bacteriostatic and bactericidal antibiotics as well as antivirulence drugs, and it is especially in these areas where plant natural products demonstrate… Show more

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Cited by 60 publications
(43 citation statements)
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References 48 publications
(55 reference statements)
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“…The activity of a range of natural products against microbes in simple in vitro assays (agar diffusion, broth microdilution or simple surface-attached biofilm assays) demonstrates their potential as a source of novel antibiotics 29 31 . However, the standard approach of purifying individual compounds from natural products rarely produces clinically useful products, and potent activity against planktonic bacteria in standard lab media rarely translates to in vivo efficacy.…”
Section: Discussionmentioning
confidence: 99%
“…The activity of a range of natural products against microbes in simple in vitro assays (agar diffusion, broth microdilution or simple surface-attached biofilm assays) demonstrates their potential as a source of novel antibiotics 29 31 . However, the standard approach of purifying individual compounds from natural products rarely produces clinically useful products, and potent activity against planktonic bacteria in standard lab media rarely translates to in vivo efficacy.…”
Section: Discussionmentioning
confidence: 99%
“…The activity of a range of natural products against microbes in simple in vitro assays (agar diffusion, broth microdilution or simple surface-attached biofilm assays) demonstrates their potential as a source of novel antibiotics (3537). However, the standard approach of purifying individual compounds from natural products rarely produces clinically useful products and potent activity against planktonic bacteria in standard lab media rarely translates to in vivo efficacy.…”
Section: Discussionmentioning
confidence: 99%
“…Instead of using antibiotics, biological antimicrobial agents including natural products and bacteriocins can be used to control bacterial contamination [88]. Natural antimicrobial compounds are derived from different natural sources such as animals, plants, and microorganisms, and have been used for the treatment of human infections as well as the prevention of food spoilage [89][90][91]. One of the traditional examples is the addition of hops to the brewing process [92].…”
Section: Natural Antimicrobial Compounds and Bacteriocinsmentioning
confidence: 99%