Opportunities to leverage reproductive goals and ideals among South African men to promote HIV testing, treatment and prevention: A qualitative study

Isehunwa, Oluwaseyi O.; Ntinga, Xolani; Msimango, Lindani; Smith, Patricia M.; Heerden, Alastair van; Matthews, Lynn T.

doi:10.1080/17441692.2023.2173795

Cited by 2 publications

(2 citation statements)

References 45 publications

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“…Educating men about HIV-prevention options for their pregnancy partners may also support uptake [61]. Reassuringly, genotyping of the virus among those with seroconversion revealed mutations that are not associated with exposure to NRTIs (e.g., tenofovir, emtricitabine) and thus are likely to represent transmitted resistance [62].…”

Section: Discussionmentioning

confidence: 99%

“…Interventions to promote knowledge of partner serostatus remain important, but should not undermine opportunities to provide PrEP to women who may not know their partner's serostatus but live in an HIV-endemic area or otherwise feel vulnerable to HIV [ 48 ]. Educating men about HIV-prevention options for their pregnancy partners may also support uptake [ 61 ]. Reassuringly, genotyping of the virus among those with seroconversion revealed mutations that are not associated with exposure to NRTIs (e.g., tenofovir, emtricitabine) and thus are likely to represent transmitted resistance [ 62 ].…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Oral preexposure prophylaxis uptake, adherence, and persistence during periconception periods among women in South Africa

Matthews,

Jaggernath,

Kriel

et al. 2024

Aids

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Objective: We developed the Healthy Families-PrEP intervention to support HIV-prevention during periconception and pregnancy. We evaluated preexposure prophylaxis (PrEP) use with three objective measures. Design: This single-arm intervention study enrolled women in KwaZulu-Natal, South Africa, who were HIV-uninfected, not pregnant, in a relationship with a partner with HIV or unknown-serostatus, and with pregnancy plans. PrEP was offered as part of a comprehensive HIV prevention intervention. Participants were followed for 12#$##x0200A;months. Methods: We evaluated periconception PrEP uptake and adherence using quarterly plasma tenofovir concentrations. We modeled factors associated with PrEP uptake and high plasma tenofovir (past day dosing). Patterns of use were analyzed using electronic pillcap data. Dried blood spots to measure intracellular tenofovir product (past 2#$##x0200A;months dosing) were analyzed for a subset of women. Results: Three hundred thirty women with median age 24 (IQR: 22#$#ndash;27) years enrolled. Partner HIV-serostatus was unknown by 96% (N#$##x0200A;#$#equals;#$##x0200A;316); 60% (195) initiated PrEP. High plasma tenofovir concentrations were seen in 35, 25, 22, and 20% of samples at 3, 6, 9, and 12#$##x0200A;months, respectively. Similar adherence was measured by pillcap and dried blood spots. In adjusted models, lower income, alcohol use, and higher HIV stigma were associated with high plasma tenofovir. Eleven HIV-seroconversions were observed (incidence rate: 4.04/100 person-years [95% confidence interval: 2.24#$#ndash;7.30]). None had detectable plasma tenofovir. Conclusion: The Healthy Families-PrEP intervention supported women in PrEP use. We observed high interest in periconception PrEP and over one-third adhered to PrEP in the first quarter; one-fifth were adherent over a year. High HIV incidence highlights the importance of strategies to reduce HIV incidence among periconception women. Clinical Trial Number: NCT03194308

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Oral preexposure prophylaxis uptake, adherence, and persistence during periconception periods among women in South Africa

Matthews,

Jaggernath,

Kriel

et al. 2024

Aids

View full text Add to dashboard Cite

show abstract

Uptake and Persistence of Safer Conception Strategies Among South African Women Planning for Pregnancy

Isehunwa,

Jaggernath,

Kriel

et al. 2024

AIDS Behav

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Safer conception strategies can minimize HIV acquisition during periconception periods among women living in HIV-endemic areas. We examined uptake and predictors of persistent use of the same safer conception strategy among a cohort of HIV-uninfected South African women ages 18–35 years planning for pregnancy with a partner living with HIV or of unknown HIV-serostatus. The safer conception strategies we evaluated included oral PrEP, condomless sex limited to peak fertility, and waiting for a better time to have a child (until, for example, the risks of HIV acquisition are reduced and/or the individual is prepared to care for a child); persistence was defined as using the same safer conception strategy from the first visit through 9 months follow-up. Modified Poisson regression models were used to examine predictors of persistent use of the same strategy. The average age of 227 women in our cohort was 24.6 (range: 18.0, 35.7) years. In this cohort, 121 (74.2%) women reported persisting in the same strategy through 9 months. Employment and HIV knowledge were associated with the persistent use of any strategy. Our results highlight the need to provide safer conception services to women exposed to HIV during periconception periods. Findings also offer some insights into factors that might influence persistent use. Further research is needed to better understand how to involve male partners and how their involvement might influence women’s consistent use of safer conception strategies during periconception periods.

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Opportunities to leverage reproductive goals and ideals among South African men to promote HIV testing, treatment and prevention: A qualitative study

Cited by 2 publications

References 45 publications

Oral preexposure prophylaxis uptake, adherence, and persistence during periconception periods among women in South Africa

Oral preexposure prophylaxis uptake, adherence, and persistence during periconception periods among women in South Africa

Uptake and Persistence of Safer Conception Strategies Among South African Women Planning for Pregnancy

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