Opportunity in nanomedicine to counter the challenges of current drug delivery approaches used for the treatment of malaria: a review

Rajwar, Tushar Kanti; Pradhan, Deepak; Halder, Jitu; Kumar, Vineet; Kar, Biswakanth; Ghosh, Goutam; Rath, Goutam

doi:10.1080/1061186x.2022.2164290

Cited by 15 publications

(5 citation statements)

References 78 publications

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“…A key advantage of nanostructured drug delivery systems is their ability to modulate the pharmacokinetic profile of AMBQ, thereby enhancing its therapeutic efficacy while minimizing systemic side effects [14] . By encapsulating AMBQ within nanocarriers, researchers can exert fine control over parameters such as drug release kinetics, solubility, and stability, optimizing its bioavailability and therapeutic index [15][16][17][18][19] . This level of control enables the development of AMBQ formulations tailored to specific routes of administration, patient populations, and disease states, fostering personalized medicine approaches that optimize treatment outcomes [20] .…”

Section: Key Considerations In the Development Of Nanostructured Carr...mentioning

confidence: 99%

Nanostructured carrier systems facilitating enhanced delivery of 8-(4-Amino-1 methylbutylamino)-6 methoxyquinoline: a narrative review

Abbas

2024

International Journal of Surgery: Global Health

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8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline, an inhibitor of protozoan growth, presents an opportunity to explore nanostructured drug carriers to overcome these challenges. By encapsulating this compound in nanocarriers such as liposomes, dendrimers or polymeric nanoparticles, you can improve its solubility and protect it from degradation, thereby increasing circulation time and accumulation at the target site. This review will explore various nanostructured carriers for 8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline, analyze their properties, and discuss how nanotechnology can enhance the efficacy of this antiparasitic agent. With the prevalence of parasitic diseases around the globe nanomedicine may provide the solution by enabling more effective delivery of compounds like 8-(4-Amino-1-methylbutylamino)-6-methoxyquinoline.

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Section: Key Considerations In the Development Of Nanostructured Carr...mentioning

confidence: 99%

Nanostructured carrier systems facilitating enhanced delivery of 8-(4-Amino-1 methylbutylamino)-6 methoxyquinoline: a narrative review

Abbas

2024

International Journal of Surgery: Global Health

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“…5−7 In order to solve these problems, new types of antimalaria APIs and various derivatives of artemisinin, like artesunate (ART) and dihydroartemisinin (DHA), were developed; 8−10 a series of finely designed nanovesicles have been proposed to efficiently deliver artemisinin as well as its derivatives. 11,12 For instance, Gao et al proposed a self-emulsifying drug delivery system (SEDDS), which displayed higher solubility, permeability, and bioactivity. 4 Since artemisinin is of low molecular weight and displays obvious hydrophobicity (log P = 2), transdermal delivery may be an efficient way, which shows a lot of merits that can promote the bioavailability and convenience.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Although artemisinin did show good therapeutic effects, it has some drawbacks such as low solubility (the solubility in water was as low as 0.059 mg/mL), poor bioavailability (approximately 30%), and short half-life time (2–3 h). − In order to solve these problems, new types of antimalaria APIs and various derivatives of artemisinin, like artesunate (ART) and dihydroartemisinin (DHA), were developed; − a series of finely designed nanovesicles have been proposed to efficiently deliver artemisinin as well as its derivatives. , For instance, Gao et al proposed a self-emulsifying drug delivery system (SEDDS), which displayed higher solubility, permeability, and bioactivity . Since artemisinin is of low molecular weight and displays obvious hydrophobicity (log P = 2), transdermal delivery may be an efficient way, which shows a lot of merits that can promote the bioavailability and convenience. , However, only a few research studies concerning the transdermal delivery of artemisinin have been reported, where solid dispersions, microemulsions, solid lipid nanoparticles (SLNs), niosomes, etc.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Deep Eutectic Solvent-Based Microemulsion for Transdermal Delivery of Artemisinin

Li,

Yuan,

Liu

et al. 2024

Langmuir

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As a serious public health issue, malaria threatens the health of millions of people. Artemisinin, a gift from traditional Chinese medicine, has been used in the treatment of malaria and has shown good therapeutic efficiency. However, due to its low solubility, poor bioavailability, and short half-life time, some smart delivery strategies are still required. Herein, a multifunctional DES prepared from ibuprofen and menthol was prepared. This DES was shown to efficiently promote the solubility of artemisinin up to 400-fold. Then, it was further applied as the oil phase to construct an O/W microemulsion with the help of Tween-80 + Span-20 mixed surfactants. The prepared microemulsion displayed high efficiency in improving the permeability of artemisinin, which can be ascribed to the presence of the permeation enhancer menthol in DES and the microstructure of the O/W microemulsion. Moreover, the simultaneous permeation of artemisinin and ibuprofen further indicated the potential benefits of the presented formulation in the treatment of malaria. To sum up, the microemulsion based on multifunctional DES presented herein provided an effective method for transdermal delivery of artemisinin.

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“…Furthermore, other studies have been directed toward the field of nanotechnology to resolve the challenges of the conventional antimalarial dosage form such as poor water solubility, short half-life, low bioavailability, multiple drug dose, and high drug-related toxicity. Nanocarriers can play an essential role in the case management of malaria by altering the pharmacokinetics and pharmacodynamics of drugs [ 29 ]. In this respect, several ART-based drug delivery systems have been investigated, such as implants [ 30 ], liposomes, polymeric nanoparticles, lipid-based nanoparticles, metal-based nanoparticles, hybrid drugs, and nanoemulsion (NE) [ 31 ].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Characterization of Dimeric Artesunate Glycerol Monocaprylate Conjugate and Formulation of Nanoemulsion Preconcentrate

et al. 2023

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Malaria is one of the major life-threatening health problems worldwide. Artesunate is the most potent antimalarial drug to combat severe malaria. However, development of drug resistance, short plasma half-life, and poor bioavailability limit the efficacy of this drug. Here, we applied the dimerization concept to synthesize dimeric artesunate glycerol monocaprylate conjugate (D-AS-GC) by conjugating artesunate (AS) with glycerol monocaprylate (GC) via esterification reaction. D-AS-GC conjugate, AS, and GC were well characterized by 1H NMR, attached proton test (APT) 13C NMR and 2D NMR spectroscopy. D-AS-GC conjugate was further analyzed by ESI-TOF MS. Finally, a series of nanoemulsion preconcentrate (F1–F6) of D-AS-GC was prepared by mixing different ratios of oil and surfactant/cosurfactant and evaluated after dilution with an aqueous phase. The optimized formulation (F6) exhibits a clear nanoemulsion and the hydrodynamic diameter of the dispersed phase was determined by DLS and DOSY NMR spectroscopy. The morphology of the nanoemulsion droplets of F6 was investigated by AFM, which revealed the formation of tiny nanoemulsion droplets on a hydrophilic mica substrate. Moreover, using a less polar silicon wafer led to the formation of larger droplets with a spherical core shell-like structure. Overall, the rational design of the dimeric artesunate-based nanoemulsion preconcentrate could potentially be used in more efficient drug delivery systems.

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Opportunity in nanomedicine to counter the challenges of current drug delivery approaches used for the treatment of malaria: a review

Cited by 15 publications

References 78 publications

Nanostructured carrier systems facilitating enhanced delivery of 8-(4-Amino-1 methylbutylamino)-6 methoxyquinoline: a narrative review

Nanostructured carrier systems facilitating enhanced delivery of 8-(4-Amino-1 methylbutylamino)-6 methoxyquinoline: a narrative review

Multifunctional Deep Eutectic Solvent-Based Microemulsion for Transdermal Delivery of Artemisinin

Synthesis and Characterization of Dimeric Artesunate Glycerol Monocaprylate Conjugate and Formulation of Nanoemulsion Preconcentrate

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