Opposing Effects of Cannabis Use on Late Auditory Repetition Suppression in Schizophrenia Patients and Healthy Control Subjects

Rentzsch, Johannes; Kronenberg, Golo; Stadtmann, Ada; Neuhaus, Andres H.; Montag, Christiane; Hellweg, Rainer; Jockers-Scherübl, Maria C.

doi:10.1016/j.bpsc.2016.10.004

Cited by 4 publications

(4 citation statements)

References 74 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…One possible reason is the relevance of attention since many scholars have suggested that the distraction paradigm may enhance the detection of abnormal gating in patients with schizophrenia (34). Consequently, visual and auditory distractors were given in the N100/P200 trials (20,33,35,36). However, Rosburg et al suggest that the active control of attention is difficult in sensory gating experiments, since long intervals of no stimulation between the paired clicks are a necessary component of these experiments (58).…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

“…While P50 reflects the pre-attentive filtering of information processing, N100 sensory gating may be related to the filtering mechanism involved in triggering of attention, and P200 gating may be related to the filtering mechanism involved in the allocation of attention ( 8 , 9 , 32 ). Accordingly, some N100/P200 studies used auditory stimulation distractors ( 20 , 33 ), while some others used visual attention tasks ( 34 – 36 ). However, there are still some studies without distractors providing positive results( 7 , 24 , 26 , 32 ).…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

P50, N100, and P200 Auditory Sensory Gating Deficits in Schizophrenia Patients

Shen¹,

Chou²,

Lai³

et al. 2020

Front. Psychiatry

View full text Add to dashboard Cite

Background: Sensory gating describes neurological processes of filtering out redundant or unnecessary stimuli during information processing, and sensory gating deficits may contribute to the symptoms of schizophrenia. Among the three components of auditory event-related potentials reflecting sensory gating, P50 implies pre-attentional filtering of sensory information and N100/P200 reflects attention triggering and allocation processes. Although diminished P50 gating has been extensively documented in patients with schizophrenia, previous studies on N100 were inconclusive, and P200 has been rarely examined. This study aimed to investigate whether patients with schizophrenia have P50, N100, and P200 gating deficits compared with control subjects. Methods: Control subjects and clinically stable schizophrenia patients were recruited. The mid-latency auditory evoked responses, comprising P50, N100, and P200, were measured using the auditory-paired click paradigm without manipulation of attention. Sensory gating parameters included S1 amplitude, S2 amplitude, amplitude difference (S1-S2), and gating ratio (S2/S1). We also evaluated schizophrenia patients with PANSS to be correlated with sensory gating indices. Results: One hundred four patients and 102 control subjects were examined. Compared to the control group, schizophrenia patients had significant sensory gating deficits in P50, N100, and P200, reflected by larger gating ratios and smaller amplitude differences. Further analysis revealed that the S2 amplitude of P50 was larger, while the S1 amplitude of N100/P200 was smaller, in schizophrenia patients than in the controls. We found no correlations between sensory gating indices and schizophrenia positive or negative symptom clusters. However, we found a negative correlation between the P200 S2 amplitude and Bell's emotional discomfort factor/Wallwork's depressed factor. Conclusion: Till date, this study has the largest sample size to analyze P50, N100, and P200 collectively by adopting the passive auditory paired-click paradigm without distractors. With covariates controlled for possible confounds, such as age, education, smoking amount and retained pairs, we found that schizophrenia patients had significant sensory gating deficits in P50-N100-P200. The schizophrenia patients had demonstrated

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

P50, N100, and P200 Auditory Sensory Gating Deficits in Schizophrenia Patients

Shen¹,

Chou²,

Lai³

et al. 2020

Front. Psychiatry

View full text Add to dashboard Cite

show abstract

“…42 In addition to the P50 response, sensory gating has been studied less frequently also with N100 and P200 evoked potentials, reflecting early and late attentive information processing, respectively. 43,44 Impaired N100 sensory gating has been reported for schizophrenia 45 and bipolar disorder. 46 In addition, bipolar disorder has also been associated with impaired P200 sensory gating.…”

Section: Introductionmentioning

confidence: 99%

P50, N100, and P200 Sensory Gating in Panic Disorder

et al. 2020

Self Cite

View full text Add to dashboard Cite

Panic disorder (PD) has been linked to abnormalities in information processing. However, only little evidence has been published for sensory gating in PD. Sensory gating describes the brain’s ability to exclude stimuli of low relevance from higher level information processing, thereby sustaining efficient cognitive processing. Deficits in sensory gating have been associated with various psychiatric conditions, most prominently schizophrenia. In this case-control event-related potential study, we tested 32 patients with PD and 39 healthy controls in a double click paradigm. Both groups were compared with regard to pre-attentive (P50), early-attentive (N100), and late-attentive (P200) sensory gating indices. Contrary to a hypothesized deficit, PD patients and healthy controls showed no differences in P50, N100 and P200 values. These results suggest that sensory gating seems to be functional across the pre-attentive, early-attentive, and late-attentive time span in this clinical population. Given this consistency across auditory sensory gating indices, further research aiming to clarify information processing deficits in PD should focus on other neurophysiological markers to investigate information processing deficits in PD (eg, P300, error-related negativity or mismatch negativity).

show abstract

Opposing Effects of Cannabis Use on Electroencephalographic Measures of Auditory Repetition Suppression in Schizophrenia and Healthy Controls

Skosnik

D’Souza

2017

Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

View full text Add to dashboard Cite

Opposing Effects of Cannabis Use on Late Auditory Repetition Suppression in Schizophrenia Patients and Healthy Control Subjects

Cited by 4 publications

References 74 publications

P50, N100, and P200 Auditory Sensory Gating Deficits in Schizophrenia Patients

P50, N100, and P200 Auditory Sensory Gating Deficits in Schizophrenia Patients

P50, N100, and P200 Sensory Gating in Panic Disorder

Opposing Effects of Cannabis Use on Electroencephalographic Measures of Auditory Repetition Suppression in Schizophrenia and Healthy Controls

Contact Info

Product

Resources

About