Opposing effects of metformin mediated mTORC1 inhibition on IRES possessing anti-apoptotic proteins in breast cancer cell lines

Jahani, Zohreh; Davoodi, Jamshid

doi:10.1016/j.bbrc.2022.08.052

Cited by 3 publications

(2 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Frontiers in Physiology frontiersin.org effect on mTORC1, which is an essential switch of tumor growth (Jahani and Davoodi, 2022). A cohort study has shown that metformin use reduces the risk of luminal A breast cancer (estrogen/progesterone receptor positive, human epidermal growth factor receptor 2 negative) in postmenopausal patients with type 2 diabetes (Chikermane et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, metformin has been proven to have anti-mammary tumor effects in vivo and in vitro ( Pernicova and Korbonits, 2014 ). In estrogen/progesterone receptor positive human breast cancer cell lines (MCF7) and estrogen receptor/progesterone receptor/human epidermal growth factor receptor 2 negative cell lines (MDA-MB-231), metformin has an inhibitory effect on mTORC1, which is an essential switch of tumor growth ( Jahani and Davoodi, 2022 ). A cohort study has shown that metformin use reduces the risk of luminal A breast cancer (estrogen/progesterone receptor positive, human epidermal growth factor receptor 2 negative) in postmenopausal patients with type 2 diabetes ( Chikermane et al, 2022 ).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Scientometric analysis of lipid metabolism in breast neoplasm: 2012–2021

et al. 2023

View full text Add to dashboard Cite

Introduction: In recent years, more and more studies have proved that lipid metabolism plays an essential role in breast cancer’s proliferation and metastasisand also has a specific significance in predicting survival.Methods: This paper collected data from 725 publications related to lipid metabolism in breast neoplasm from 2012 to 2021 through the Web of Science Core Collection database. Bibliometrix, VOSviewer, and CiteSpace were used for the scientometrics analysis of countries, institutions, journals, authors, keywords, etc.Results: The number of documents published showed an increasing trend, with an average annual growth rate of 14.49%. The United States was the most productive country (n = 223, 30.76%). The journals with the largest number of publications are mostly from developed countries. Except for the retrieved topics, “lipid metabolism” (n = 272) and “breast cancer” (n = 175), the keywords that appeared most frequently were “expression” (n = 151), “fatty-acid synthase” (n = 78), “growth” (n = 72), “metabolism” (n = 67) and “cells“ (n = 66).Discussion: These findings and summaries help reveal the current research status and clarify the hot spots in this field.

show abstract

Section: Discussionmentioning

confidence: 99%