Opposing effects of pro‐ and anti‐inflammatory cytokine gene polymorphisms on the risk for breast cancer in western <scp>I</scp>ndian women: a pilot study

Joshi, N. N.; Bhat, Shreyas; Hake, Sujata; Kale, M; Kannan, Sadhana

doi:10.1111/iji.12098

Cited by 10 publications

(6 citation statements)

References 54 publications

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“…The previous reports on association of MCP-1 -2518 A/G polymorphism in different cancer types have been inconsistent (Table 3). Association of GG genotype of MCP1 -2518A/G polymorphism has also been documented in Western Indian breast cancer patients aged ≤40 years (Joshi et al, 2014). MCP-1-2518 GG genotype has been reported to be associated with increased risk of endometrial cancer in Turkish (Attar et al, 2010) and ovarian cancer in Chinese patients Wei et al, 2015).…”

Section: Discussionmentioning

confidence: 89%

“…India is a country having many population groups with varied ethnicities residing in different geographical regions. From India, only one study is available showing the association of GG genotype of MCP-1 -2518 A/G polymorphism with increased risk of breast cancer in Western Indians (Joshi et al, 2014). To date, there is no study on MCP-1 -2518 A/G polymorphism from North India in breast cancer.…”

Section: Association Of the -2518 A/g Polymorphism Of Mcp-1 With Breast Cancer In Punjab North-west Indiamentioning

confidence: 99%

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Association of the -2518 A/G Polymorphism of MCP-1 with Breast Cancer in Punjab, North-West India

Sambyal

Guleria²,

Kapahi³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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Background: Monocyte chemoattractant protein-1 (MCP-1) is a major chemokine thought to be responsible for monocyte and T-lymphocyte recruitment in acute inflammatory conditions and recruitment of macrophages in tumors. It is also implicated in cardiovascular disease, rheumatoid arthritis and chronic obstructive pulmonary disease. The aim of the present study was to investigate the correlation between MCP-1 -2518 A/G polymorphism and breast cancer risk in patients from Amritsar city of Punjab state in North-West India. Materials and Methods: We screened DNA samples of 200 sporadic breast cancer patients and 200 age and gender matched unrelated healthy individuals for MCP-1 -2518 A/G polymorphism using the PCR-RFLP method. Results: A significantly increased frequency of the GG genotype was observed in patients as compared to controls. Individuals carrying the MCP1 -2518GG genotype had a two fold risk for breast cancer (OR=2.06, 95%CI, 1.06-3.98; p=0.03). Genetic models analysis revealed a significant association between MCP-1 -2518 A/G polymorphism and cancer risk in homozygous co-dominant (OR=2.06, 95%CI, 1.06-3.98; p=0.03) and recessive (OR=1.97, 95%CI, 1.05-3.70; p=0.03) models. Conclusions: We conclude that the GG genotype of the MCP-1-2518 A/G polymorphism is associated with increased risk to breast cancer in Punjab, North-West India.

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Section: Discussionmentioning

confidence: 89%

Section: Association Of the -2518 A/g Polymorphism Of Mcp-1 With Breast Cancer In Punjab North-west Indiamentioning

confidence: 99%

Association of the -2518 A/G Polymorphism of MCP-1 with Breast Cancer in Punjab, North-West India

Sambyal

Guleria²,

Kapahi³

et al. 2015

Asian Pacific Journal of Cancer Prevention

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“…Interestingly, certain gene variations were associated with decreased BC risk (e.g. RAD52,OCT4,FASL,IGFIR,APE1,BARD1,IL4,IL21) (Kang et al, 2013;Liu et al, 2013a;You et al, 2013;Joshi et al, 2014b;Kang et al, 2014;Tulsyan et al, 2014;Xu et al, 2014;Wu et al, 2015), or both increased and decreased risk, depending on the gene variation investigated (e.g. MTHFR, ESR1, VEGF, FAS, OGG1, TGFB1) (Pooja et al, 2013;Kapahi et al, 2014;Lu et al, 2014;Luo et al, 2014;Wang et al, 2014c;Xu et al, 2014;Yu et al, 2014;Lu et al, 2015;Son et al, 2015).…”

Section: Non-modifiable Risk Factorsmentioning

confidence: 99%

A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

Youn

Han

2020

Asian Pac J Cancer Prev

105

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Background and Aim: Breast cancer is the most prevalent cancer in women. To date, regional differences in breast cancer risk factors have not been identified. The aim of our review was to gain a better understanding of the role of risk factors in women with breast cancer in Asia. Methods: We conducted a PubMed search on 15 March 2016, for journal articles published in English between 2011 and 2016, which reported data for human subjects in Asia with a diagnosis of breast cancer. Search terms included breast neoplasm, epidemiology, Asia, prevalence, incidence, risk and cost of illness. Studies of any design were included, except for review articles and meta-analyses, which were excluded to avoid duplication of data. No exclusions were made based on breast cancer treatment. We reported the results using the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Results: A total of 776 abstracts were retrieved. After screening against the eligibility criteria, 562 abstracts were excluded. The remaining 214 abstracts, which were published between 2013 and 2015, were included in this review. Results were summarized and reported under three categories: incidence, prevalence or outcomes for breast cancer in Asia; modifiable risk factors; and non-modifiable risk factors. We found that the increased risk of breast cancer among participants from Asia was associated with older age, family history of breast cancer, early menarche, late menopause, high body mass index, being obese or overweight, exposure to tobacco smoke, and high dietary intake of fats or fatty foods. In contrast, intake of dietary fruits, vegetables, and plant-and soy-based products was associated with a decreased breast cancer risk. While based on limited data, when compared to women from the United States, women from Asia had a decreased risk of breast cancer. Conclusions: This review of 214 abstracts of studies in Asia, published between 2013 and 2015, confirmed the relevance of known non-modifiable and modifiable risk factors for women with breast cancer.

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“…Eighty potentially eligible studies were retrieved as full texts, 39 of which were eligible for inclusion in the meta-analysis. Precisely, 23 studies [9,12,13,[26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45] covered the TGF-β1 29T>C polymorphism (also known as Pro10Leu, T869C, rs1982073, and rs1800470), whereas 13 studies [9,[28][29][30]35,40,[46][47][48][49][50][51][52] covered the TGF-β1-509 C/T polymorphism (also known as −1349C>T and rs1800469), and 13 studies [9,21,28,31,33,35,39,47,[53][54][55][56][57]…”

Section: Characteristics Of Studies Included In the Meta-analysismentioning

confidence: 99%

Association of TGF-β1 Polymorphisms with Breast Cancer Risk: A Meta-Analysis of Case–Control Studies

Krishna

Jana

Panda³

et al. 2020

Cancers

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Reports on the association of TGF-β1 polymorphisms with breast cancer (BC) have been conflicting, inconsistent, inconclusive, and controversial. PubMed, EMBASE, and Google Scholar were used to identify studies on TGF-β1 polymorphisms and BC risk. Data were extracted independently, and of the initial 3043 studies, 39 case-control studies were eligible for inclusion in the meta-analysis. Information from these studies was extracted, and the overall associations of three TGF-β1 polymorphisms (TGF-β1 29>T/C, TGF-β1-509 C/T, and TGF-β1*6A) with BC risk were analyzed using overall allele, homozygous, heterozygous, recessive, and dominant models. None of the three TGF-β1 polymorphisms studied had a significant influence on the development of BC. However, stratified analysis revealed a positive correlation between the TGF-β1 29T>C polymorphism and BC risk according to a heterozygous model of the Asian population (odds ratio (OR) = 1.115, 95% confidence interval (CI) = 1.006–1.237, p = 0.039). Interestingly, this polymorphism was associated with lower odds of BC according to a heterozygous model of the Middle Eastern population (OR = 0.602, 95% CI = 0.375–0.966, p = 0.035). Thus, our analysis of large datasets indicates that the TGF-β1 29T>C polymorphism is significantly associated with BC risk in the Asian population. In contrast, the TGF-β1*6A and TGF-β1-509 C/T polymorphisms failed to show an association with BC.

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Opposing effects of pro‐ and anti‐inflammatory cytokine gene polymorphisms on the risk for breast cancer in western Indian women: a pilot study

Cited by 10 publications

References 54 publications

Association of the -2518 A/G Polymorphism of MCP-1 with Breast Cancer in Punjab, North-West India

Association of the -2518 A/G Polymorphism of MCP-1 with Breast Cancer in Punjab, North-West India

A Review of the Epidemiology of Breast Cancer in Asia: Focus on Risk Factors

Association of TGF-β1 Polymorphisms with Breast Cancer Risk: A Meta-Analysis of Case–Control Studies

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