2021
DOI: 10.5551/jat.60848
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Opposing Responses of the Calcium Channel Blocker Nicardipine to Vascular Stiffness in the Elastic and Muscular Arteries in Rabbits

Abstract: The cardio-ankle vascular index (CAVI) consists of intrinsic and functional arterial stiffness mainly regulated by vasoactive compounds. A new stiffness index of the aorta (aBeta) and iliac-femoral arteries (ifBeta) was determined by applying the CAVI theory to the whole aorta and iliac-femoral arteries. We investigated the changes in aBeta and ifBeta in response to decreased blood pressure (BP) induced by the Ca 2 channel blocker nicardipine to elucidate the involvement of Ca 2 in aBeta and ifBeta.Methods: Pr… Show more

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Cited by 3 publications
(7 citation statements)
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“…This reciprocal response between the muscular (common iliac to femoral arteries) and elastic (aorta) arteries by administration of vasodilating agents, looks strange. However, we previously reported a decrease in ifBeta and an increase in aBeta in normal rabbits in response to the decline in BP induced by the administration of vasodilating agents, such as phentolamine, an α-adrenergic blocker, [ 13 ] and nicardipine, a Ca 2+ -channel blocker [ 14 ]. Then, the reciprocal response to NTG observes in normal rabbit this time might be normal response, even though precise reason is obscure.…”
Section: Discussionmentioning
confidence: 99%
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“…This reciprocal response between the muscular (common iliac to femoral arteries) and elastic (aorta) arteries by administration of vasodilating agents, looks strange. However, we previously reported a decrease in ifBeta and an increase in aBeta in normal rabbits in response to the decline in BP induced by the administration of vasodilating agents, such as phentolamine, an α-adrenergic blocker, [ 13 ] and nicardipine, a Ca 2+ -channel blocker [ 14 ]. Then, the reciprocal response to NTG observes in normal rabbit this time might be normal response, even though precise reason is obscure.…”
Section: Discussionmentioning
confidence: 99%
“…Figure 1 illustrates an experimental set-up. The experimental procedures were similar to those reported previously [13,14]. The rabbits were anesthetized by intravenous administration of pentobarbital sodium at a dose of 20-30 mg/ kg (Sommunopentyl, Kyoritsu Pharmaceutical, Co. Ltd., Japan) and fixed in the supine position.…”
Section: Surgical Proceduresmentioning
confidence: 99%
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“…However, the “gold-standard” two-point-dependent cfPWV did not change during provocations, suggesting the constant nature of large arterial elasticity in this homogenous population during the physical modulation of resistance. In contrast, in invasive rabbit models, Horikoshi et al proved a decrease in stiffness in muscular arteries and an opposite increase in aortic stiffness during continuous systemic, intravenous dihydropyridine (DHP)-type calcium channel blocking agent or phentolamine administration [ 28 , 29 ]. Nevertheless, the systemic DHP-type calcium channel blocking agent treatment in humans resulted in decreased integrated elastic and muscular stiffness, represented by the cardio-ankle vascular index [ 30 ].…”
Section: Discussionmentioning
confidence: 99%
“…Elastic and muscular arteries have been shown to differ in their microstructural and physiological properties [20][21][22]. Katsuda et al [23,24] previously applied the new indices derived from CAVI theory [10][11][12][13] to the aorta (aBeta), common iliac and femoral (ifBeta) arteries, and arterial tree from the origin of the aorta (oA) to the distal end of the left femoral artery (fA) (aifBeta), respectively, to assess the response of these arteries to some vasodilating drugs, separately. They found that the elastic and muscular arteries responded differently to the alpha-receptor blocker, phentolamine [23], and the calcium channel blocker, nicardipine [24].…”
Section: Introductionmentioning
confidence: 99%