2013
DOI: 10.4049/jimmunol.1203229
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Opposing Roles of STAT4 and Dnmt3a in Th1 Gene Regulation

Abstract: The Signal Transducer and Activator of Transcription factor STAT4 is a critical regulator of Th1 differentiation and inflammatory disease. Yet, how STAT4 regulates gene expression is still unclear. In this report, we define a STAT4-dependent sequence of events including H3K4 methylation, Jmjd3 association with STAT4 target loci, and a Jmjd3-dependent decrease in H3K27 trimethylation and DNA methyltransferase (Dnmt) 3a association with STAT4 target loci. Dnmt3a has an obligate role in repressing Th1 gene expres… Show more

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Cited by 44 publications
(25 citation statements)
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“…Other TFs are involved in regulating the epigenome during T cell activation. Recent studies discussed the roles of STATs, GATA3, and T-BET (Vahedi et al, 2012;Durant et al, 2010;Wan et al, 2015;Pham et al, 2013;Kanhere et al, 1AD). Moreover, although AP-1 is required for chromatin remodeling at the regulatory elements for T cell activation, our study does not completely answer the question of specificity: many cell types express AP-1 and NFATs but do not induce T cell genes such as IL2 (Armstrong, 2004;Turner et al, 1998;Ranger et al, 2000;Jauliac et al, 2002).…”
Section: Discussionmentioning
confidence: 99%
“…Other TFs are involved in regulating the epigenome during T cell activation. Recent studies discussed the roles of STATs, GATA3, and T-BET (Vahedi et al, 2012;Durant et al, 2010;Wan et al, 2015;Pham et al, 2013;Kanhere et al, 1AD). Moreover, although AP-1 is required for chromatin remodeling at the regulatory elements for T cell activation, our study does not completely answer the question of specificity: many cell types express AP-1 and NFATs but do not induce T cell genes such as IL2 (Armstrong, 2004;Turner et al, 1998;Ranger et al, 2000;Jauliac et al, 2002).…”
Section: Discussionmentioning
confidence: 99%
“…KDM6B can directly associate with key transcription factors, such as p53 (67,68), p65, and p50 NF-KB subunits (37) and STAT (69,70) and SMAD (71) family members, enhancing their functions. In turn, a reciprocal mode of regulation Table 3.…”
Section: Discussionmentioning
confidence: 99%
“…Cells were then spin‐infected with control GFP, Bcl6‐GFP–expressing retroviruses (RVs). For co‐infection experiments, either control H2K k or Bcl6‐H2K k ‐expressing RVs were co‐transduced with either control GFP or T‐bet‐GFP–expressing RVs. After infection, supernatants were substituted with fresh medium containing 10 U/mL recombinant human IL‐2.…”
Section: Methodsmentioning
confidence: 99%