Opposite CD curves in chromophoric derivatives of 3‐substituted 5‐and 6‐membered cyclic amines

Abstract

Absolute configuration was assigned to 3‐isopropylpyrrolidine by chemical correlation with R‐3‐isopropylsuccinic acid. The comparison between CD curves of 3‐substituted piperidines, morpholines and pyrrolidine having the same chirality shows that the chiroptical properties of these five and six‐membered cyclic amine derivatives are opposite.