Opposite effects of depressant and convulsant barbiturate stereoisomers on acetylcholine release from the rat hippocampus in vivo

Abstract

Our results demonstrated that R(-)-MPPB decreased, while S(+)-MPPB increased, rat hippocampal ACh release and that the inhibitory effects of R(-)-MPPB may involve the GABA(A) receptor in vivo. These data imply that changes in hippocampal ACh due to these agents may be related to their central inhibitory and stimulatory actions in vivo.

The impact of acetylcholinesterase inhibitors on the extracellular acetylcholine concentrations in the adult rat brain: A meta‐analysis

“… The average ACh levels (± SEM) in nM within the hippocampus of rats. Basal value (Harada et al,2000; Huang et al,2008; Li et al,2007); NEO 0.1 μM (Gold et al,2011; Reid et al,1999); NEO 0.2 μM (Psych et al,2005); NEO 0.3 μM (Biton et al,2007); NEO 0.5 μM (Mark et al,1996); NEO 1 μM (Kiewert et al,2004; Steinberg et al,1998); NEO 10 μM (Claustre et al,2006); NEOBr 0.1 μM (Acquas et al,2000, 2001; Moor et al,1995; Pisanu et al,2006; Zhelyazkova‐Savova et al,1999); NEOBr 1 μM (Moor et al,1994); NEOBr 10 μM (Keita et al,2000); PHYS 10 μM (Ikarashi and Yuzurihara,2002; Inagawa et al,2004a; Tani et al,1998; Wang et al,2000); PHYS 100 μM (Hasegawa et al,1996; Horii et al,1994; Inagawa et al,2004); PHYSS 7 μM (Giovannini et al,1994; Rakovska et al,1998,2002). …”