Opposite effects of lithium and rubidium on neurohormone-stimulated cyclic AMP accumulation in rat brain

Geisler, A.; Klysner, R.; Andersen, P. H.

doi:10.1007/978-94-011-7318-6_4

Cited by 7 publications

(2 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As a reverse proof, in donor (not lithium-induced) neutrophils, our group confirmed that lithium reduced chemotaxis as a result of excessive tubulin aggregation, an effect that could be antagonized by the microtubular-disaggregating agent vincristine [30,31] or by another cation, rubidium [32]; the latter could also increase bactericidal activity [32]. Accordingly, the potentiating effect of rubidium on cAMP is antagonized by the simultaneous addition of the two cations [33].…”

Section: Qualitative Effectsmentioning

confidence: 65%

Lithium and hematology: established and proposed uses

Focosi

Azzarà

Kast

et al. 2008

Journal of Leukocyte Biology

View full text Add to dashboard Cite

Lithium (as lithium carbonate) is an inexpensive drug, widely used in psychiatry for over 50 years in treatment of mood instability (bipolar disorder) and as an adjunct to antidepressants. Hematological effects of neutrophilia and increased circulating CD34+ cells of marrow origin have long been known. Lithium was at the center of hematological investigations in the 1980s, but no definitive use in hematology has yet emerged. We review evidence that lithium increases G-CSF and augments G-CSF effects. We suggest possible therapeutic uses of lithium in neutropenia. In bone marrow transplantation, preharvest lithium-assisted hematopoietic stem cell mobilization may be useful as well.

show abstract