Opposite Effects on Kallikrein Excretion of Natriuretic Doses of Angiotensin Infused into the Dog and the Rat: Reversal of the Effect in the Rat by Atrial Natriuretic Peptide

Mills, Ivor H.; Newport, Pamela A.; Wakabayashi, Yasuhisa; Spinelli, F.

doi:10.1007/978-1-4615-9543-4_101

Cited by 3 publications

(3 citation statements)

References 3 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…(1986) have recently shown that in the perfused rat kidney, bradykinin and lysylbradykinin are rapidly converted into the corresponding des-arginine compounds and these then lose their vasodilator activity and become vasoconstrictors by acting on the B, receptors. Also, it has been reported that infusion of angiotensin in the rat reduces the excretion of kallikrein (Mills et al, 1989). One would then not expect an increase in kallikrein to lower blood pressure unless it were acting only as a stimulator of phospholipase.…”

Section: Discussionmentioning

confidence: 99%

Depressor effect of magnesium lithospermate B, a component of Salviae Miltiorrhizae Radix, in spontaneously hypertensive rats

Yokozawa

Lee

Chung

et al. 1994

Phytotherapy Research

View full text Add to dashboard Cite

The effects of magnesium lithospermate B on blood pressure were examined in spontaneously hypertensive rats. Systolic, mean and diastolic blood pressures were decreased after magnesium lithospermate B administration, whereas the urinary levels of kallikrein, prostaglandin E,, sodium and potassium were increased. The mechanisms of the depressor action of magnesium lithospermate B were discussed on the basis of these findings.

show abstract

Section: Discussionmentioning

confidence: 99%

Depressor effect of magnesium lithospermate B, a component of Salviae Miltiorrhizae Radix, in spontaneously hypertensive rats

Yokozawa

Lee

Chung

et al. 1994

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…However, Guimaràes et al [34] have recently shown that in the perfused rat kidney, bradykinin and lysylbradykinin are rapidly converted into the corresponding des-arginine compounds and these then lose their vasodilator activ ity and become vasoconstrictors by acting on the B, recep tors. Also, it has been reported that infusion of angiotensin in the rat reduces the excretion of kallikrein [35]. One would then not expect an increase in kallikrein to lower blood pressure unless it were acting only as a stimulator of phos pholipase.…”

Section: Discussionmentioning

confidence: 99%

Effect of Magnesium Lithospermate B in Rats with Sodium-Induced Hypertension and Renal Failure

Yokozawa

Lee²,

Oura³

et al. 1992

Nephron

View full text Add to dashboard Cite

To evaluate the antihypertensive effect of magnesium lithospermate B isolated from Salviae miltiorrhizae radix, determinations of blood pressure and urinary excretions of sodium, potassium, prostaglandin E₂ (PGE₂) and kallikrein, which have been proposed to play an important role in the regulation of blood pressure, were made in rats with sodium-induced hypertension and renal failure. In rats given magnesium lithospermate B, blood pressure was significantly decreased, whereas urinary excretion of electrolytes was significantly increased. Urinary PGE₂ excretion following administration of magnesium lithospermate B increased as the dose of the compound was stepped up. The activity of kallikrein in urine was also increased by the treatment. From these results, the blood pressure-lowering action of magnesium lithospermate B may be due in part to enhancement of the kallikrein-prostaglandin system.

show abstract

“…In the dog it has been shown that kallikrein excretion is increased to comparable levels by volume expansion with 5% glucose or normal saline (Mills et al 1989). Kallikrein excretion was increased by natriuretic doses of angiotensinII given intra-arterially, except when the pressure acting at the kidney was prevented from rising (Mills & Newport, 1978) or prostaglandin production was inhibited (Mills & Newport, 1979).…”

mentioning

confidence: 99%

Urinary kallikrein in the rat: stimulation with angiotensin infusion but depression with increasing sodium concentration.

Mills

Lee

Brownlee

1994

The Journal of Physiology

View full text Add to dashboard Cite

1. The kallikrein response to angiotensin II infusion in the conscious rat was studied to compare it with the response in the dog. 2. Active kallikrein was measured by the aprotinin-suppressible esterase technique in 20 min periods. Angiotensin (5 x 10-9 to 5 x 10-2 ug min-') was infused in 10 mm saline in period 10 (group A), or in 90 mm saline in periods 10-12 (group B). 3. In group A, no dose of angiotensin was antinatriuretic. Natriuresis and urinary sodium concentration were dose dependent. 4. Kallikrein excretion was dose dependent with angiotensin (P < 0-0001) and inversely correlated with urinary sodium concentration (P = 0-011). In natriuretic and nonnatriuretic rats, kallikrein excretion after angiotensin was inversely correlated with urinary sodium concentration in the preceding period.5. In group B, natriuresis and urinary sodium concentration were dose dependent. Kallikrein excretion in periods 10-13 was inversely correlated with urinary sodium concentration in the preceding period (P = 0-0001) and inversely correlated with urinary osmolality in periods 9-13.6. Infusion of angiotensin II at 5 x 1W6 jug min' led to antinatriuresis. 7. Formulae were derived which enabled the opposing effects of angiotensin and urinary sodium concentration on kallikrein excretion to be separated. In group A both these effects were statistically significant only in the natriuretic rats (natriuresis > 20 'tmol per period). In group B the formulae showed a dose-dependent rise in kallikrein excretion, which was counteracted by the decrease in kallikrein excretion associated with the increasing urinary sodium concentration.8. With infusions of 0-9% saline, kallikrein excretion in periods 10-13 was inversely correlated with urinary sodium concentration in the preceding period (P = 0-001). 9. The overall effect in the rat differs from that in the dog, where kallikrein increases with angiotensin natriuresis and dilution of the urine occurs.Although there have been several reviews of the kallikrein-kinin system in relationship to renal function, the physiological and pharmacological picture is still not

show abstract

Opposite Effects on Kallikrein Excretion of Natriuretic Doses of Angiotensin Infused into the Dog and the Rat: Reversal of the Effect in the Rat by Atrial Natriuretic Peptide

Cited by 3 publications

References 3 publications

Depressor effect of magnesium lithospermate B, a component of Salviae Miltiorrhizae Radix, in spontaneously hypertensive rats

Depressor effect of magnesium lithospermate B, a component of Salviae Miltiorrhizae Radix, in spontaneously hypertensive rats

Effect of Magnesium Lithospermate B in Rats with Sodium-Induced Hypertension and Renal Failure

Urinary kallikrein in the rat: stimulation with angiotensin infusion but depression with increasing sodium concentration.

Contact Info

Product

Resources

About