OPRM1 and Diagnosis-Related Posttraumatic Stress Disorder in Binge-Drinking Patients Living with HIV

Nugent, Nicole R.; Lally, Michelle; Brown, Larry K.; Knopik, Valerie S.; McGeary, John E.

doi:10.1007/s10461-011-0095-8

Cited by 20 publications

(18 citation statements)

References 79 publications

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“…Our results differ from those of many studies that have observed such a pathway (Goldstein et al, 2010;Grayson & Nolen-Hoeksema, 2005;Nugent et al, 2012;Simpson, 2003;Simpson et al, 2014). In addition, we did not find any gender differences when the model was tested separately for males and females.…”

Section: Discussioncontrasting

confidence: 99%

“…For example, many of the studies measured childhood abuse or neglect any time before age 18 (Goldstein et al, 2010;Grayson & Nolen-Hoeksema, 2005;Nugent et al, 2012;Simpson, 2003;Simpson et al, 2014), whereas we measured trauma occurring much earlier. The earlier exposure to trauma would be expected to have a greater effect on developing emotion regulation.…”

Section: Discussionmentioning

confidence: 99%

“…This work was initiated to find support for the self-medication theory that posits that individuals with a trauma history will use substances to decrease negative affect (Khantzian, 1985). Although using substances may be an effective, yet damaging, method for coping with the distressing symptoms of trauma, the authors of recent studies have argued that alcohol may also be a means to increase positive emotion (Goldstein et al, 2010;Grayson and Nolen-Hoeksema, 2005;Nugent et al, 2012;Simpson, 2003;Simpson et al, 2014). For example, Simpson and colleagues (2014) found that both coping motives for dealing with negative affect and enhancement motives to increase positive affect moderated the relationship between sameday alcohol use and PTSD symptoms as well as increased drinking in those men and women with comorbid PTSD and alcohol dependence.…”

mentioning

confidence: 99%

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Coping Expectancies, Not Enhancement Expectancies, Mediate Trauma Experience Effects on Problem Alcohol Use: A Prospective Study From Early Childhood to Adolescence

Jester

Steinberg

Heitzeg

et al. 2015

J. Stud. Alcohol Drugs

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ABSTRACT. Objective:The relationship between experiencing trauma and increased alcohol consumption has been well established. Exposure to childhood trauma has been linked to both early onset of drinking and problematic substance use. However, the mechanisms underlying this relationship remain unclear. The results of early work suggested that drinking to relieve negative affect (i.e., drinking to cope) was driving this connection. However, the findings of more recent work suggest that drinking might be used to enhance positive affect as a way of addressing the aftereffects of early trauma. The current study looked at these two drinking expectancies as indirect pathways between the experience in early childhood of living in a home with parental violence and peak alcohol use in emerging adulthood. Method: Participants were 1,064 children and their parents involved in a longitudinal community study of children at high risk for the development of alcoholism and a community contrast group of those at lower risk. Baseline assessment was at age 3-5 years, self-reports of internalizing behavior and drinking expectancies were obtained at age 12-14, and drinking measures were assessed at age 18-20. Results: Results indicated that coping expectancy was a mediator of the relationship between early childhood trauma and later peak alcohol use, whereas enhancement expectancy was not. Conclusions: Children living in homes with parental violence were more likely to develop ineffective coping strategies, such as using alcohol to decrease negative affect. These results support the self-medication theory. They also demonstrate the long-term effects of early life experience on drinking behavior in early adulthood. (J. Stud. Alcohol Drugs, 76, 781-789, 2015)

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

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Coping Expectancies, Not Enhancement Expectancies, Mediate Trauma Experience Effects on Problem Alcohol Use: A Prospective Study From Early Childhood to Adolescence

Jester

Steinberg

Heitzeg

et al. 2015

J. Stud. Alcohol Drugs

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“…Similarly, other studies suggest that a polymorphism in the OPRM1 gene (opioid receptor μ–1) is associated with less severe PTSD symptoms (138). Regarding specific PTSD-related symptoms, κ opioid receptor availability in the amygdala-anterior cingulate cortex-ventral striatal circuit mediates the expression of dysphoria where lower κ opioid receptor is associated with greater severity of trauma-related loss symptoms (139).…”

Section: Pharmacotherapy Approaches To Fear- and Anxiety-related Disomentioning

confidence: 82%

An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials

Bowers

Ressler

2015

Biological Psychiatry

126

101

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Posttraumatic stress disorder (PTSD) manifests after exposure to a traumatic event and is characterized by avoidance/numbing, intrusive symptoms and flashbacks, mood and cognitive disruptions, and hyperarousal/reactivity symptoms. These symptoms reflect dysregulation of the fear system likely caused by poor fear inhibition/extinction, increased generalization, and/or enhanced consolidation or acquisition of fear. These phenotypes can be modeled in animal subjects using Pavlovian fear conditioning, allowing investigation of the underlying neurobiology of normative and pathological fear. Pre-clinical studies reveal a number of neurotransmitter systems and circuits critical for aversive learning and memory, which have informed the development of therapies used in human clinical trials. In this review, we discuss the evidence for a number of established and emerging pharmacotherapies and device-based treatments for PTSD that have been developed via a bench to bedside translational model.

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“…All behavioral testing was videotaped with a Sony Digital Video Camera with NightShot feature for recording in low light. The time spent sniffing the stimulus mouse in the cylinder was measured, as it has been previously shown to be a direct and sensitive measure of sociability (Moy et al, 2007). All testing was conducted in dim light conditions (1-2 lux).…”

Section: Methodsmentioning

confidence: 99%

Mouse Model ofOPRM1(A118G) Polymorphism Increases Sociability and Dominance and Confers Resilience to Social Defeat

Briand

Hilário²,

Dow

et al. 2015

J. Neurosci.

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A single nucleotide polymorphism (SNP) in the human -opioid receptor gene (OPRM1 A118G) has been widely studied for its association in drug addiction, pain sensitivity, and, more recently, social behavior. The endogenous opioid system has been shown to regulate social distress and reward in a variety of animal models. However, mechanisms underlying the associations between the OPRM1 A118G SNP and these behaviors have not been clarified. We used a mouse model possessing the human equivalent nucleotide/amino acid substitution to study social affiliation and social defeat behaviors. In mice with the Oprm1 A112G SNP, we demonstrate that the G allele is associated with an increase in home-cage dominance and increased motivation for nonaggressive social interactions, similar to what is reported in human populations. When challenged by a resident aggressor, G-allele carriers expressed less submissive behavior and exhibited resilience to social defeat, demonstrated by a lack of subsequent social avoidance and reductions in anhedonia as measured by intracranial self-stimulation. Protection from social defeat in G-allele carriers was associated with a greater induction of c-fos in a resilience circuit comprising the nucleus accumbens and periaqueductal gray. These findings led us to test the role of endogenous opioids in the A112G mice. We demonstrate that the increase in social affiliation in G carriers is blocked by pretreatment with naloxone. Together, these data suggest a mechanism involving altered hedonic state and neural activation as well as altered endogenous opioid tone in the differential response to aversive and rewarding social stimuli in G-allele carriers.

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OPRM1 and Diagnosis-Related Posttraumatic Stress Disorder in Binge-Drinking Patients Living with HIV

Cited by 20 publications

References 79 publications

Coping Expectancies, Not Enhancement Expectancies, Mediate Trauma Experience Effects on Problem Alcohol Use: A Prospective Study From Early Childhood to Adolescence

Coping Expectancies, Not Enhancement Expectancies, Mediate Trauma Experience Effects on Problem Alcohol Use: A Prospective Study From Early Childhood to Adolescence

An Overview of Translationally Informed Treatments for Posttraumatic Stress Disorder: Animal Models of Pavlovian Fear Conditioning to Human Clinical Trials

Mouse Model ofOPRM1(A118G) Polymorphism Increases Sociability and Dominance and Confers Resilience to Social Defeat

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