2010
DOI: 10.4081/rt.2010.e42
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Opsoclonus as a suspected paraneoplastic syndrome of endometrial cancer

Abstract: Paraneoplastic opsoclonus is well described in neuroblastoma. In the adult oncologic population, opsoclonus is seen usually within the context of opsoclonus–myoclonus ataxia and is associated most strongly with small-cell lung cancer. Patients with paraneoplastic opsoclonus are often seronegative. Patients with gynecologic malignancies are known to be predisposed to paraneoplastic syndromes; however, we describe the first case of paraneoplastic opsoclonus in association with endometrial cancer.

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Cited by 3 publications
(7 citation statements)
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“…OMS could develop in the course of metabolic, toxic, or structural impairment of the central nervous system. [ 1 3 , 6 , 16 , 17 ] In both paraneoplastic opsoclonus-myoclonus syndrome (P-OMS) and idiopathic opsoclonus-myoclonus syndrome (I-OMS) humoral and cell-mediated immune mechanisms are involved, with the presumed dominant role of antibodies. [ 5 , 6 , 10 ] In some patients with P-OMS, a variety of onconeuronal antibodies are found (anti-Hu, anti-Yo, anti-Ri, anti-CRMP-5/CV2, anti-Ma1, anti-Ma2, anti-Tr, anti-Zic-4, anti-amphiphysin), although the majority of patients are seronegative (1, 3, 4, 5, 6, 18).…”
Section: Discussionmentioning
confidence: 99%
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“…OMS could develop in the course of metabolic, toxic, or structural impairment of the central nervous system. [ 1 3 , 6 , 16 , 17 ] In both paraneoplastic opsoclonus-myoclonus syndrome (P-OMS) and idiopathic opsoclonus-myoclonus syndrome (I-OMS) humoral and cell-mediated immune mechanisms are involved, with the presumed dominant role of antibodies. [ 5 , 6 , 10 ] In some patients with P-OMS, a variety of onconeuronal antibodies are found (anti-Hu, anti-Yo, anti-Ri, anti-CRMP-5/CV2, anti-Ma1, anti-Ma2, anti-Tr, anti-Zic-4, anti-amphiphysin), although the majority of patients are seronegative (1, 3, 4, 5, 6, 18).…”
Section: Discussionmentioning
confidence: 99%
“…P-OMS is mainly associated with small cell lung carcinoma, breast adenocarcinoma and, in younger patients, ovarian teratoma. [ 1 6 , 16 , 17 ] Less frequently, paraneoplastic OMS coexists with other types of tumors such as non-small cell lung carcinoma, sarcoma, chondrosarcoma, Hodgkin and non-Hodgkin lymphoma, carcinoma of the thyroid, thymus, uterus, and bladder, and melanoma. [ 1 3 , 16 ] In more than 50% of cases, P-OMS precedes the diagnosis of a neoplasm, regardless of the type of tumor.…”
Section: Discussionmentioning
confidence: 99%
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