Optic Disc and Visual Field Changes after Trabeculectomy

Kotecha, Aachal; Spratt, Alexander; Bunce, Catey; Garway-Heath, David F.; Khaw, PT; Viswanathan, Ananth C.

doi:10.1167/iovs.08-3115

Cited by 31 publications

(25 citation statements)

References 39 publications

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“…8 Our results showed a short-term improvement in global RNFL thickness after trabeculectomy. However, no definitive functional conclusions can be reached from these anatomical changes upon lowering IOP.…”

Section: Short-term Changes After Trabeculectomy M Figus Et Alsupporting

confidence: 60%

“…The lack of an absolute structure-function correlation may be due to the different levels of measurement noise displayed by the devices used to detect change, and it has been suggested that structural and functional methods can be considered as independent indicators of glaucoma damage. 8,17,18 Scanty literature is available on the association of functional and morphological changes after surgical IOP decrease. Only recently a paper with long-term data has been published, showing that one third of eyes continued to have progression of glaucoma at 5 years after trabeculectomy.…”

Section: Short-term Changes After Trabeculectomy M Figus Et Almentioning

confidence: 99%

“…Only recently a paper with long-term data has been published, showing that one third of eyes continued to have progression of glaucoma at 5 years after trabeculectomy. 8 The authors suggest that the degree of IOP reduction after trabeculectomy may have an important role in the progression of glaucoma. Other authors found a small change of few microns of RNFL thickness 4 or in MD 5 after medical or surgical IOP reduction, even if the efficacy of the treatments was similar to our results.…”

Section: Short-term Changes After Trabeculectomy M Figus Et Almentioning

confidence: 99%

“…4,5 Reports about the ONH have demonstrated a significant change of some parameters and reversal of cupping. [6][7][8] Structure and function relationship after trabeculectomy have just been previously studied. Some reports have suggested that improvement in disk appearance would correspond to improvement of visual function, 9,10 other authors have not shown any significant change of visual field after trabeculectomy.…”

Section: Introductionmentioning

confidence: 99%

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Short-term changes in the optic nerve head and visual field after trabeculectomy

Figus

Lazzeri

Nardi

et al. 2011

Eye

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Aims or Purpose To evaluate short-term changes in optic nerve head topography and visual field induced by surgical reduction of intraocular pressure. Methods A prospective study was performed on 56 eyes of 56 patients with uncontrolled primary open-angle glaucoma despite maximum medical therapy, which underwent trabeculectomy. Optic nerve head evaluations by means of Heidelberg Retina Tomograph, and visual field tests were performed pre-operatively, and at 3 and 6 months after surgery. Differences in intraocular pressure, visual field indices, and Heidelberg Retina Tomograph parameters were evaluated with the t-test for paired data. A linear regression model was calculated to analyze the relationship between intraocular pressure reduction and visual field changes, and optic nerve head changes. Results Mean intraocular pressure decreased from 24.4 ± 5.0 mm Hg to 12.1 ± 3.1 mm Hg (month 3, Po0.001), and 10.6±2.8 mm Hg (month 6, Po0.001) after trabeculectomy. Mean retinal nerve fiber layer thickness (baseline, 0.19±0.034; month 3, 0.24 ± 0.039, P ¼ 0.05; month 6, 0.21 ± 0.037, P ¼ 0.05) showed a statistical significant change compared with baseline values. Conclusions In this 6-months study, a significant increase in retinal nerve fiber layer thickness was detected after glaucoma filtration surgery.

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Section: Short-term Changes After Trabeculectomy M Figus Et Alsupporting

confidence: 60%

Section: Short-term Changes After Trabeculectomy M Figus Et Almentioning

confidence: 99%

Section: Short-term Changes After Trabeculectomy M Figus Et Almentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Short-term changes in the optic nerve head and visual field after trabeculectomy

Figus

Lazzeri

Nardi

et al. 2011

Eye

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“…Glaucoma is a progressive optic neuropathy that may cause irreversible visual field defects (1). Intraocular pressure (IOP) is a major risk factor for the development and progression of the disease (2).…”

Section: Introductionmentioning

confidence: 99%

Bleb yetersizliğinin tedavisinde subkonjonktival 5-fluorourasil kullanımının sonuçları: Olgu serisi

Yılmaz¹,

Aygıt²,

Erdur³

et al. 2015

Ege Tıp Dergisi

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Aim: To evaluate the efficacy of 5-Fluorouracil (5-FU) injections in eyes with bleb failure and uncontrolled intraocular pressure (IOP) after trabeculectomy. Materials and Methods:Fifteen eyes of 15 patients (6 female, 9 male) were included in this retrospective study. All patients had trabeculectomy surgery for the treatment of primary open angle glaucoma. During the first year followups, cases with IOP higher than 21 mmHg and ineffective blebs were considered as bleb failure. We used 5-FU subconjunctival injections, in the same concentration (5 mg) but in different numbers, to treat the bleb failure and lower the IOP. The efficacy of the treatment was evaluated. Results:The mean age was 59.3±12.4 years (range 43-74 years). The mean 5-FU injection count was 5.27±1.58 injections (range 2-7). The mean IOP was reduced to 17.07±7.10 mmHg after treatment. There was a statistically significant difference in IOP levels before and after the injections (p<0.05).Conclusion: 5-FU injection treatment is safe and effective for the treatment of bleb failure after trabeculectomy.Keywords: Trabeculectomy, bleb failure, 5-FU, 5-fluorouracil. Öz Amaç: Trabekülektomi sonrasında bleb yetersizliği ve göz içi basınç (GİB) yüksekliği olan gözlerde 5-Fluorouracil (5-FU) enjeksiyonlarının etkinliğini değerlendirmek. Gereç ve Yöntem: Retrospektif çalışmaya 15 hastanın 15 gözü (6 kadın, 9 erkek) dahil edildi. Tüm hastalar daha önce açık açılı glokom nedeniyle trabekülektomi olmuştu. Birinci yıl takipleri sırasında, GİB'ının 21 mmHg'den yüksek olması ve inefektif bleb varlığı bleb yetersizliği olarak değerlendirildi. Bleb yetersizliğini tedavi etmek ve GİB'ını düşürmek için bu hastalara aynı dozda (5 mg) fakat farklı sayılarda subkonjonktival 5-FU enjeksiyonları uygulandı. Tedavi etkinliği değerlendirildi.Bulgular: idi. Ortalama GİB tedaviyle 17.07±7.10 mmHg'ya düştü. Enjeksiyonlar öncesi ve sonrası dönem arasında GİB seviyelerinde istatistiksel olarak anlamlı düşüş tespit edildi (p<0.05). Sonuç: 5-FU enjeksiyon tedavisi, trabekülektomi sonrası bleb yetmezliği olan vakalarda güvenli ve efektiftir.Anahtar Sözcükler: Trabekülektomi, bleb yetersizliği,

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Ten-year outcomes of cataract surgery for glaucoma management in patients with primary angle-closure disease

et al. 2022

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Optic Disc and Visual Field Changes after Trabeculectomy

Cited by 31 publications

References 39 publications

Short-term changes in the optic nerve head and visual field after trabeculectomy

Short-term changes in the optic nerve head and visual field after trabeculectomy

Bleb yetersizliğinin tedavisinde subkonjonktival 5-fluorourasil kullanımının sonuçları: Olgu serisi

Ten-year outcomes of cataract surgery for glaucoma management in patients with primary angle-closure disease

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