Optic Disc - Fovea Angle: The Beijing Eye Study 2011

Jonas, Rahul A.; Wang, Ya Xing; Yang, Hua; Li, Jian Jun; Xu, Liang; Panda‐Jonas, Songhomitra; Jonas, Jost B.

doi:10.1371/journal.pone.0141771

Cited by 60 publications

(56 citation statements)

References 32 publications

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“…This is the first study to investigate the relationship between the ppCT and the PMP angle. Jonas et al reported that the distance between the optic disc and fovea was shorter when the fovea was located below the horizontal line [34]. This is consistent with the present finding that the ppCT is thicker in eyes in which the fovea is located inferior to the horizontal line.…”

Section: Discussionsupporting

confidence: 92%

Correlations between local peripapillary choroidal thickness and axial length, optic disc tilt, and papillo-macular position in young healthy eyes

et al. 2017

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Optical coherence tomography (OCT) has made it possible for clinicians to measure the peripapillary choroidal thickness (ppCT) noninvasively in various ocular diseases. However, the ocular factors associated with the ppCT have not been conclusively determined. The purpose of this study was to determine the relationship between the local ppCT and the axial length, optic disc tilt, and the angle of the papillo-macular position (PMP) in healthy eyes. This was a prospective, observational cross-sectional study of 119 right eyes of 119 healthy Japanese volunteers. The ppCT was manually measured at eight sectors around the optic disc using the B-scan images of the Topcon 3D OCT RNFL 3.4 mm circle scan. The trajectory of the retinal pigment epithelium in the B-scan image was fitted to a sine curve using ImageJ, and the amplitude of the sine curve was used to determine the degree of the optic disc tilt. The PMP angle was determined in the color fundus photographs. The relationships between the ppCT and the axial length, the optic disc tilt, and PMP angle were determined by Spearman and multiple correlation analyses. The mean age was 25.8 ± 3.9 years and the mean axial length was 25.5 ± 1.4 mm. The ppCT was significantly and negatively associated with the axial length (R = -0.43 to -0.24, P<0.01) and positively associated with the PMP angle (R = 0.28 to 0.37, P<0.01) in all eight circumpapillary sectors. The temporal and infratemporal ppCTs were significantly and negatively associated with the optic disc tilt (R = -0.31, -0.20, P<0.05). The results of multiple regression analyses were similar to that of Spearman correlation analysis. In conclusion, the axial length and PMP angle can affect the ppCT in all circumferential sectors, however the tilt of the optic disc is correlated with only some of the sectors. This should be remembered in interpreting the ppCT.

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Section: Discussionsupporting

confidence: 92%

Correlations between local peripapillary choroidal thickness and axial length, optic disc tilt, and papillo-macular position in young healthy eyes

et al. 2017

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“…In the MAIA-2 microperimeter the optic disc center is identified by the clinician at the start of the test and its position is recorded in the output data. Clearly, this method is subject to population variation in relative foveaoptic disc position [23][24][25] and additional variation from the selection of the optic disc center by the clinician. Both types of variation are taken into account in our data, which suggests that using this specific measurement method the distribution of optic disc position is (15.54 6 1.058, 2.12 6 0.858 [mean 6 SD in right eye format]) relative to the fovea.…”

Section: Discussionmentioning

confidence: 99%

Spatial Interpolation Enables Normative Data Comparison in Gaze-Contingent Microperimetry

Denniss

Astle

2016

Invest. Ophthalmol. Vis. Sci.

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PURPOSE. To demonstrate methods that enable visual field sensitivities to be compared with normative data without restriction to a fixed test pattern.METHODS. Healthy participants (n ¼ 60, age 19-50) undertook microperimetry (MAIA-2) using 237 spatially dense locations up to 138 eccentricity. Surfaces were fit to the mean, variance, and 5th percentile sensitivities. Goodness-of-fit was assessed by refitting the surfaces 1000 times to the dataset and comparing estimated and measured sensitivities at 50 randomly excluded locations. A leave-one-out method was used to compare individual data with the 5th percentile surface. We also considered cases with unknown fovea location by adding error sampled from the distribution of relative fovea-optic disc positions to the test locations and comparing shifted data to the fixed surface.RESULTS. Root mean square (RMS) difference between estimated and measured sensitivities were less than 0.5 dB and less than 1.0 dB for the mean and 5th percentile surfaces, respectively. Root mean square differences were greater for the variance surface, median 1.4 dB, range 0.8 to 2.7 dB. Across all participants 3.9% (interquartile range, 1.8-8.9%) of sensitivities fell beneath the 5th percentile surface, close to the expected 5%. Positional error added to the test grid altered the number of locations falling beneath the 5th percentile surface by less than 1.3% in 95% of participants.CONCLUSIONS. Spatial interpolation of normative data enables comparison of sensitivity measurements from varied visual field locations. Conventional indices and probability maps familiar from standard automated perimetry can be produced. These methods may enhance the clinical use of microperimetry, especially in cases of nonfoveal fixation.

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“…Furthermore, the mean optic disc-fovea angle delimitating superior and inferior nerve fiber layers, is approximately 88. 45 Thus, the exact distribution of nerve fiber layers of the retina that decussates to the contralateral optic tract or remains on the ipsilateral optic tract and finally leads to a vertical delimitation through the fovea on the hemivisual field test remains unclear. Hence, in our study, the corresponding optic radiations in the homo-or contralateral side could not be accurately matched to specific sectors of the retina or the optic nerve head.…”

Section: Optic Radiations Microstructural Changes In Glaucomamentioning

confidence: 99%

Optic Radiations Microstructural Changes in Glaucoma and Association With Severity: A Study Using 3Tesla-Magnetic Resonance Diffusion Tensor Imaging

Tellouck

Durieux

Coupé

et al. 2016

Invest. Ophthalmol. Vis. Sci.

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Citation: Tellouck L, Durieux M, Coupé P, et al. Optic radiations microstructural changes in glaucoma and association with severity: a study using 3Tesla-magnetic resonance diffusion tensor imaging. Invest Ophthalmol Vis Sci. 2016;57:6539-6547. DOI:10.1167/iovs.16-19838 PURPOSE. To compare microstructural changes along the optical radiations and brain structure volumes between glaucoma and control subjects using in vivo magnetic resonance imaging and to analyze their association with severity of the disease. METHODS.A total of 50 open-angle glaucoma subjects and 50 healthy age-and sex-matched controls underwent detailed ophthalmologic examinations (including visual field testing [VF], funduscopy, and spectral-domain optical coherence tomography) as well as diffusion tensor imaging (DTI) using 3.0-Tesla magnetic resonance imaging. Fractional anisotropy (FA), mean diffusivity, radial diffusivity (RD), and axial diffusivity (AD) were quantified semiautomatically along the optical radiations. DTI parameters and volumes of specific brain structures were compared between cases and controls using conditional logistic regression. Association between DTI metrics and the severity of the disease was studied using linear mixed regression analyses. RESULTS.In glaucoma subjects, optic radiations FA was significantly lower (0.57 vs. 0.59; P ¼ 0.02) and RD was significantly higher (52.78 10 -5 mm 2 /s vs. 49.74 10 -5 mm 2 /s; P ¼ 0.03) than in controls. Optic radiations FA was significantly correlated with homolateral functional and structural damage of glaucoma (mean deviation of VF [P ¼ 0.03], retinal nerve fiber layer thickness [P ¼ 0.03], vertical cup to disc ratio [P ¼ 0.0007]). Volume and DTI parameters of other brain structures (including hippocampus) were not significantly different between glaucoma patients and controls.CONCLUSIONS. We evidenced microstructural modifications along visual pathways of glaucoma patients and these alterations were correlated with disease severity. The association of glaucoma with other neurodegenerative alterations would need further exploration and a prospective follow-up of our cohort of subjects. (ClinicalTrials.gov number, NCT01621841).

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Optic Disc - Fovea Angle: The Beijing Eye Study 2011

Cited by 60 publications

References 32 publications

Correlations between local peripapillary choroidal thickness and axial length, optic disc tilt, and papillo-macular position in young healthy eyes

Correlations between local peripapillary choroidal thickness and axial length, optic disc tilt, and papillo-macular position in young healthy eyes

Spatial Interpolation Enables Normative Data Comparison in Gaze-Contingent Microperimetry

Optic Radiations Microstructural Changes in Glaucoma and Association With Severity: A Study Using 3Tesla-Magnetic Resonance Diffusion Tensor Imaging

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