Optic Disc Pit Maculopathy Recurring in the Absence of Vitreous Gel

Coca, Mircea N.; Tofigh, Sohrab; Elkeeb, Ahmed; Godley, Bernard F.

doi:10.1001/jamaophthalmol.2014.2054

Cited by 7 publications

(5 citation statements)

References 5 publications

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“…The retinal schisis was resolved after PPV with the removal of both membranes, as shown in also a previously reported case [ 18 ]. In some patients with ODP maculopathy, actually, the retinal schisis did not improve or recur despite the PPV with only the removal of hyaloid membrane and/or ILM [ 9 , 13 , 14 ]. It is known that eyes with cavitary optic disc anomalies including ODP and glaucoma have congenital or acquired anatomical vulnerability at the optic disc in common [ 1 , 2 , 24 ].…”

Section: Discussionmentioning

confidence: 99%

“…These observations suggest that a certain communication between the retinal schisis and the vitreous cavity or subarachnoid space arose by which the posterior hyaloid membrane drew the vulnerable disc tissue [ 1 , 12 ]. However, there were cases with no improvement or showing recurrence of the retinal schisis, even after PVD was made following PPV [ 9 , 13 , 14 ]. In case series with a long-term follow-up, a foveal reattachment rate after PPV with induction of PVD was 81% and internal limiting membrane (ILM) peeling was not associated with foveal reattachment [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

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Role of the Epipapillary Membrane in Maculopathy Associated with Cavitary Optic Disc Anomalies: Morphology, Surgical Outcomes, and Histopathology

Tanaka

Saito

Kase

et al. 2018

Journal of Ophthalmology

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Purpose To evaluate the surgical outcomes of pars plana vitrectomy (PPV) with epipapillary membrane removal in patients with maculopathy associated with cavitary optic disc anomalies. Methods Eight patients (8 eyes) with cavitary optic disc anomaly-associated maculopathy who underwent PPV with epipapillary membrane removal were retrospectively reviewed. The best-corrected visual acuity (BCVA) and macular and papillary morphologies using enhanced depth imaging optical coherence tomography (EDI-OCT) were evaluated before and after treatment. Immunohistochemistry for an intraoperatively excised epipapillary membrane tissue was also performed. Results Before surgery, EDI-OCT revealed that epipapillary membrane was observed in all patients. Retinoschisis was resolved with no recurrence in all patients following vitrectomy regardless of a disease type or the presence or absence of preoperative posterior vitreous detachment. The mean final BCVA and central retinal thickness significantly improved compared with pretreatment values (P = 0.008 and 0.004, resp.). Immunoreactivity for S100 protein and glial fibrillary acidic protein, markers of astrocytes, was positive in the resected membrane tissues. Conclusions These results suggest that epipapillary membrane is involved in the pathogenesis of some patients with cavitary optic disc anomaly-associated maculopathy as well as posterior hyaloid membrane. PPV with epipapillary membrane removal may be a useful treatment option for this maculopathy. This trial is registered with UMIN000011123.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Role of the Epipapillary Membrane in Maculopathy Associated with Cavitary Optic Disc Anomalies: Morphology, Surgical Outcomes, and Histopathology

Tanaka

Saito

Kase

et al. 2018

Journal of Ophthalmology

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“…Coca et al [14] reported a case of ODP-M that recurred 16 years after vitrectomy, and they suggested that vitreous traction did not cause the recurrent maculopathy. We suppose that the complete removal of vitreous traction is an unreliable method to cure ODP-M in not only recurrent cases but also primary cases.…”

Section: Discussionmentioning

confidence: 99%

Refined Internal Limiting Membrane Inverted Flap Technique for Intractable Macular Detachment with Optic Disc Pit

Hara

Tsukahara

Simoyama

et al. 2017

Case Rep Ophthalmol

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Purpose: To report a surgical technique for retinal detachment associated with optic disc pit (ODP) by using an internal limiting membrane (ILM) inverted flap as an obstacle between the vitreous cavity and subretinal space. Case Presentation: A 43-year-old man presented with decreased visual acuity in the right eye for 1 week due to macular detachment associated with ODP. After 2 unsuccessful surgeries, the retina was reattached by vitrectomy with an ILM inverted flap onto the ODP. Conclusion: Covering the pit with an inverted ILM flap is a reliable method for intercepting fluid from the vitreous cavity. Immediate absorption of subretinal fluid may lead to early macular attachment. This technique would be effective in managing ODP.

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“…It is noteworthy that two eyes had late recurrences of the serous detachment more than a year after the initial successful PPV surgery. Even though fluctuating course of the disease has been reported, with ODP-M healing spontaneously (Bloch et al 2019) and after PVD (Bonnet 1991;Gupta & Choudhry 2016) as well as reappearance of a macular detachment long after successful surgery (Coca et al 2014), it is not unlikely that all cases of recurrences and inadequate healing were associated with retinotomies. Our interpretation is that drainage of SRF does not clearly contribute to healing of the condition but could rather be the cause of unnecessary complications and should probably be avoided.…”

Section: Discussionmentioning

confidence: 99%

A prospective long‐term follow‐up study of optic disc pit maculopathy treated with pars plana vitrectomy, drainage of subretinal fluid and peeling of internal limiting membrane

Makdoumi

Crafoord

2020

Acta Ophthalmologica

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Purpose To describe the long‐term results of surgical repair of patients with optic disc pit maculopathy (ODP‐M). Methods Prospective, consecutive, noncomparative follow‐up study including 12 patients with ODP‐M treated by pars plana vitrectomy (PPV), peeling of internal limiting membrane followed by gas tamponade. Subretinal fluid (SRF) was drained in 11 eyes through a retinotomy without laser photocoagulation. Preoperatively, macular detachment with retinoschisis was seen in 9 out of 12 eyes with three eyes having only subretinal fluid in the macular area. The median age at surgery was 20 years (range 9–60 years). Results Follow‐up time from initial surgery was 63 months (median). Eight eyes were anatomically reattached after one operation without remaining SRF in the macula. Two patients required a reoperation due to leakage from the retinotomy and another two underwent a second PPV procedure due to late recurrences. Successful healing was at follow‐up control observed in 11 of 12 eyes. There was no statistically significant difference in visual acuity between patients before and after surgery (p = 0.24). Central visual field defects with depressed mean deviation were detected in all treated eyes. Conclusion In this long‐term study of ODP‐M final outcome regarding healing was relatively efficacious, however, a relatively large proportion had complications associated to retinotomies. We conclude that drainage of SRF should likely be avoided since it appears to contribute little to the resorption rate of SRF and seems to linked to unnecessary risks.

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Optic Disc Pit Maculopathy Recurring in the Absence of Vitreous Gel

Cited by 7 publications

References 5 publications

Role of the Epipapillary Membrane in Maculopathy Associated with Cavitary Optic Disc Anomalies: Morphology, Surgical Outcomes, and Histopathology

Role of the Epipapillary Membrane in Maculopathy Associated with Cavitary Optic Disc Anomalies: Morphology, Surgical Outcomes, and Histopathology

Refined Internal Limiting Membrane Inverted Flap Technique for Intractable Macular Detachment with Optic Disc Pit

A prospective long‐term follow‐up study of optic disc pit maculopathy treated with pars plana vitrectomy, drainage of subretinal fluid and peeling of internal limiting membrane

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