Optic Nerve

Yanoff, Myron

doi:10.1016/b978-1-4557-2874-9.00013-2

Cited by 9 publications

(9 citation statements)

References 146 publications

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“…To evaluate distortions in SF and UWF imaging, the diameter of the optic disc was assumed to equal 1.5 mm (Yanoff & Sassani ) (Fig. A,D) and this was used to calibrate measurements.…”

Section: Methodsmentioning

confidence: 99%

Ultra‐widefield fundus photography for radiation therapy planning of ocular tumours

Mathis

Espensen

Caujolle

et al. 2019

Acta Ophthalmologica

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Purpose The use of planar ultra‐widefield fundus photography (UWF) may result in distortions and inaccurate measurement. The aim of the study was to evaluate the accuracy of UWF instead of the standard narrow field (SF) for the treatment planning phase of ocular tumours. Methods Distortions between conformal SF and UWF were assessed in 43 patients with choroidal melanoma treated with either proton therapy or brachytherapy. imagej software was used to measure distortion. Results The median interquartile range ([IQR]) distortion for all cases was 3.7% [1.7–10.8]. For cases with tumours within 6 mm of the optic disc, distortions appeared clinically nonsignificant. For peripheral and/or large tumours, significantly larger distortions were observed on UWF (median 4.4% [2.7–22.6] for tumours ≥6 mm from the optic disc versus 3.3% [1.6–9.9] for those <6 mm, p = 0.04). Images can be subdivided into three groups: minimal distortion (79.1% of eyes), similar level of major distortion for both measured distances (11.6%) and distortion with unequal level of distortion between the measured distances (9.3%). Conclusion Distortions with UWF appeared minimal in posterior regions of the fundus and increased with the distance from the posterior pole. UWF could therefore be used for treatment planning of ocular tumours as the planned radiation dose to the macula and optic disc are not impacted.

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“…To evaluate distortions in SF and UWF imaging, the diameter of the optic disc was assumed to equal 1.5 mm (Yanoff & Sassani ) (Fig. A,D) and this was used to calibrate measurements.…”

Section: Methodsmentioning

confidence: 99%

Ultra‐widefield fundus photography for radiation therapy planning of ocular tumours

Mathis

Espensen

Caujolle

et al. 2019

Acta Ophthalmologica

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“…Furthermore, the optic foramen may still be of normal diameter in the sitting of intracranial or chiasmal ONG [80]. Histopathologic examination performed on a resected ONG, which did not reveal spread intracranially by MRI as well as by gross examination, showed an evidence of intracranial spread [81].…”

Section: Primary Tumors Of the Optic Nerve 41 Optic Pathway Glioma mentioning

confidence: 97%

Optic Nerve: Developmental Anomalies and Common Tumors

Alkatan¹,

Alshowaeir²,

Alzahem³

2019

Optic Nerve

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The optic nerve, also known as the second cranial nerve, is composed of axons that transmit visual information from the neurosensory retina to the visual cortex. There are multiple pathologies that can affect the human optic nerve. Congenital anomalies of the optic nerve include myelinated nerve fibers, morning glory syndrome, optic nerve choristoma, optic nerve coloboma, optic nerve hypoplasia and aplasia, and others. Tumors that can affect the optic nerve (ON) may occur primarily from within the nerve itself, from the surrounding optic nerve sheath (ONS), or secondarily spreading to the nerve from a distant site. They include optic pathway glioma, medulloepithelioma, oligodendroglioma, optic nerve sheath meningioma, and others. Here in this chapter, we will review the optic nerve anatomy, embryology, and physiology in addition to assessment of optic nerve function. Moreover, the clinical features, imaging findings, pathology, and treatment options of the most common and some rare congenital anomalies and primary tumors of the ON and sheath will be reviewed.

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“…The optic nerve is a white matter tract that is formed by retinal ganglion cell axons in the retina, conveying visual information to the brain. [94] The proteome of the optic nerve is of particular interest due to its role in common diseases such as glaucoma and optic neuritis. Prior to 2013, the proteome of the optic nerve was not well characterized, with one study showing elevated peptidyl arginine deiminase 2 and citrillunated myelin basic protein in primary open angle glaucoma.…”

Section: Proteomes Of Human Eye Tissues and Fluidsmentioning

confidence: 99%

The Human Eye Proteome Project: Updates on an Emerging Proteome

et al. 2018

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The human eye is a complex organ consisting of multiple compartments with unique and specialized properties that reflect their varied functions. Although there have been advancements in ocular imaging and therapeutics over the past decade, the pathogenesis of many common eye diseases remains poorly understood. Proteomics is an invaluable tool to gain insight into pathogenesis, diagnosis, and treatment of eye diseases. By 2013, when the Human Eye Proteome Project (also known as the EyeOme) was founded, there were 4842 nonredundant proteins identified in the human eye. Twenty-three recent papers on the human eye proteome were identified in PubMed searches. These papers were used to compile an updated resource of 9782 nonredundant proteins in the human eye. This updated catalogue sheds light on the molecular makeup of previously undescribed proteomes within the human eye, including optic nerve, sclera, iris, and ciliary body, while adding additional proteins to previously characterized proteomes such as aqueous humor, lens, vitreous, retina, and retinal pigment epithelium/choroid. Although considerable advances have been made to characterize the complete proteome of the human eye, additional high-quality data are needed to confirm and quantify previously discovered eye proteins in both health and disease.

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Optic Nerve

Cited by 9 publications

References 146 publications

Ultra‐widefield fundus photography for radiation therapy planning of ocular tumours

Ultra‐widefield fundus photography for radiation therapy planning of ocular tumours

Optic Nerve: Developmental Anomalies and Common Tumors

The Human Eye Proteome Project: Updates on an Emerging Proteome

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