Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis

Kolbe, Scott; Chapman, Caron; Nguyen, Thanh Binh; Bajraszewski, Clare; Johnston, Leigh A.; Kean, Michael; Mitchell, Peter; Paine, Mark; Butzkueven, Helmut; Kilpatrick, Trevor J.; Egan, Gary F.

doi:10.1016/j.neuroimage.2008.12.047

Cited by 89 publications

(97 citation statements)

References 41 publications

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“…Although there is evidence of more pronounced DTI alterations within ON-affected optic nerves compared to DTI value changes in MS fellow eyes without prior ON [113], this notion has been questioned by an investigation of a large cohort (104 MS patients) showing both ON-affected and non-ON-affected optic nerves to exhibit similar FA decrease with no differences between the two groups [109]. However, the same study showed correlations between FA decrease and high-contrast visual acuity (HCVA) impairment to be stronger in ON optic nerves compared to non-ON optic nerves.…”

Section: Optic Nerve Dti In Ms-onmentioning

confidence: 92%

“…These processes seem to be detectable and-at least to a certain extent-quantifiable by use of optic nerve DTI. Multifocal VEP amplitude reductions of affected optic nerves were found to be associated with decreased FA values and linear regression revealed optic nerve FA decrease to be associated with optic nerve atrophy [113]. One study reported associations between optic nerve RD increase and visual acuity decline after MS-associated ON [108].…”

Section: Optic Nerve Dti In Ms-onmentioning

confidence: 99%

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Diffusion tensor imaging for multilevel assessment of the visual pathway: possibilities for personalized outcome prediction in autoimmune disorders of the central nervous system

et al. 2017

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The afferent visual pathway represents the most frequently affected white matter pathway in multiple sclerosis (MS) and neuromyelitis optica spectrum disorders (NMOSD). Diffusion tensor imaging (DTI) can reveal microstructural or non-overt brain tissue damage and quantify pathological processes. DTI facilitates the reconstruction of major white matter fiber tracts allowing for the assessment of structure-function and damage-dysfunction relationships. In this review, we outline DTI studies investigating the afferent visual pathway in idiopathic optic neuritis (ON), NMOSD, and MS. Since MS damage patterns are believed to depend on multiple factors, i.e., ON (anterior visual pathway damage), inflammatory lesions (posterior visual pathway damage), and global diffuse inflammatory and neurodegenerative processes, comprehensive knowledge on different contributing factors using DTI in vivo may advance our understanding of MS disease pathology. Combination of DTI measures and visual outcome parameters yields the potential to improve routine clinical diagnostic procedures and may further the accuracy of individual prognosis with regard to visual function and personalized disease outcome. However, due to the inherent limitations of DTI acquisition and post-processing techniques and the so far heterogeneous and equivocal data of previous studies, evaluation of the true potential of DTI as a possible biomarker for afferent visual pathway dysfunction is still substantially limited. Further research efforts with larger longitudinal studies and standardized DTI acquisition and post-processing validation criteria are needed to overcome current DTI limitations. DTI evaluation at different levels of the visual pathway has the potential to provide markers for individual damage evaluation in the future. As an imaging biomarker, DTI may support individual outcome prediction during personalized treatment algorithms in MS and other neuroinflammatory diseases, hereby leveraging the concept of predictive, preventive, and personalized medicine in the field of clinical neuroimmunology.

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Section: Optic Nerve Dti In Ms-onmentioning

confidence: 92%

Section: Optic Nerve Dti In Ms-onmentioning

confidence: 99%

Diffusion tensor imaging for multilevel assessment of the visual pathway: possibilities for personalized outcome prediction in autoimmune disorders of the central nervous system

et al. 2017

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“…77,97,[99][100][101][102] Atrophy is detectable in the optic nerve 91,96,103 and dynamic changes in MRI diffusion parameters occur, which reflect changes in myelin and axonal damage. [104][105][106][107] Neuroaxonal loss occurs in the retinal nerve fiber layer and macula. 97,98,103 Despite this, most patients make a good clinical recovery, which may reflect neuroaxonal redundancy, 108 or an influence of repair mechanisms, such as remyelination 78,109,110 or adaptive changes in the gray matter, known as neuroplasticity.…”

Section: Investigating Damage and Recovery In Onmentioning

confidence: 99%

New developments in the treatment of optic neuritis

Jenkins

Toosy

2010

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Acute optic neuritis (ON) has various etiologies. The most common presentation is inflammatory, demyelinating, idiopathic, or "typical" ON, which may be associated with multiple sclerosis. This must be differentiated from "atypical" causes of ON, which differ in their clinical presentation, natural history, management, and prognosis. Clinical "red flags" for an atypical cause of ON include absent or persistent pain, exudates and hemorrhages on fundoscopy, very severe, bilateral, or progressive visual loss, and failure to recover. In typical ON, steroids shorten the duration of the attack, but do not influence visual outcome. This is in contrast to atypical ON associated with conditions such as sarcoidosis and neuromyelitis optica, which require aggressive immunosuppression and sometimes plasma exchange. The visual prognosis of typical ON is generally good. The prognosis in atypical ON is more variable. New developments aimed at designing better treatments for patients who fail to recover are discussed, focusing on recent research elucidating mechanisms of damage and recovery in ON. Future therapeutic directions may include enhancing repair processes, such as remyelination or adaptive neuroplasticity, or alternative methods of immunomodulation. Pilot studies investigating the safety and proof-ofprinciple of stem cell treatment are currently underway.

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“…Verification of the visual pathway lesion is particularly important in the absence of changes in the fundus in patients with retrobulbar neuritis and early stages of inflammation of the optic nerve [8][9][10][11][12][13][14]. Despite the large number of articles devoted to this issue, the dynamics of changes in VEPs in ON are still under discussion.…”

Section: Introductionmentioning

confidence: 99%

Diagnostic Value of the Visual Evoked Potential Investigation in Optic Neuritis

Хамраева¹,

Kamilov²,

Kasimova³

2015

Int J Biomed

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Objective: Comparative analysis of the results of the visual evoked potential investigation according to stages of optic neuritis (ON).Material and Methods: The study included 90 patients (90 eyes) with different stages of ON. A control group comprised 10 somatically healthy persons (10 eyes) of the same age without ophthalmic pathology. All examined underwent standard ophthalmologic examination, including visometry, tonometry, perimetry, and ophthalmoscopy, as well as optical coherence tomography (OCT) and visual evoked potentials (VEP) determination.Results: The VEP parameters provide identification of the functional disorders of the optic nerve. Our results showed that there is delayed latency and reduced amplitude of the P100 component in patients with ischemic and atrophic stages of the disease. In ON, P100 was the most informative index. We noted that the N145 parameter in ON is not very informative.

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Optic nerve diffusion changes and atrophy jointly predict visual dysfunction after optic neuritis

Cited by 89 publications

References 41 publications

Diffusion tensor imaging for multilevel assessment of the visual pathway: possibilities for personalized outcome prediction in autoimmune disorders of the central nervous system

Diffusion tensor imaging for multilevel assessment of the visual pathway: possibilities for personalized outcome prediction in autoimmune disorders of the central nervous system

New developments in the treatment of optic neuritis

Diagnostic Value of the Visual Evoked Potential Investigation in Optic Neuritis

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