Optic nerve oxygenation

Stefánsson, Einar; Pedersen, Daniella Bach; Jensen, Patricia; Cour, Morten la; Kiilgaard, Jens Folke; Bang, K; Eysteinsson, Þór

doi:10.1016/j.preteyeres.2004.09.001

Cited by 76 publications

(61 citation statements)

References 113 publications

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“…It is hypothesised that hypoxia and hypercapnia lead to damage of the optic nerve. 27 Narkiewicz and Somers reported that hypercapnia is circumvented during sleep because chemoreceptor sensitivity is decreased nocturnally, 28 and hypoxia, detected by carotid chemoreceptors, leads to an increase in blood pressure. Additionally, Berry and Gleeson and Smith et al reported a sympathetic activation after inspiratory effect, sleep arousal, and sleep disturbance.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Thickening in Patients with Sleep Apnea Syndrome

Ekinci¹,

Huseyinoglu²,

Çağatay³

et al. 2014

Neuro-Ophthalmology

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Sleep apnoea syndrome (SAS) is characterised by repetitive episodes of cessation of breathing during sleep, resulting in hypoxaemia and hypercapnia. Ophthalmological consequences such as glaucoma, non-arteritic anterior ischaemic neuropathy and papilloedema are relevant to hypoxaemia. The choroid is a vascular structure that performs several regulatory functions for the retina. Defects in this structure contribute to degenerative, inflammatory, and neovascular changes in the retina. The authors examined the choroidal thickness (CT) in sleep apnoea patients using optical coherence tomograpy (OCT). The sleep apnoea patients were divided into subgroups according to their apnoea-hypopnoea index (AHI) scores, and statistical analysis was performed using the AHI and minimal arterial oxygen saturation (min. SpO 2 ) values. There was a mediumhigh negative correlation between CT and AHI (Spearman rho: r = À0.744, p = 0.000), and a positive correlation between CT and min. SpO 2 values (Pearson correlation: r = 0.308, p = 0.000).

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Section: Discussionmentioning

confidence: 99%

Choroidal Thickening in Patients with Sleep Apnea Syndrome

Ekinci¹,

Huseyinoglu²,

Çağatay³

et al. 2014

Neuro-Ophthalmology

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show abstract

“…When OPP varies secondary to blood flow changes, the ability of the eye to buffer against changes in perfusion pressure (autoregulation) increases the risk of impaired metabolic supply (reduced oxygen and nutrients) 22 thus causing neuronal dysfunction.…”

Section: Discussionmentioning

confidence: 99%

A comparative study of intraocular pressure changes in postmenopausal normotensive and hypertensive women

et al. 2014

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“…ROCK inhibitors increase blood flow under systemic hypertensive conditions via relaxation of vascular endothelial smooth muscle. As altered ocular blood flow is believed to be key to the pathophysiology of certain types of glaucoma (44) , ROCK inhibitors could provide additional benefit as therapeutics agents for glaucoma.…”

Section: Other Applications Of Rock Inhibitorsmentioning

confidence: 99%