Optic neuritis following anti-rabies vaccine

Agarwal, Ayush; Garg, Divyani; Goyal, Vinay; Pandit, Awadh Kishor; Srivastava, Achal; Srivastava, MV Padma

doi:10.1177/0049475519872370

Cited by 11 publications

(6 citation statements)

References 6 publications

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“…The COVID vaccine, like any other, can cause side effects including mostly low-grade fever or muscle aches, and rarely neurological events [10]. Ocular side-effects caused by vaccinations are widely studied in existing literature [11][12][13][14][15], and occurrence of facial nerve palsies [16], abducens nerve palsy [17], acute macular neuropathy [18][19][20], central serous retinopathy [21], thrombosis [22], uveitis [23,24], multiple evanescent white dot syndrome (MEWDS) [25], Vogt-Koyanagi-Harada (VKH) reactivation [26] and Grave's disease [27] has been documented after administration of the COVID-19 vaccination. As early as 2 weeks following administration of the inactivated COVID-19 vaccination, 12 eyes of 9 patients suffered from various ocular conditions such as choroiditis, uveitis, keratitis, scleritis, acute retinal necrosis, and iridocyclitis as reported by Kunpeng et al [28] Predominantly retinal adverse events, namely paracentral acute middle maculopathy (PAMM), acute macular neuropathy (AMN), and subretinal fluid were reported by Pichi et al, after Sinopharm COVID-19 vaccination in 7 patients [29].…”

Section: Discussionmentioning

confidence: 99%

Optic Neuritis Following COVID-19 Vaccination: Real-World Ophthalmic Presentation

Roy¹,

Shrotriya²

2023

COVID-19 Vaccines - Current State and Perspectives

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After being plagued by COVID-19 for nearly 2 years, the whole world wishes for little more than the complete eradication of the disease. Our country, India commenced the much-awaited vaccination drive in Jan 2021. Ophthalmic manifestations have appeared in many forms post-COVID, amongst which neuro-ophthalmic manifestations are infrequent. This is a short series of three cases that presented with optic neuritis (ON). On further inquiry, all had received the Covishield vaccine within 5–12 days before the presentation, with no history of COVID-positive RT-PCR. All patients improved after pulse steroid therapy and are still under follow-up. Nevertheless, it’s hard to determine whether post-COVD vaccine ON is a coincidence or cause. This series highlights the importance of taking the history of recent vaccination, especially in patients presenting with ON in the COVID 19 pandemic era.

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Section: Discussionmentioning

confidence: 99%

Optic Neuritis Following COVID-19 Vaccination: Real-World Ophthalmic Presentation

Roy¹,

Shrotriya²

2023

COVID-19 Vaccines - Current State and Perspectives

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“…10 Flu vaccination has also been reported to be associated with numerous ophthalmic adverse effects; in addition to uveitis, 10 multiple evanescent white dot syndrome 14 and a variety of types of inflammation involving the optic nerve, including optic nerve head inflammation, 15 retrobulbar optic nerve inflammation, 16 and acute macular neuroretinopathy 17 have been documented. Optic neuritis has also been reported to be associated with administration of the tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap)-inactivated polio vaccine, 18 hepatitis A virus (HAV) vaccine and typhoid fever vaccine, 19 measles vaccine, 20 anti-rabies vaccine, 21 , 22 Tdap vaccine, 23 and varicella-zoster virus vaccine. 24 Although the exact mechanism is unknown, vaccine-induced optic neuritis is believed to occur because the T-cells activated by vaccines cross the blood-brain barrier, resulting in type IV hypersensitivity.…”

Section: Discussionmentioning

confidence: 99%

Neuroretinitis after the second injection of a SARS-CoV-2-vaccine: A case report

Lee

Park

Ham

et al. 2022

American Journal of Ophthalmology Case Reports

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“…Cases of ON have also been reported following vaccination including rabies and influenza vaccines; however, no large cohort studies have been published on this topic 2 3…”

Section: Introductionmentioning

confidence: 99%

Systematic review exploring the clinical features of optic neuritis after SARS-CoV infection and vaccination

Georganta,

Chasapi,

Smith

et al. 2023

BMJ Open Ophth

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BackgroundThis study aims to characterise the symptoms and clinical features of optic neuritis (ON) following SARS-CoV-2 infection and vaccination.MethodA literature search was conducted in four databases (PubMed, Medline, Embase and Google Scholar) to identify relevant case reports and case series. The records were screened and articles adhering to the inclusion criteria were critically appraised.ResultsSixty-eight studies were found to be eligible for inclusion, including 34 reporting ON following SARS-CoV-2 infection and an equal number reporting cases postvaccination. In total 93 patients and 125 eyes were included. The infection cohort included 42 patients and 56 eyes, 51.2% were female and 33.3% experienced bilateral ON. The mean visual acuity was 1.64 log of minimum angle of resolution (LogMAR), while pain was present in 77.8%. Oligoclonal bands were present in 3 patients, myelin oligodendrocyte glycoprotein (MOG) antibodies in 18 patients and AQP-4 antibodies in 4 patients. The vaccination cohort included 51 patients and 69 eyes. 60.8% were female and 35.3% had a bilateral ON. The mean visual acuity was 0.93 LogMAR. Oligoclonal bands were present in 46.7%, MOG antibodies in nine patients and AQP-4 antibodies in three patients.ConclusionPatients with ON post-SARS-CoV infection were more likely to experience severe visual impairment than in cases following vaccination. Further research is required to outline the clinical features of ON after COVID-19 infection and vaccination, and establish causality.

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Optic neuritis following anti-rabies vaccine

Cited by 11 publications

References 6 publications

Optic Neuritis Following COVID-19 Vaccination: Real-World Ophthalmic Presentation

Optic Neuritis Following COVID-19 Vaccination: Real-World Ophthalmic Presentation

Neuroretinitis after the second injection of a SARS-CoV-2-vaccine: A case report

Systematic review exploring the clinical features of optic neuritis after SARS-CoV infection and vaccination

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