Optic neuritis in children: Clinical features and visual outcome

Brady, K.; Brar, A. S.; Lee, Andrew G.; Coats, David K.; Paysse, Evelyn A.; Steinkuller, Paul G.

doi:10.1016/s1091-8531(99)70078-9

Cited by 83 publications

(68 citation statements)

References 16 publications

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“…For instance, unilateral involvement, 9 normal MRI of the brain, and children 6 years of age or younger appeared to have a better visual prognosis. 8 Compared with a previous study, there was no significant difference in visual outcome between children with unilateral involvement and bilateral involvement in our study. Although we also found a trend toward children with normal image study seeming to have a better visual outcome, there was no statistically significant difference.…”

Section: Discussioncontrasting

confidence: 89%

“…Our finding was compatible with the observation from previous reports. 8,31 In this study, all these three patients with MS had bilateral optic neuritis, indicating that a bilateral disease might be a risk factor for developing MS.…”

Section: Discussionmentioning

confidence: 50%

“…8,11,12,14,15,17,19 According to these reports, 77-90% of patients attained final VA of 20/40 or better. In addition, optic neuritis in childhood had more bilateral, female involvement, disc swelling at presentation, and was frequently associated with preceding viral infection.…”

Section: Discussionmentioning

confidence: 98%

“…Children with optic neuritis usually experience better visual recovery, they also have more bilateral involvement and optic disc swelling, and carry a relatively low risk of subsequent MS as well. [8][9][10] However, there have been accumulating reports with different clinical characteristics of optic neuritis and MS in Europe, 11,12 North America, 8,9,13 and Asia. [14][15][16][17] Herein we report a retrospective study to evaluate the clinical characteristics of children with optic neuritis in Taiwan.…”

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics of optic neuritis in Taiwanese children

Sun

et al. 2011

Eye

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Section: Discussioncontrasting

confidence: 89%

Section: Discussionmentioning

confidence: 50%

Section: Discussionmentioning

confidence: 98%

Section: Introductionmentioning

confidence: 99%

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Clinical characteristics of optic neuritis in Taiwanese children

Sun

et al. 2011

Eye

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“…Brady et al (70) reviram as características da neurite óptica numa série de 25 crianças (39 olhos). A idade dos pacientes variou de 21 meses a 18 anos e o tempo médio de follow-up foi 11 meses.…”

Section: Neurite óPtica Desmielinizanteunclassified

Neuro-oftalmologia: Sistema sensorial - parte I revisão 1997-1999

Lana-Peixoto

2002

Arq. Bras. Oftalmol.

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Anti–Myelin Oligodendrocyte Glycoprotein Antibodies in Pediatric Patients With Optic Neuritis

Rostásy¹,

Mader²,

Schanda³

et al. 2012

Arch Neurol

177

129

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To study the humoral immune response directed at myelin oligodendrocyte glycoprotein (MOG) in pediatric patients with isolated and recurrent optic neuritis (ON).Design: Observational prospective case series.Setting: Six pediatric hospitals in Germany and Austria.Patients: Thirty-seven patients 18 years or younger with single or recurrent episodes of ON were recruited from 6 different hospitals.Main Outcome Measures: Clinical features, magnetic resonance imaging findings, intrathecal IgG synthesis, and outcome were recorded. A live cell-based immunofluorescence assay was used to measure serum IgG antibodies to MOG and aquaporin 4.Results: A single episode of ON was observed in 10 patients, and 15 experienced 2 to 12 episodes. The acute episode of ON was part of a clinically isolated syndrome in 12 patients, of whom 8 were subsequently classified as having multiple sclerosis. High-titer serum MOG-IgG antibodies (Ն1:160) were detected in 17 patients (46%). In addition, high titers of MOG-IgG antibodies were more frequently observed in 12 of the 15 patients with recurrent episodes of ON (80%; median titer, 1:640) compared with 2 of the 10 patients with monophasic ON (20%; median titer, 0) and 3 of the 12 patients with ON as part of a clinically isolated syndrome (25%; median titer, 0). Conclusion:High-titer MOG-IgG antibodies are predominantly detected in pediatric patients with recurrent ON, indicating that anti-MOG-specific antibodies may exert a direct role in the pathogenesis of ON in this subgroup.

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Optic neuritis in children: Clinical features and visual outcome

Cited by 83 publications

References 16 publications

Clinical characteristics of optic neuritis in Taiwanese children

Clinical characteristics of optic neuritis in Taiwanese children

Neuro-oftalmologia: Sistema sensorial - parte I revisão 1997-1999

Anti–Myelin Oligodendrocyte Glycoprotein Antibodies in Pediatric Patients With Optic Neuritis

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