Optic Neuritis or Multiple Sclerosis

Kurtzke, John F.

doi:10.1001/archneur.1985.04060070098026

Cited by 74 publications

(32 citation statements)

References 27 publications

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“…The discrepancy might be due to geographical differences, ra cial predisposition, differences in diagnostic criteria for ON and MS, differences in meth ods of analysis (retrospective or prospec tive), or differences in the length of the fol low-up period. Nevertheless, our 25% rate of ON developing to MS coincided with most studies which indicate that 25-35% of pa tients with ON will develop MS [3,15,16].…”

Section: Discussionsupporting

confidence: 84%

Progression of Optic Neuritis to Multiple Sclerosis: A Prospective Study in an Italian Population

Mapelli

Pavoni²,

Palma³

et al. 1991

Neuroepidemiology

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We prospectively studied 40 patients with uncomplicated optic neuritis (ON) to determine the risk of subsequent multiple sclerosis (MS). All patients were followed for at least 12 years. Ten patients (25%) developed MS. Seven of these 10 patients developed MS within 2 years. Both sexes were at high risk if ON occurred between the ages of 21 and 40. There was an overall increased risk of MS with recurrent ON. The course of MS appeared to be fairly benign during the period of observation.

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Section: Discussionsupporting

confidence: 84%

Progression of Optic Neuritis to Multiple Sclerosis: A Prospective Study in an Italian Population

Mapelli

Pavoni²,

Palma³

et al. 1991

Neuroepidemiology

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“…10,11 In the United States of America, studies have estimated the annual incidence of ON as 5 to 6.4 per 100 000, with a prevalence of 115 per 100 000. 12,13 The demographics for ON would be expected to closely follow those seen in MS, although there is no data to support this known to the authors.…”

Section: Epidemiologymentioning

confidence: 99%

Optic neuritis

Pau

Al‐Zubidi

Yalamanchili

et al. 2011

Eye

131

115

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Aims The aim of this study is to provide a clinical update on optic neuritis (ON), its association with multiple sclerosis (MS), and neuromyelitis optica (NMO). Methods This study included a PubMed review of the literature written in the English language.Results ON in adults is typically idiopathic or demyelinating, and is characterised by unilateral, subacute, painful loss of vision that is not associated with any systemic or other neurological symptoms. Demyelinating ON is associated with MS, and we review the key studies of ON including the ON treatment trial and several other MS treatment trials and NMO. Conclusion Acute demyelinating ON can occur in isolation or be associated with MS. Typical ON does not require additional evaluation other than cranial magnetic resonance imaging. NMO is likely a separate disorder from MS and the ON in NMO has a different treatment and prognosis. Methodology The authors conducted an English language search using Pubmed from the years 1964 to 2010 using the search terms 'ON', 'MS' and 'NMO'. The authors included original articles, review articles, and case reports, which revealed new aspects as far as epidemiology, histopathology, clinical manifestations, imaging, genetics, and treatment of ON. Titles were reviewed for topicality and full references were obtained. Letters to the editor, unpublished work, and abstracts were not included in this review.

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“…Ninety percent of clinically definite MS (CDMS) patients have electrophysiological evidence of ON based on visual-evoked potentials (20). Based on several older retrospective studies, the conversion rate of ON to MS has varied widely ranging from 8 to 85% (21). The potential for conversion to MS highlights the importance of investigating ON.…”

Section: Discussionmentioning

confidence: 99%