Optic Neuropathy in Multiple Sclerosis

Gartner, Samuel

doi:10.1001/archopht.1953.00920030729007

Cited by 52 publications

(25 citation statements)

References 6 publications

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“…[33][34][35][36] In a previous study, Parisi et al 37 tried to measure the ONH changes in ON by means of Optical Coherence Tomography (OCT). The authors assessed axonal loss in RNFL after a single clinical episode of unilateral ON.…”

Section: Discussionmentioning

confidence: 99%

“…Demyelination of the optic nerve leads frequently to ganglion cell loss and subsequent nerve atrophy. 1 In the last years, many new instruments have been introduced to quantify retinal ganglion cells. 2 In particular, in glaucoma disease, loss of ganglion cells is characterized by reduction of the retinal nerve fibre layer (RNFL) outside the optic nerve head (ONH) and by the enlargement of the optic cup.…”

Section: Introductionmentioning

confidence: 99%

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Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patients

Iester

Cioli

Uccelli

et al. 2007

Eye

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Purpose To verify whether scanning laser polarimeter with the new variable corneal compensation algorithm (GDx VCC) and scanning laser ophthalmoscopy (Heidelberg Retina Tomograph (HRT)) allow measuring retinal ganglion cell loss in patients with multiple sclerosis (MS). Patients and methods We enrolled 23 MS patients with a history of previous demyelinating monocular optic neuritis. Examination included visual evoked potentials (VEPs), scanning laser ophthalmoscopy, and scanning laser polarimeter. HRT was performed to assess optic nerve head (ONH) shape, while GDx VCC was used to evaluate the retinal nerve fibre layer thickness (RNFLt) around the ONH. Statistical analysis was performed comparing results obtained for each eye with the available normative database and with the unaffected fellow eye. Results When the affected eye group was compared to the fellow-eye group, a significant (Po0.05) difference was found for few GDx VCC parameters. In contrast, no significant correlation was observed between clinical assessment and imaging techniques when the normal database of HRT and GDx VCC was used. A significant association was observed between VEP latency and some GDx VCC parameters. Conclusions Our results suggested that scanning laser polarimetry could detect loss of ganglion cells following demyelinating optic neuritis, but further studies are needed.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patients

Iester

Cioli

Uccelli

et al. 2007

Eye

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“…Compston et a1 [21 reported recurrences in 31% of their patients with O N . In our study recurrences of ON were more common; they took place in 48% of all patients and in 58% of the patients with MS. A recurrent attack strongly suggested MS. Autopsy studies in patients with MS always show plaques in the optic nerves, even if there have been no subjective symptoms during the patient's lifetime [4]. Careful examination of rapid and slow eye movements gives important information about brainstem and cerebellar functions.…”

Section: Discussionmentioning

confidence: 99%

Prognosis of optic neuritis with special reference to cerebrospinal fluid immunoglobuhs and measles virus antibodes

Nikoskelainen

Frey

Salmi

1981

Annals of Neurology

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Forty-eight patients with optic neuritis (ON), first seen in 1970 to 1973, were neurologically and neuroophthalmologically reexamined after 7 to 10 years. Twenty-seven patients (56%) had probable MS, and 9 (19%) had possible MS. During the attack of ON, the cerebrospinal fluid (CSF) samples and serum/CSF measles antibody ratios were studied. Twenty patients had increased relative immunoglobulin G (IgG) (% of total protein) in their CSF; 19 of these had probable or possible MS. However, 17 of 28 patients with a normal relative IgG value had also developed MS. CSF electrophoresis was abnormal in 20 patients with ON; reexamination showed that 19 had probable or possible MS. Sixteen of 27 patients with normal electrophoresis had also developed MS. Serum/CSF measles antibody ratio had decreased in 19 patients; 13 of these had probable MS and 3 had possible MS. Of 29 patients with a normal measles antibody ratio, 14 had probable MS and 6 had possible MS. The conclusion is that examination of the CSF in ON gives valuable prognostic information because increased relative IgG, abnormal electrophoresis, or a decreased measles antibody ratio implies a high risk of developing MS. A normal CSF does not, however, rule out the possibility of dissemination.

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“…The peak latencies were 57. 6 neuritis, 56.3 _ 1.5msec in the MS cases without optic neuritis, and 56.7 -t-0.67msec (SE) in normal subjects. No significant difference was found among the peak latencies of the three groups.…”

Section: Electrophysiological Studiesmentioning

confidence: 89%

Facially distributed pattern-evoked potentials in multiple sclerosis

Adachi-Usami

1987

Doc Ophthalmol

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Among 56 established cases of multiple sclerosis in our clinic from April 1978 to March 1985, optic neuritis was found in 38; 21 cases were bilateral. We studied pattern-evoked potentials detected with 16 electrodes placed on both the scalp and the facial area. Pattern-evoked potentials (PERGs) were obtainable at the facial area in multiple sclerosis patients with optic neuritis, except in long-standing cases. However, a significant reduction of amplitude was found even in cases without optic neuritis. No correlation was found between visual acuity and amplitude or peak latency of PERGs in MS patients.

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Optic Neuropathy in Multiple Sclerosis

Cited by 52 publications

References 6 publications

Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patients

Retinal nerve fibre layer measurements and optic nerve head analysis in multiple sclerosis patients

Prognosis of optic neuritis with special reference to cerebrospinal fluid immunoglobuhs and measles virus antibodes

Facially distributed pattern-evoked potentials in multiple sclerosis

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