Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 optic pathway glioma task force.

Listernick, Robert; Louis, DN; Packer, RJ; Gutmann, DH

doi:10.1016/s0002-9394(14)70811-6

Cited by 66 publications

(106 citation statements)

References 7 publications

Supporting

Mentioning

100

Contrasting

Unclassified

Order By: Relevance

“…Patients with these tumors have a very high overall survival rate, 25 but they can cause some vision impairment in up to half of affected patients. 26 Up to 70% of OPGs are associated with NF1, 27 and NF1associated tumors are often diagnosed at an early age and rarely cause new vision loss after the age of 10 years. 28 In our cohort, 72% of astroglial tumor survivors with impaired vision or bilateral blindness were diagnosed before the age of 10 years, whereas 54% of those with unimpaired vision were.…”

Section: Discussionmentioning

confidence: 99%

Impact of vision loss among survivors of childhood central nervous system astroglial tumors

Blank

Fisher

et al. 2016

Cancer

View full text Add to dashboard Cite

Background The impact of impaired vision on cognitive and psychosocial outcomes among long-term survivors of childhood low-grade gliomas has not been investigated previously, but could inform therapeutic decision-making. Methods Data from the Childhood Cancer Survivor Study was used to investigate psychological (measures of cognitive/emotional function) and socioeconomic (education, income, employment, marital status, independent living) outcomes among astroglial tumors survivors grouped by: (a) vision without impairment, (b) vision with impairment including unilateral blindness, visual field deficits or amblyopia, or (c) bilateral blindness. The effect of vision status on outcomes was examined using multivariable logistic regression, adjusting for age, gender, cranial radiation therapy and medical comorbidities. Results Among 1,233 survivors of childhood astroglial tumor ≥ 5 years post-diagnosis, 277 (22.5%) had visual impairment. In multivariable analysis, survivors with bilateral blindness were more likely to be unmarried (adjusted odds ratio [95% confidence interval]: 4.7 [1.5, 15.0]), live with a caregiver (3.1 [1.3, 7.5]), and be unemployed (2.2 [1.1, 4.5]) compared to those without visual impairment. Bilateral blindness had no measureable effect on cognitive or emotional outcomes, and vision with impairment was not significantly associated with any psychological or socio-economic outcomes. Conclusions Adult survivors of childhood astroglial tumors with bilateral blindness are more likely to live unmarried and dependently and be unemployed. Survivors with visual impairment but some remaining vision did not differ significantly with regard to psychological function and socioeconomic status from those without visual impairment.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of vision loss among survivors of childhood central nervous system astroglial tumors

Blank

Fisher

et al. 2016

Cancer

View full text Add to dashboard Cite

show abstract

“…Previous studies have shown that if all children with NF1 underwent screening neuroimaging at the time of diagnosis, OPG would be detected in 15% of children 3, 6. Recent studies using international clinical databases similarly have estimated the prevalence rate of OPG at between 5 and 25% 22–24…”

Section: Clinical Characteristicsmentioning

confidence: 99%

“…In 1997, based on a task force composed of basic scientists and clinical researchers, guidelines for the management and diagnosis of NF1‐associated OPG were proposed 6. Since that time, there have been significant advances in both basic science and clinical research on these tumors, which has prompted us to reexamine those original recommendations.…”

mentioning

confidence: 99%

Optic pathway gliomas in neurofibromatosis‐1: Controversies and recommendations

Listernick

Ferner

Liu

et al. 2007

Annals of Neurology

522

423

View full text Add to dashboard Cite

Optic pathway glioma (OPG), seen in 15% to 20% of individuals with neurofibromatosis type 1 (NF1), account for significant morbidity in young children with NF1. Overwhelmingly a tumor of children younger than 7 years, OPG may present in individuals with NF1 at any age. Although many OPG may remain indolent and never cause signs or symptoms, others lead to vision loss, proptosis, or precocious puberty. Because the natural history and treatment of NF1-associated OPG is different from that of sporadic OPG in individuals without NF1, a task force composed of basic scientists and clinical researchers was assembled in 1997 to propose a set of guidelines for the diagnosis and management of NF1-associated OPG. This new review highlights advances in our understanding of the pathophysiology and clinical behavior of these tumors made over the last 10 years. Controversies in both the diagnosis and management of these tumors are examined. Finally, specific evidence-based recommendations are proposed for clinicians caring for children with NF1.

show abstract

“…On the other hand, a subset of NF-1 patients develops a more profuse neurofibroma tumour, plexiform neurofibroma, that can undergo transformation into highly metastatic cancer (malignant peripheral nerve sheath tumour) (51). The second most common tumour type in NF-1 patients is the optic glioma, which is a brain tumour composed of neoplastic astrocytes that may lead to blindness and endocrine abnormalities (54). Finally, young individuals with NF-1 infrequently develop myeloid leukaemia and myelodysplastic syndrome (55).…”

Section: Function Of the Nf-1 Genementioning

confidence: 99%

Fishing for new genes in skin biology: impact of cytogenetics on gene discovery

et al. 2004

View full text Add to dashboard Cite

Research into the field of skin biology has grown exponentially over the past two decades. Even though the fundamental molecular pathways are still not fully understood, there have been significant advances in our understanding of the underlying mechanisms involved in the pathogenesis of genodermatosis. The cloning of many candidate genes involved in the etiology of skin diseases has been facilitated by initial cytogenetic evidence. This review will synthesize recent findings that led to the discovery of candidate genes for anhidrotic ectodermal dysplasia, Williams-Beuren syndrome, neurofibromatosis-I and tricho-rhino-phalangeal syndrome.

show abstract

Optic pathway gliomas in children with neurofibromatosis 1: consensus statement from the NF1 optic pathway glioma task force.

Cited by 66 publications

References 7 publications

Impact of vision loss among survivors of childhood central nervous system astroglial tumors

Impact of vision loss among survivors of childhood central nervous system astroglial tumors

Optic pathway gliomas in neurofibromatosis‐1: Controversies and recommendations

Fishing for new genes in skin biology: impact of cytogenetics on gene discovery

Contact Info

Product

Resources

About