Optic radiations are thinner and show signs of iron deposition in patients with long-standing remitting-relapsing multiple sclerosis: an enhanced T2*-weighted angiography imaging study

Abstract

ObjectiveThis study aimed to investigate iron deposition and thickness and signal changes in optic radiation (OR) by enhanced T2*-weighted angiography imaging (ESWAN) in patients with relapsing-remitting multiple sclerosis (RRMS) with unilateral and bilateral lesions or no lesions.MethodsFifty-one RRMS patients (42 patients with a disease duration [DD] ≥ 2 years [group Mor], nine patients with a DD < 2 years [group Les]) and 51 healthy controls (group Con) underwent conventional magnetic resonance imaging (MRI) and ESWAN at 3.0 T. The mean phase value (MPV) of the OR was measured on the phase image, and thickness and signal changes of the OR were observed on the magnitude image.ResultsThe average MPVs for the OR were 1,981.55 ± 7.75 in group Mor, 1,998.45 ± 2.01 in group Les, and 2,000.48 ± 5.53 in group Con. In group Mor, 28 patients with bilateral OR lesions showed bilateral OR thinning with a heterogeneous signal, and 14 patients with unilateral OR lesions showed ipsilateral OR thinning with a heterogeneous signal. In the remaining nine patients without OR lesions and in group Con, the bilateral OR had a normal appearance. In the patients, a negative correlation was found between DD and OR thickness and a positive correlation was found between MPV and OR thickness.ConclusionsWe confirmed iron deposition in the OR in the RRMS patients, and the OR thickness was lower in the patients than in the controls.Key Points • Enhanced T 2 * -weighted magnetic resonance angiography (ESWAN) provides new insights into multiple sclerosis (MS). • Focal destruction of the optic radiation (OR) is detectable by ESWAN. • Iron deposition in OR can be measured on ESWAN phase image in MS patients. • OR thickness was lower in the patients than in the controls. • Iron deposition and thickness changes of the OR are associated with disease duration. Electronic supplementary materialThe online version of this article (10.1007/s00330-018-5461-8) contains supplementary material, which is available to authorized users.

3.0 T multi-parametric MRI reveals metabolic and microstructural abnormalities in the posterior visual pathways in patients with thyroid eye disease

“…DKI has been suggested to be sensitive for detecting alterations in diffusion, and our results differed from previous DTI studies in TED patients, which may be due to the methodological differences between DTI and DKI acquisition, processing parameters and the influence of the partial-volume effects ( Falangola et al, 2013 ). In contrast to previous findings, here changes in intraorbital optic nerve fibers were only found in Ka in the active group, while FA and MD showed only a slight and insignificant decreasing trend, most likely due to the intersection of axons in the optic chiasm ( Zeng et al, 2018 ) and the movement of the intraorbital optic nerves with eyeball movements ( Staempfli et al, 2007 ; Engelhorn et al, 2012 ).…”

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“…Recently, enhanced T 2 *-weighted angiography demonstrated significant advantages over susceptibility-weighted imaging, including higher SNR and reduced chemical shift artifact. This technique can be applied to better visualize iron decomposition and thickness changes within the optic radiations in multiple sclerosis 87 (Fig. 6a-c).…”