Optic replacement in a novel modular intraocular lens system

Abstract

Replacement of the Harmoni optic was found to be safe and efficient compared with the control IOL, as manipulation of the capsular bag to remove haptic components is not necessary with the modular design. The base component of the modular system remained stable and centred throughout the study.

Long‐term uveal and capsular biocompatibility of a novel modular intraocular lens system

“…found optic exchange in the ClarVista Harmoni ® Modular system to be easier than traditional IOL exchange with the control Alcon AcrySof SA60AT in the rabbit model at two and six weeks postoperatively (Guan et al. ). More manipulation of the capsular bag with subsequent increased stress on the zonules was required to disengage the haptics of the control lens as compared to the test lens, especially at the postoperative Week 6 exchange procedure given the accelerated proliferative capacity of rabbits (six weeks in the rabbit model correspond to roughly two years in humans) (Guan et al.…”

“…More manipulation of the capsular bag with subsequent increased stress on the zonules was required to disengage the haptics of the control lens as compared to the test lens, especially at the postoperative Week 6 exchange procedure given the accelerated proliferative capacity of rabbits (six weeks in the rabbit model correspond to roughly two years in humans) (Guan et al. ). This finding is particularly relevant to paediatric cataract surgery as multiple IOL exchanges are often required many years after the original procedure due to unpredictable degrees of myopic shift (Kraus et al.…”

“…; Guan et al. ). Using aseptic technique and a surgical microscope, a fornix‐based conjunctival flap was fashioned.…”

“…; Guan et al. ). Briefly, the extent and severity of ACO and PCO were scored as follows: ACO was scored from 0 to 4, at the area of anterior capsule contacting the anterior optic surface. Central PCO (related to the central 3 mm behind the optic) was scored from 0 to 4. Peripheral PCO (related to the peripheral area behind optic) was scored from 0 to 4. Soemmering's ring formation (related to proliferative material within the equatorial region of the capsular bag, outside of the optic) had a score of intensity from 0 to 4, and a score of area, related to the number of quadrants involving the highest intensity. …”

“…; Guan et al. ). In this study, we evaluate the long‐term stability and biocompatibility of the system, through a rabbit implantation protocol defined by the International Organization for Standardization (ISO) 11979‐5, Annex G:2006(E).…”