1999
DOI: 10.1007/s004150050381
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Optic-spinal form of multiple sclerosis and anti-thyroid autoantibodies

Abstract: The optic-spinal form of multiple sclerosis (OSMS), characterized by recurrent involvement of optic nerve and spinal cord with rare brain magnetic resonance imaging lesions, is relatively common among Asians. While individual cases of OSMS with anti-thyroid autoantibodies (ATABs) have been reported, the frequency of ATAbs in OSMS and classical multiple sclerosis has not been studied. We studied serum ATAbs and anti-nuclear antibodies (ANA) in 46 Japanese patients with multiple sclerosis: 14 with OSMS, and 32 w… Show more

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Cited by 23 publications
(13 citation statements)
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“…It is thought that this MS variant could represent a pathogenetic link between antithyroid autoimmunity and a subgroup of optic-spinal MS in Japanese individuals that is not related to HTLV-1 disease. 105 Rarely, optic nerve inflammation can be part of a paraneoplastic syndrome. Optic neuritis has been documented in cases involving bronchial carcinoma, oat cell carcinoma, and lymphoma.…”
Section: Clinical Presentation Of Optic Neuritismentioning
confidence: 99%
“…It is thought that this MS variant could represent a pathogenetic link between antithyroid autoimmunity and a subgroup of optic-spinal MS in Japanese individuals that is not related to HTLV-1 disease. 105 Rarely, optic nerve inflammation can be part of a paraneoplastic syndrome. Optic neuritis has been documented in cases involving bronchial carcinoma, oat cell carcinoma, and lymphoma.…”
Section: Clinical Presentation Of Optic Neuritismentioning
confidence: 99%
“…Her antithyroid peroxidase antibody was 99.0 IU/mL (0-30), her thyroid stimulatory hormone receptor antibody was 10.8 (0-9), her free T3 was 3.74 pmol/L (3.95-6.8), her free T4 was 17.98 pmol/L (12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22), and her thyroid stimulatory hormone was 1.14 mIU/mL (0.27-4.2). Her symptoms improved after 7 days of pulse steroid therapy.…”
Section: White Matter Alteration In a Patient With Graves' Diseasementioning
confidence: 99%
“…Hashimoto's thyroiditis is well known to coexist with other autoimmune diseases, including MS [9,10], but no study has reported the coincidence of MS and autoimmune thyroiditis. However, Sakuma et al [1] found one of 32 MS patients having positive anti-microsomal antibodies, and Kiessling and Pflughaupt [11] reported positive anti-microsomal antibodies in 13.5% of 110 MS patients examined [11].…”
mentioning
confidence: 94%
“…Sirs: I read with great interest the communication of Sakuma et al [1] concerning the optic-spinal form of multiple sclerosis (OSMS) and antithyroid autoantibodies [1]. Of the five anti-thyroid antibody positive OSMS patients only one had a spinal lesion on magnetic resonance imaging; the others showed no lesions either in the brain or in the spinal cord.…”
mentioning
confidence: 98%