This paper details the comprehensive activities conducted in a laboratory setting to assess the structural health monitoring (SHM) of prefabricated building envelopes. Integrating sensors into building components like curtain wall facades poses challenges but offers opportunities for monitoring structural health, requiring compliance with regulatory standards. The research investigates the possibility of defining a kit of conventional and multi-parameter sensors integrated within the building envelope to monitor its behavior during the performance test conducted. The kit of sensors also includes Fiber Optic Sensors for effectively monitoring building envelope behavior and structural integrity. In this context, the European project InComEss (H2020-GA862597) aims to define a stand-alone solution for SHM using Piezoelectric Energy Harvesting Systems (PE-EHS) for façade monitoring through FBG/FOS system. After analyzing the main façade structural stress, a series of FBGs, accelerometers, and force washers were integrated within a 1:1 scale façade prototype and tested in a laboratory following the test sequence parameters required by the curtain wall standard EN 13830. The data collected were analyzed with the aim of monitoring the façade behavior before and after the tests. The results show that the façade’s performance passed the assessing test criteria without reporting any damages. In addition, the outcomes demonstrated the effectiveness of the defined kit of multi-parameter sensors for the building envelope’s SHM.